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Your search keyword '"Wietgrefe, Stephen"' showing total 5 results
Start Over Author "Wietgrefe, Stephen" Publisher american society for microbiology
5 results on '"Wietgrefe, Stephen"'

1. Detecting Sources of Immune Activation and Viral Rebound in HIV Infection

Author

Wietgrefe, Stephen W., primary, Duan, Lijie, additional, Anderson, Jodi, additional, Marqués, Guillermo, additional, Sanders, Mark, additional, Cummins, Nathan W., additional, Badley, Andrew D., additional, Dobrowolski, Curtis, additional, Karn, Jonathan, additional, Pagliuzza, Amélie, additional, Chomont, Nicolas, additional, Sannier, Gérémy, additional, Dubé, Mathieu, additional, Kaufmann, Daniel E., additional, Zuck, Paul, additional, Wu, Guoxin, additional, Howell, Bonnie J., additional, Reilly, Cavan, additional, Herschhorn, Alon, additional, Schacker, Timothy W., additional, and Haase, Ashley T., additional

Published
2022
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2. Humanized Mouse Model of HIV-1 Latency with Enrichment of Latent Virus in PD-1 + and TIGIT + CD4 T Cells

Author

Llewellyn, George N., primary, Seclén, Eduardo, additional, Wietgrefe, Stephen, additional, Liu, Siyu, additional, Chateau, Morgan, additional, Pei, Hua, additional, Perkey, Katherine, additional, Marsden, Matthew D., additional, Hinkley, Sarah J., additional, Paschon, David E., additional, Holmes, Michael C., additional, Zack, Jerome A., additional, Louie, Stan G., additional, Haase, Ashley T., additional, and Cannon, Paula M., additional

Published
2019
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3. Brain Macrophages in Simian Immunodeficiency Virus-Infected, Antiretroviral-Suppressed Macaques: a Functional Latent Reservoir

Author

Avalos, Claudia R., primary, Abreu, Celina M., additional, Queen, Suzanne E., additional, Li, Ming, additional, Price, Sarah, additional, Shirk, Erin N., additional, Engle, Elizabeth L., additional, Forsyth, Ellen, additional, Bullock, Brandon T., additional, Mac Gabhann, Feilim, additional, Wietgrefe, Stephen W., additional, Haase, Ashley T., additional, Zink, M. Christine, additional, Mankowski, Joseph L., additional, Clements, Janice E., additional, and Gama, Lucio, additional

Published
2017
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4. Propagation and Dissemination of Infection after Vaginal Transmission of Simian Immunodeficiency Virus

Author

Miller, Christopher J., primary, Li, Qingsheng, additional, Abel, Kristina, additional, Kim, Eun-Young, additional, Ma, Zhong-Min, additional, Wietgrefe, Stephen, additional, La Franco-Scheuch, Lisa, additional, Compton, Lara, additional, Duan, Lijie, additional, Shore, Marta Dykhuizen, additional, Zupancic, Mary, additional, Busch, Marc, additional, Carlis, John, additional, Wolinsky, Steven, additional, and Haase, Ashley T., additional

Published
2005
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5. A humanized mouse model of HIV-1 latency with enrichment of latent virus in PD-1+ and TIGIT+ CD4 T cells.

Author

Llewellyn, George N., Seclèn, Eduardo, Wietgrefe, Stephen, Siyu Liu, Chateau, Morgan, Hua Pei, Perkey, Katherine, Marsden, Matthew D., Hinkley, Sarah J., Paschon, David E., Holmes, Michael C., Zack, Jerome A., Louie, Stan G., Haase, Ashley T., and Cannon, Paula M.

Subjects
*T cells, *COMBINATION drug therapy, *MICE, *LYMPHOID tissue, *HUMAN T cells
Abstract

Combination anti-retroviral drug therapy (ART) potently suppresses HIV-1 replication but does not result in virus eradication or a cure. A major contributing factor is the long-term persistence of a reservoir of latently infected cells. To study this reservoir, we established a humanized mouse model of HIV-1 infection and ART suppression based on an oral ART regimen. Similar to humans, HIV-1 levels in the blood of ART-treated animals were frequently suppressed below the limits of detection. However, the limited timeframe of the mouse model and the small volume of available samples makes it a challenging model with which to achieve full viral suppression and to investigate the latent reservoir. We therefore used an ex vivo latency reactivation assay that allows a semiquantitative measure of the latent reservoir that establishes in individual animals, regardless of whether they are treated with ART. Using this assay, we found that latently infected human CD4 T cells can be readily detected in mouse lymphoid tissues and that latent HIV-1 was enriched in populations expressing markers of T cell exhaustion, PD-1 and TIGIT. In addition, we were able to use the ex vivo latency reactivation assay to demonstrate that HIV-specific TALENs can reduce the fraction of reactivatable virus in the latently infected cell population that establishes in vivo, supporting the use of targeted nuclease-based approaches for an HIV-1 cure. [ABSTRACT FROM AUTHOR]

Published
2019
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