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Your search keyword '"Raviprakash, Kanakatte"' showing total 6 results
Start Over Author "Raviprakash, Kanakatte" Publisher american society for microbiology
6 results on '"Raviprakash, Kanakatte"'

4. A Heterologous DNA Prime-Venezuelan Equine Encephalitis Virus Replicon Particle Boost Dengue Vaccine Regimen Affords Complete Protection from Virus Challenge in Cynomolgus Macaques

Author

Chen, Lan, primary, Ewing, Dan, additional, Subramanian, Hemavathy, additional, Block, Karla, additional, Rayner, Jonathan, additional, Alterson, Kimberly D., additional, Sedegah, Martha, additional, Hayes, Curtis, additional, Porter, Kevin, additional, and Raviprakash, Kanakatte, additional

Published
2007
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6. A Heterologous DNA Prime-Venezuelan Equine Encephalitis Virus Replicon Particle Boost Dengue Vaccine Regimen Affords Complete Protection from Virus Challenge in Cynomolgus Macaques.

Author

Lan Chen, Ewing, Dan, Subramanian, Hemavathy, Block, Karla, Rayner, Jonathan, Alterson, Kimberly D., Sedegah, Martha, Hayes, Curtis, Porter, Kevin, and Raviprakash, Kanakatte

Subjects
*EQUINE encephalomyelitis, *VIRAL disease prevention, *DENGUE viruses, *DNA vaccines, *VIRAL vaccines, *LABORATORY monkeys
Abstract

A candidate vaccine (D1ME-VRP) expressing dengue virus type 1 premembrane and envelope proteins in a Venezuelan equine encephalitis (VEE) virus replicon particle (VRP) system was constructed and tested in conjunction with a plasmid DNA vaccine (D1ME-DNA) expressing identical dengue virus sequences. Cynomolgus macaques were vaccinated with three doses of DNA (DDD), three doses of VRP (VVV group), or a heterologous DNA prime-VRP boost regimen (DDV) using two doses of DNA vaccine and a third dose of VRP vaccine. Four weeks after the final immunization, the DDV group produced the highest dengue virus type 1-specific immunoglobulin G antibody responses and virus-neutralizing antibody titers. Moderate T-cell responses were demonstrated only in DDD- and DDV-vaccinated animals. When vaccinated animals were challenged with live virus, all vaccination regimens showed significant protection from viremia. DDV-immunized animals were completely protected from viremia (mean time of viremia = 0 days), whereas DDD- and VVV-vaccinated animals had mean times of viremia of 0.66 and 0.75 day, respectively, compared to 6.33 days for the control group of animals. [ABSTRACT FROM AUTHOR]

Published
2007
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