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Your search keyword '"Rodriguez-Bano J."' showing total 3 results
Start Over Author "Rodriguez-Bano J." Publisher american society for microbiology
3 results on '"Rodriguez-Bano J."'

1. Propensity Score and Desirability of Outcome Ranking Analysis of Ertapenem for Treatment of Nonsevere Bacteremic Urinary Tract Infections Due to Extended-Spectrum-Beta-Lactamase-Producing Enterobacterales in Kidney Transplant Recipients

Author

Gutierrez-Gutierrez, B., Perez-Nadales, E., Perez-Galera, S., Fernandez-Ruiz, M., Carratala, J., Oriol, I., Cordero, E., Lepe, J. A., Tan, B. H., Corbella, L., Paul, M., Natera, A. M., David, M. D., Montejo, M., Iyer, R. N., Pierrotti, L. C., Merino, E., Steinke, S. M., Rana, M. M., Munoz, P., Mularoni, A., van Delden, C., Grossi, P. A., Seminari, E. M., Gunseren, F., Lease, E. D., Roilides, E., Fortun, J., Arslan, H., Coussement, J., Tufan, Z. K., Pilmis, B., Rizzi, M., Loeches, B., Eriksson, B. M., Abdala, E., Soldani, F., Lowman, W., Clemente, W. T., Bodro, M., Farinas, M. C., Kazak, E., Martinez-Martinez, L., Aguado, J. M., Torre-Cisneros, J., Pascual, A., Rodriguez-Bano, J., Sabe, N., Camoez, M., Martin-Gandul, C., Bernal, G., Kee, T. Y. S., Lopez-Medrano, F., Juan, R. S., Koppel, F., Bar-Sinai, N., Caston, J. J., Cano, A., Gracia-Ahufinger, I., Rodriguez, R., Lopez-Soria, L., Azurmendi, M., Pinheiro, M., Freire, M., Banks, I., Lopes, F., David-Neto, E., Balibrea, N., Franco, A., Avery, R., Ostrander, D., Minero, M. V., Carrillo, C. S., Rodriguez-Ferrero, M. L., Monaco, F., Campanella, M., Mueller, N. J., Manuel, O., Khanna, N., Rovelli, C., Balsamo, M. L., Colombo, A., Leoni, C., Pyrpasopoulou, A., Mouloudi, E., Iosifidis, E., Martin-Davila, P., Gioia, F., Escudero, R., Demirkaya, M. H., Dewispelaere, L., Kalem, A. K., Hasanoglu, I., Guner, R., Lortholary, O., Scemla, A., Calvi, E. G., Gervasi, E., Binda, F., Oliva, M. L., Dimopoulos, N., Magalhaes, M. R., Song, A. T. W., D'Albuquerque, L. A. C., Chiesi, S., Salerno, N. D., Mourao, P. H. O., Moreno, A., Linares, L., Almela, M., Rico, C. G., Rodrigo, E., Martinez, M. F., Falcone, M., Tumbarello, M., Strabelli, T. M. V., Instituto de Salud Carlos III, Ministerio de Ciencia, Innovación y Universidades (España), Red Española de Investigación en Patología Infecciosa, European Commission, Sociedad Andaluza de Trasplante de Órganos y Tejidos, and Ministerio de Ciencia e Innovación (España)

Subjects
Ertapenem, medicine.medical_specialty, Urinary system, UTI, Bacteremia, Bloodstream infection, BSI, Logistic regression, Extended-spectrum-b-lactamase-producing Enterobacterales, Meropenem, beta-Lactamases, Cohort Studies, chemistry.chemical_compound, Internal medicine, polycyclic compounds, medicine, Humans, Pharmacology (medical), Propensity Score, Kidney transplant, Retrospective Studies, Pharmacology, Urinary tract infection, business.industry, ESBL-E, Anti-Bacterial Agents, Kidney Transplantation, Urinary Tract Infections, bacterial infections and mycoses, medicine.disease, Infectious Diseases, chemistry, Propensity score matching, Cohort, business, medicine.drug, Cohort study
Abstract

REIPI/ESGICH/ESGBIS/INCREMENT-SOT Group., There are scarce data on the efficacy of ertapenem in the treatment of bacteremia due to extended-spectrum-beta-lactamase (ESBL)-producing Enterobacterales (ESBL-E) in kidney transplant (KT) recipients. We evaluated the association between treatment with ertapenem or meropenem and clinical cure in KT recipients with nonsevere bacteremic urinary tract infections (B-UTI) caused by ESBL-E. We performed a registered, retrospective, international (29 centers in 14 countries) cohort study (INCREMENT-SOT, NCT02852902). The association between targeted therapy with ertapenem versus meropenem and clinical cure at day 14 (the principal outcome) was studied by logistic regression. Propensity score matching and desirability of outcome ranking (DOOR) analyses were also performed. A total of 201 patients were included; only 1 patient (treated with meropenem) in the cohort died. Clinical cure at day 14 was reached in 45/100 (45%) and 51/101 (50.5%) of patients treated with ertapenem and meropenem, respectively (adjusted OR 1.29; 95% CI 0.51 to 3.22; P = 0.76); the propensity score-matched cohort included 55 pairs (adjusted OR for clinical cure at day 14, 1.18; 95% CI 0.43 to 3.29; P = 0.74). In this cohort, the proportion of cases treated with ertapenem with better DOOR than with meropenem was 49.7% (95% CI, 40.4 to 59.1%) when hospital stay was considered. It ranged from 59 to 67% in different scenarios of a modified (weights-based) DOOR sensitivity analysis when potential ecological advantage or cost was considered in addition to outcome. In conclusion, targeted therapy with ertapenem appears as effective as meropenem to treat nonsevere B-UTI due to ESBL-E in KT recipients and may have some advantages., This work was supported by Plan Nacional de I+D+i 2013‐2016 and Instituto de Salud Carlos III (ISCIII), Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001, RD16/0016/0002, RD16/0016/0008; RD16/0016/00010) and was cofinanced by the European Development Regional Fund “A way to achieve Europe,” Operative program Intelligent Growth 2014‐2020; ESCMID Study Group for Infections in Compromised Hosts (ESGICH grant to J.M.A.); Sociedad Andaluza de Trasplante de Órgano Sólido (SATOT grant to L.M.-M.); ESCMID Study Group for Bloodstream Infections and Sepsis (ESGBIS); and ESCMID Study Group for Antimicrobial Resistance Surveillance (ESGARS). B.G.-G. (PI 18/01849) and E.P.-N. (PI 16/01631) have received research funds from the Spanish Ministry of Science and Innovation, ISCIII; M.F.-R. holds a research contract “Miguel Servet” (CP 18/00073) from the Spanish Ministry of Science and Innovation, ISCIII.

Published
2021

3. Genomic Evolution of Two Acinetobacter baumannii Clinical Strains from ST-2 Clones Isolated in 2000 and 2010 (ST-2_clon_2000 and ST-2_clon_2010)

Author

Lopez, M., Rueda, A., Florido, J. P., Blasco, L., Gato, E., Fernandez-Garcia, L., Martinez-Martinez, L., Fernandez-Cuenca, F., Pachon, J., Cisneros, J. M., Garnacho-Montero, J., Vila, J., Rodriguez-Bano, J., Pascual, A., Bou, G., Tomas, M., Spanish Soc Clinical Microbiology, Spanish Network Res Infectious Dis, [Lopez, M.] Complejo Hosp Univ, Dept Microbiol, INIBIC, La Coruna, Spain, [Blasco, L.] Complejo Hosp Univ, Dept Microbiol, INIBIC, La Coruna, Spain, [Gato, E.] Complejo Hosp Univ, Dept Microbiol, INIBIC, La Coruna, Spain, [Fernandez-Garcia, L.] Complejo Hosp Univ, Dept Microbiol, INIBIC, La Coruna, Spain, [Tomas, M.] Complejo Hosp Univ, Dept Microbiol, INIBIC, La Coruna, Spain, [Rueda, A.] GBPA, Bioinformat, Seville, Spain, [Florido, J. P.] GBPA, Bioinformat, Seville, Spain, [Martinez-Martinez, L.] Hosp Univ Marques de Valdecilla IFIMAV, Dept Clin Microbiol, Santander, Spain, [Martinez-Martinez, L.] Univ Cantabria, Dept Mol Biol, Santander, Spain, [Fernandez-Cuenca, F.] Hosp Univ Virgen Macarena, Unidad Intercentros Enfermedades Infecciosas Micr, Seville, Spain, [Garnacho-Montero, J.] Hosp Univ Virgen Macarena, Unidad Intercentros Enfermedades Infecciosas Micr, Seville, Spain, [Rodriguez-Bano, J.] Hosp Univ Virgen Macarena, Unidad Intercentros Enfermedades Infecciosas Micr, Seville, Spain, [Pascual, A.] Hosp Univ Virgen Macarena, Unidad Intercentros Enfermedades Infecciosas Micr, Seville, Spain, [Pachon, J.] Univ Seville, CSIC, Univ Hosp Virgen del Rocio, Inst Biomed Seville IBiS, Seville, Spain, [Cisneros, J. M.] Univ Seville, CSIC, Univ Hosp Virgen del Rocio, Inst Biomed Seville IBiS, Seville, Spain, [Garnacho-Montero, J.] Univ Barcelona, Hosp Clin, Dept Clin Microbiol, Barcelona Sch Med, Barcelona, Spain, [Vila, J.] Univ Barcelona, Hosp Clin, Dept Clin Microbiol, Barcelona Sch Med, Barcelona, Spain, [Garnacho-Montero, J.] Hosp Clin Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona, Spain, [Vila, J.] Hosp Clin Barcelona, Barcelona Ctr Int Hlth Res CRESIB, ISGlobal, Barcelona, Spain, [Lopez, M.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Gato, E.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Martinez-Martinez, L.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Fernandez-Cuenca, F.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Pachon, J.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Cisneros, J. M.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Vila, J.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Rodriguez-Bano, J.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Pascual, A.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Bou, G.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, [Tomas, M.] Spanish Network Res Infect Dis REIPI RD12 0015, Seville, Spain, State Plan for R+D+I 2013-2016 (National Plan for Scientific Research, Technological Development and Innovation 2008-2011), ISCIII-Deputy General Directorate of Evaluation and Promotion of Research-European Regional Development Fund 'A Way of Making Europe', Instituto de Salud Carlos III FEDER, Spanish Network for Research in Infectious Diseases, Miguel Servet Research Programme (C.H.U.A. Coruna), Miguel Servet Research Programme (ISCIII), and Universitat de Barcelona

Subjects
0301 basic medicine, Transposable element, Gram-negative bacteria, biology, Bacteris gramnegatius, 030106 microbiology, Genomics, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, bacterial infections and mycoses, Genome, Microbiology, Acinetobacter baumannii, 03 medical and health sciences, Genòmica, 030104 developmental biology, Plasmid, GenBank, Genetics, bacteria, Prokaryotes, Mobile genetic elements, Molecular Biology
Abstract

Acinetobacter baumannii is a successful nosocomial pathogen due to its ability to persist in hospital environments by acquiring mobile elements such as transposons, plasmids, and phages. In this study, we compared two genomes of A. baumannii clinical strains isolated in 2000 (ST-2_clon_2000) and 2010 (ST-2_clon_2010) from GenBank project PRJNA308422.

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