1. Novel terpenoid-type quinones isolated from Pycnanthus angolensis of potential utility in the treatment of type 2 diabetes.
- Author
-
Luo J, Cheung J, Yevich EM, Clark JP, Tsai J, Lapresca P, Ubillas RP, Fort DM, Carlson TJ, Hector RF, King SR, Mendez CD, Jolad SD, and Reaven GM
- Subjects
- Adipocytes drug effects, Adipocytes metabolism, Animals, Blood Glucose drug effects, Cells, Cultured, Diabetes Mellitus, Experimental blood, Diabetes Mellitus, Experimental drug therapy, Diabetes Mellitus, Type 2 blood, Disease Models, Animal, Eating drug effects, Insulin blood, Male, Mice, Mice, Inbred C57BL, Plants, Medicinal chemistry, Trees chemistry, Diabetes Mellitus, Type 2 drug therapy, Hypoglycemic Agents pharmacology, Naphthoquinones pharmacology, Plant Extracts pharmacology
- Abstract
Using an ethnomedical-based drug discovery program, two previously unknown compounds (SP-18904 and SP-18905) from Pycnanthus angolensis were isolated that lower glucose concentrations in mouse models of type 2 diabetes. SP-18904 and SP-18905 are terpenoid-type quinones that significantly lowered plasma glucose concentration (p <.05) when given orally to either ob/ob or db/db mice, both of which are hyperglycemic and hyperinsulinemic. The antihyperglycemic actions of SP-18904 and SP-18905 were associated with significant decreases in plasma insulin concentrations (p <.05), suggesting that both compounds lowered glucose by enhancing insulin-mediated glucose uptake. This was supported by the insulin suppression test in ob/ob mice. Studies in hyperglycemic, insulin-deficient mice and in vitro experiments on 3T3-L1 adipocytes further supported this conclusion. As such, these two terpenoid-type quinones represent a new class of compounds of potential use in the treatment of type 2 diabetes.
- Published
- 1999