1. Randomized Clinical Trial of Telephone-Administered Cognitive-Behavioral Therapy to Reduce Post-Traumatic Stress Disorder and Distress Symptoms After Hematopoietic Stem-Cell Transplantation
- Author
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Jane Austin, Jack E. Burkhalter, Paul B. Greene, Anna Rusiewicz, Gary Winkel, Esperanza B. Papadopoulos, Craig H. Moskowitz, Karen Hurley, Scott D. Rowley, Luis Isola, Yeraz Markarian Meschian, Katherine N. DuHamel, Larissa E. Labay, Christine Rini, Andreas R. Bollinger, William H. Redd, Catalina Lawsin, Catherine E. Mosher, Celia Grosskreutz, and Eileen Scigliano
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,medicine.medical_treatment ,law.invention ,Stress Disorders, Post-Traumatic ,Young Adult ,Randomized controlled trial ,law ,Original Reports ,medicine ,Humans ,Single-Blind Method ,Psychiatry ,Aged ,Cognitive Behavioral Therapy ,business.industry ,Depression ,Traumatic stress ,Hematopoietic Stem Cell Transplantation ,Middle Aged ,medicine.disease ,Telephone ,Cognitive behavioral therapy ,Transplantation ,Clinical trial ,Distress ,Oncology ,Physical therapy ,Cognitive therapy ,Female ,business ,Anxiety disorder - Abstract
Purpose A significant number of survivors of hematopoietic stem-cell transplantation (HSCT) report enduring adverse effects of treatment, including illness-related post-traumatic stress disorder (PTSD) symptoms and general distress. We report results of a randomized clinical trial that tested the effects of a 10-session, telephone-administered cognitive-behavioral therapy (CBT) intervention on PTSD, depression, and distress symptoms. Methods Survivors who had undergone HSCT 1 to 3 years earlier (N = 408) were assessed for study eligibility. Those who met study eligibility criteria (n = 89) completed a baseline assessment that included a clinical interview and self-report measures of PTSD symptoms (the primary outcome) and depression and general distress (the secondary outcomes). Next, they were randomly assigned to CBT or an assessment-only condition. Survivors in the CBT group completed 10 individual telephone-based CBT sessions (T-CBT) that included strategies to reduce PTSD symptoms, depression, and general distress. Follow-up assessments occurred at 6, 9, and 12 months after the baseline assessment. Results Linear mixed-model analyses revealed that, compared with HSCT survivors in the assessment-only condition, survivors who completed T-CBT reported fewer illness-related PTSD symptoms, including less avoidance (P < .001) and fewer intrusive thoughts (P < .05) as well as less general distress and fewer depressive symptoms (P < .05) even after controlling for potential demographic and medical covariates. These results were consistent across the three follow-up assessments. Conclusion A brief, telephone-administered CBT intervention developed for HSCT survivors is an efficacious treatment for reducing illness-related PTSD symptoms and general distress.
- Published
- 2010