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1. Lack of an effect of antibiotic treatment on prolonged detection of chlamydial DNA in murine genital tract infection.

Author

Reeves DM, Nagarajan U, O'Connell C, Andrews CW Jr, and Darville T

Subjects
Animals, Chlamydia Infections etiology, DNA, Fungal genetics, Female, Genital Diseases, Female drug therapy, Genital Diseases, Female pathology, Mice, Mice, Inbred BALB C, Nucleic Acid Amplification Techniques, Plasmids genetics, Polymerase Chain Reaction, Time Factors, Anti-Bacterial Agents pharmacology, Chlamydia Infections drug therapy, Chlamydia muridarum drug effects, DNA, Fungal analysis, Doxycycline pharmacology
Abstract

Mice treated with antibiotics early or late after active infection had resolved were examined for chlamydial DNA in endocervical swabs. The early eradication of infection limited oviduct pathology, despite the continued detection of chlamydial DNA by nested PCR. Late antibiotic treatment had no effect on the ability to detect DNA or oviduct pathology.

Published
2007
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