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1. Whole-Genome Analysis Surveillance of Influenza A Virus Resistance to Polymerase Complex Inhibitors in Eastern Spain from 2016 to 2019.

Author

Mengual-Chuliá B, Alonso-Cordero A, Cano L, Mosquera MDM, de Molina P, Vendrell R, Reyes-Prieto M, Jané M, Torner N, Martínez AI, Vila J, Díez-Domingo J, Marcos MÁ, and López-Labrador FX

Subjects
Antiviral Agents pharmacology, Antiviral Agents therapeutic use, Drug Resistance, Viral genetics, Humans, Spain epidemiology, Influenza A virus genetics, Influenza, Human drug therapy, Influenza, Human epidemiology
Abstract

Molecular surveillance by whole-genome sequencing was used to monitor the susceptibility of circulating influenza A viruses to three polymerase complex inhibitors. A total of 12 resistance substitutions were found among 285 genomes analyzed, but none were associated with high levels of resistance. Natural resistance to these influenza A antivirals is currently uncommon., (Copyright © 2021 American Society for Microbiology.)

Published
2021
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