1. Cross-Sectional Analysis of Clinical Trial Availability and North Carolina Neighborhood Social Vulnerability.
- Author
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Grant, Shakira J., Jansen, Matthew, Tzy-Mey Kuo, Rubinstein, Samuel M., Wildes, Tanya M., Tuchman, Sascha A., Muss, Hyman B., Lichtman, Eben I., and Charlot, Marjory
- Subjects
CANCER patient psychology ,STATISTICAL significance ,CLINICAL trials ,CONFIDENCE intervals ,PSYCHOLOGICAL vulnerability ,CROSS-sectional method ,SOCIAL factors ,HEALTH outcome assessment ,RACE ,POPULATION geography ,SOCIOECONOMIC factors ,SOCIAL classes ,DESCRIPTIVE statistics ,RESEARCH funding ,MULTIPLE myeloma ,SOCIODEMOGRAPHIC factors ,LOGISTIC regression analysis ,DATA analysis software ,ODDS ratio ,NEIGHBORHOOD characteristics ,ALGORITHMS ,POISSON distribution ,CLINICAL trial registries - Abstract
PURPOSE Residents of communities facing social vulnerability (eg, poverty) have limited access to clinical trials, leaving them susceptible to experiencing poor health outcomes. We examined the association between North Carolina county-level social vulnerability and available multiple myeloma (MM) trials. METHODS Using a novel data linkage between ClinicalTrials.gov, the 2019 American Community Survey, and the Centers for Disease Control and Prevention's Social Vulnerability Index, we investigated at the county level (1) availability of MM trial sites and (2) the relationship between Social Vulnerability Index and MM trial site availability using logistic regression. RESULTS Between 2002 and 2021, 229 trials were registered across 462 nonunique trial sites in 34 counties. Nearly 50% of trial sites were in academic medical centers, 80% (n = 372) of all trials were industry-sponsored, 60% (n=274) were early-phase, and 50% (n5232) were for patients with relapsed or refractory MM. Counties with low as opposed to high poverty rates had six times greater odds of having ≥1 MMtrial sites (odds ratio [OR], 5.60; 95% CI, 1.85 to 19.64; P = .004). Counties with the lowest percentage of Black Indigenous Persons of Color and non-native English speakers had 77% lower odds (OR, 0.23; 95% CI, 0.07 to 0.69; P = .011) of having ≥ 1 trial sites. The effect remained significant after accounting for the presence of five academic medical centers (n = 95; OR, 0.18; 95% CI, 0.05 to 0.6; P = .008) and adjustment for metropolitan, suburban, or rural status (OR, 0.25; 95% CI, 0.07 to 0.81; P = .025). CONCLUSION Counties with the lowest poverty rates had more MM trial sites, whereas those with the lowest percentage of Black Indigenous Persons of Color populations had fewer MM trial sites. Multilevel efforts are needed to improve the availability and access to trials for socially vulnerable populations. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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