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Your search keyword '"Thys, J. P."' showing total 7 results
Start Over Author "Thys, J. P." Publisher american society for microbiology
7 results on '"Thys, J. P."'

7. Penetration of meropenem in lung, bronchial mucosa, and pleural tissues.

Author

Byl B, Jacobs F, Roucloux I, de Franquen P, Cappello M, and Thys JP

Subjects
Adult, Aged, Half-Life, Humans, Meropenem, Middle Aged, Mucous Membrane metabolism, Tissue Distribution, Bronchi metabolism, Lung metabolism, Pleura metabolism, Thienamycins pharmacokinetics
Abstract

Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.

Published
1999
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