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Your search keyword '"Uraki, Ryuta"' showing total 5 results
Start Over Author "Uraki, Ryuta" Publisher american society for microbiology
5 results on '"Uraki, Ryuta"'

1. Aedes aegypti NeSt1 Protein Enhances Zika Virus Pathogenesis by Activating Neutrophils

Author

Hastings, Andrew K., primary, Uraki, Ryuta, additional, Gaitsch, Hallie, additional, Dhaliwal, Khushwant, additional, Stanley, Sydney, additional, Sproch, Hannah, additional, Williamson, Eric, additional, MacNeil, Tyler, additional, Marin-Lopez, Alejandro, additional, Hwang, Jesse, additional, Wang, Yuchen, additional, Grover, Jonathan R., additional, and Fikrig, Erol, additional

Published
2019
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2. Disease Severity Is Associated with Differential Gene Expression at the Early and Late Phases of Infection in Nonhuman Primates Infected with Different H5N1 Highly Pathogenic Avian Influenza Viruses

Author

Muramoto, Yukiko, primary, Shoemaker, Jason E., additional, Le, Mai Quynh, additional, Itoh, Yasushi, additional, Tamura, Daisuke, additional, Sakai-Tagawa, Yuko, additional, Imai, Hirotaka, additional, Uraki, Ryuta, additional, Takano, Ryo, additional, Kawakami, Eiryo, additional, Ito, Mutsumi, additional, Okamoto, Kiyoko, additional, Ishigaki, Hirohito, additional, Mimuro, Hitomi, additional, Sasakawa, Chihiro, additional, Matsuoka, Yukiko, additional, Noda, Takeshi, additional, Fukuyama, Satoshi, additional, Ogasawara, Kazumasa, additional, Kitano, Hiroaki, additional, and Kawaoka, Yoshihiro, additional

Published
2014
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5. Virulence determinants of pandemic A(H1N1)2009 influenza virus in a mouse model.

Author

Uraki R, Kiso M, Shinya K, Goto H, Takano R, Iwatsuki-Horimoto K, Takahashi K, Daniels RS, Hungnes O, Watanabe T, and Kawaoka Y

Subjects
Animals, Disease Models, Animal, Female, Humans, Influenza A Virus, H1N1 Subtype genetics, Influenza A Virus, H1N1 Subtype isolation & purification, Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections pathology, Orthomyxoviridae Infections virology, Reassortant Viruses genetics, Reassortant Viruses isolation & purification, Reassortant Viruses pathogenicity, Viral Proteins genetics, Virulence, Virulence Factors genetics, Influenza A Virus, H1N1 Subtype pathogenicity, Viral Proteins metabolism, Virulence Factors metabolism
Abstract

A novel swine-origin H1N1 influenza virus [A(H1N1)pdm09 virus] caused the 2009 influenza pandemic. Most patients exhibited mild symptoms similar to seasonal influenza, but some experienced severe clinical signs and, in the worst cases, died. Such differences in symptoms are generally associated with preexisting medical conditions, but recent reports indicate the possible involvement of viral factors in clinical severity. To better understand the mechanism of pathogenicity of the A(H1N1)pdm09 virus, here, we compared five viruses that are genetically similar but were isolated from patients with either severe or mild symptoms. In a mouse model, A/Norway/3487/2009 (Norway3487) virus exhibited greater pathogenicity than did A/Osaka/164/2009 (Osaka164) virus. By exploiting reassortant viruses between these two viruses, we found that viruses possessing the hemagglutinin (HA) gene of Norway3487 in the genetic background of Osaka164 were more pathogenic in mice than other reassortant viruses, indicating a role for HA in the high virulence of Norway3487 virus. Intriguingly, a virus possessing HA, NA, and NS derived from Norway3487 exhibited greater pathogenicity in mice in concert with PB2 and PB1 derived from Osaka164 than did the parental Norway3487 virus. These findings demonstrate that reassortment between A(H1N1)pdm09 viruses can lead to increased pathogenicity and highlight the need for continued surveillance of A(H1N1)pdm09 viruses.

Published
2013
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