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Start Over Author "Ottenhoff, Tom" Publisher american society for microbiology
39 results on '"Ottenhoff, Tom"'

1. BCG Vaccination of Health Care Workers Does Not Reduce SARS-CoV-2 Infections nor Infection Severity or Duration: a Randomized Placebo-Controlled Trial

Author

Claus, Juana, primary, ten Doesschate, Thijs, additional, Gumbs, Cheyenne, additional, van Werkhoven, Cornelis H., additional, van der Vaart, Thomas W., additional, Janssen, Axel B., additional, Smits, Gaby, additional, van Binnendijk, Rob, additional, van der Klis, Fiona, additional, van Baarle, Debbie, additional, Paganelli, Fernanda L., additional, Leavis, Helen, additional, Verhagen, Lilly M., additional, Joosten, Simone A., additional, Bonten, Marc J. M., additional, Netea, Mihai G., additional, van de Wijgert, Janneke H. H. M., additional, Boersma, Wim G., additional, Bulut, Özlem, additional, van Crevel, Reinout, additional, Debisarun, Priya A., additional, Hoogerwerf, Jacobien, additional, de Jonge, Marien, additional, Kerckhoffs, Angele P. M., additional, Knol, Edward, additional, Koopman, Jan Pieter R., additional, Kuiper, Vincent P., additional, Lalmohamed, Arief, additional, Moorlag, Simone J. C. F. M., additional, Nierkens, Stefan, additional, van Nieuwkoop, Cees, additional, 10 Oever, Jaap, additional, Ottenhoff, Tom H. M., additional, Paternotte, Nienke, additional, Rijnders, Bart J. A., additional, Roukens, Anna H. E., additional, Taks, Esther, additional, Top, Janetta, additional, Veerman, Karin M., additional, Voss, Andreas, additional, and Willems, Rob, additional

Published
2023
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2. Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis

Author

Boland, Ralf, primary, Heemskerk, Matthias T., additional, Forn-Cuní, Gabriel, additional, Korbee, Cornelis J., additional, Walburg, Kimberley V., additional, Esselink, Jeroen J., additional, Carvalho dos Santos, Carina, additional, de Waal, Amy M., additional, van der Hoeven, Daniel C. M., additional, van der Sar, Elisa, additional, de Ries, Alex S., additional, Xie, Jiajun, additional, Spaink, Herman P., additional, van der Vaart, Michiel, additional, Haks, Mariëlle C., additional, Meijer, Annemarie H., additional, and Ottenhoff, Tom H. M., additional

Published
2023
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6. Identification of Immunological Biomarkers Which May Differentiate Latent Tuberculosis from Exposure to Environmental Nontuberculous Mycobacteria in Children

Author

Hur, Yun-Gyoung, primary, Crampin, Amelia C., additional, Chisambo, Christina, additional, Kanyika, James, additional, Houben, Rein, additional, Ndhlovu, Richard, additional, Mzembe, Themba, additional, Lalor, Maeve K., additional, Saul, Jacky, additional, Branson, Keith, additional, Stanley, Carolynne, additional, Ngwira, Bagrey, additional, French, Neil, additional, Ottenhoff, Tom H., additional, Dockrell, Hazel M., additional, and Gorak-Stolinska, Patricia, additional

Published
2014
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7. Low Induction of Proinflammatory Cytokines Parallels Evolutionary Success of Modern Strains within the Mycobacterium tuberculosis Beijing Genotype

Author

van Laarhoven, Arjan, primary, Mandemakers, Jornt J., additional, Kleinnijenhuis, Johanneke, additional, Enaimi, Mimount, additional, Lachmandas, Ekta, additional, Joosten, Leo A. B., additional, Ottenhoff, Tom H. M., additional, Netea, Mihai G., additional, van Soolingen, Dick, additional, and van Crevel, Reinout, additional

Published
2013
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8. Analysis of Immune Responses against a Wide Range of Mycobacterium tuberculosis Antigens in Patients with Active Pulmonary Tuberculosis

Author

Kassa, Desta, primary, Ran, Leonie, additional, Geberemeskel, Wudneh, additional, Tebeje, Mekashaw, additional, Alemu, Amelewerk, additional, Selase, Alemayehu, additional, Tegbaru, Belete, additional, Franken, Kees L. M. C., additional, Friggen, Annemieke H., additional, van Meijgaarden, Krista E., additional, Ottenhoff, Tom H. M., additional, Wolday, Dawit, additional, Messele, Tsehaynesh, additional, and van Baarle, Debbie, additional

Published
2012
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9. Risk Factors Associated with Indeterminate Gamma Interferon Responses in the Assessment of Latent Tuberculosis Infection in a High-Incidence Environment

Author

Oni, Tolu, primary, Gideon, Hannah P., additional, Bangani, Nonzwakazi, additional, Tsekela, Relebohile, additional, Seldon, Ronnett, additional, Wood, Kathryn, additional, Wilkinson, Katalin A., additional, Goliath, Rene T., additional, Ottenhoff, Tom H. M., additional, and Wilkinson, Robert J., additional

Published
2012
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11. Identification of Human T-Cell Responses to Mycobacterium tuberculosis Resuscitation-Promoting Factors in Long-Term Latently Infected Individuals

Author

Commandeur, Susanna, primary, van Meijgaarden, Krista E., additional, Lin, May Young, additional, Franken, Kees L. M. C., additional, Friggen, Annemieke H., additional, Drijfhout, Jan Wouter, additional, Oftung, Fredrik, additional, Korsvold, Gro Ellen, additional, Geluk, Annemieke, additional, and Ottenhoff, Tom H. M., additional

Published
2011
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13. Cross-Reactive Immunity to Mycobacterium tuberculosis DosR Regulon-Encoded Antigens in Individuals Infected with Environmental, Nontuberculous Mycobacteria

Author

Lin, May Young, primary, Reddy, T. B. K., additional, Arend, Sandra M., additional, Friggen, Annemieke H., additional, Franken, Kees L. M. C., additional, van Meijgaarden, Krista E., additional, Verduyn, Marleen J. C., additional, Schoolnik, Gary K., additional, Klein, Michel R., additional, and Ottenhoff, Tom H. M., additional

Published
2009
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14. Immunogenicity of Novel DosR Regulon-Encoded Candidate Antigens of Mycobacterium tuberculosis in Three High-Burden Populations in Africa

Author

Black, Gillian F., primary, Thiel, Bonnie A., additional, Ota, Martin O., additional, Parida, Shreemanta K., additional, Adegbola, Richard, additional, Boom, W. Henry, additional, Dockrell, Hazel M., additional, Franken, Kees L. M. C., additional, Friggen, Annemiek H., additional, Hill, Philip C., additional, Klein, Michel R., additional, Lalor, Maeve K., additional, Mayanja, Harriet, additional, Schoolnik, Gary, additional, Stanley, Kim, additional, Weldingh, Karin, additional, Kaufmann, Stefan H. E., additional, Walzl, Gerhard, additional, and Ottenhoff, Tom H. M., additional

Published
2009
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19. Lack of Immune Responses to Mycobacterium tuberculosis DosR Regulon Proteins following Mycobacterium bovis BCG Vaccination

Author

Lin, May Young, primary, Geluk, Annemieke, additional, Smith, Steven G., additional, Stewart, Amanda L., additional, Friggen, Annemieke H., additional, Franken, Kees L. M. C., additional, Verduyn, Marleen J. C., additional, van Meijgaarden, Krista E., additional, Voskuil, Martin I., additional, Dockrell, Hazel M., additional, Huygen, Kris, additional, Ottenhoff, Tom H. M., additional, and Klein, Michèl R., additional

Published
2007
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21. Dynamic Changes in Pro- and Anti-Inflammatory Cytokine Profiles and Gamma Interferon Receptor Signaling Integrity Correlate with Tuberculosis Disease Activity and Response to Curative Treatment

Author

Sahiratmadja, Edhyana, primary, Alisjahbana, Bachti, additional, de Boer, Tjitske, additional, Adnan, Iskandar, additional, Maya, Anugrah, additional, Danusantoso, Halim, additional, Nelwan, Ronald H. H., additional, Marzuki, Sangkot, additional, van der Meer, Jos W. M., additional, van Crevel, Reinout, additional, van de Vosse, Esther, additional, and Ottenhoff, Tom H. M., additional

Published
2007
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24. Postgenomic Approach To Identify Novel Mycobacterium leprae Antigens with Potential To Improve Immunodiagnosis of Infection

Author

Geluk, Annemieke, primary, Klein, Michèl R., additional, Franken, Kees L. M. C., additional, van Meijgaarden, Krista E., additional, Wieles, Brigitte, additional, Pereira, Kelly Cristina, additional, Bührer-Sékula, Samira, additional, Klatser, Paul R., additional, Brennan, Patrick J., additional, Spencer, John S., additional, Williams, Diana L., additional, Pessolani, Maria C. V., additional, Sampaio, Elizabeth P., additional, and Ottenhoff, Tom H. M., additional

Published
2005
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25. ESAT-6/CFP-10 Fusion Protein and Peptides for Optimal Diagnosis of Mycobacterium tuberculosis Infection by Ex Vivo Enzyme-Linked Immunospot Assay in The Gambia

Author

Hill, Philip C., primary, Jackson-Sillah, Dolly, additional, Fox, Annette, additional, Franken, Kees L. M. C., additional, Lugos, Moses D., additional, Jeffries, David J., additional, Donkor, Simon A., additional, Hammond, Abdulrahman S., additional, Adegbola, Richard A., additional, Ottenhoff, Tom H. M., additional, Klein, Michel R., additional, and Brookes, Roger H., additional

Published
2005
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26. Epstein-Barr Virus gp42 Is Posttranslationally Modified To Produce Soluble gp42 That Mediates HLA Class II Immune Evasion

Author

Ressing, Maaike E., primary, van Leeuwen, Daphne, additional, Verreck, Frank A. W., additional, Keating, Sinéad, additional, Gomez, Raquel, additional, Franken, Kees L. M. C., additional, Ottenhoff, Tom H. M., additional, Spriggs, Melanie, additional, Schumacher, Ton N., additional, Hutt-Fletcher, Lindsey M., additional, Rowe, Martin, additional, and Wiertz, Emmanuel J. H. J., additional

Published
2005
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28. T-Cell Responses to the Mycobacterium tuberculosis- Specific Antigen ESAT-6 in Brazilian Tuberculosis Patients

Author

Cardoso, Fernando L. L., primary, Antas, Paulo R. Z., additional, Milagres, Alexandre S., additional, Geluk, Annemieke, additional, Franken, Kees L. M. C., additional, Oliveira, Eliane B., additional, Teixeira, Henrique C., additional, Nogueira, Susie A., additional, Sarno, Euzenir N., additional, Klatser, Paul, additional, Ottenhoff, Tom H. M., additional, and Sampaio, Elizabeth P., additional

Published
2002
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30. Identification and Characterization of the ESAT-6 Homologue ofMycobacterium lepraeand T-Cell Cross-Reactivity withMycobacterium tuberculosis

Author

Geluk, Annemieke, primary, van Meijgaarden, Krista E., additional, Franken, Kees L. M. C., additional, Subronto, Yanri W., additional, Wieles, Brigitte, additional, Arend, Sandra M., additional, Sampaio, Elizabeth P., additional, de Boer, Tjitske, additional, Faber, William R., additional, Naafs, Ben, additional, and Ottenhoff, Tom H. M., additional

Published
2002
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33. Presence of Human T-Cell Responses to theMycobacterium leprae45-Kilodalton Antigen Reflects Infection with or Exposure toM. leprae

Author

Macfarlane, Anne, primary, Mondragon-Gonzalez, Rafael, additional, Vega-Lopez, Francisco, additional, Wieles, Brigitte, additional, de Pena, Josefina, additional, Rodriguez, Obdulia, additional, Suarez y de la Torre, Raul, additional, de Vries, Rene R. P., additional, Ottenhoff, Tom H. M., additional, and Dockrell, Hazel M., additional

Published
2001
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35. Influenza virus vaccination induces interleukin-12/23 receptor beta 1 (IL-12/23R beta 1)-independent production of gamma interferon (IFN-gamma) and humoral immunity in patients with genetic deficiencies in IL-12/23R beta 1 or IFN-gamma receptor I.

Author

de Boer T, van Dissel JT, Kuijpers TW, Rimmelzwaan GF, Kroon FP, and Ottenhoff TH

Subjects
Adolescent, Adult, Female, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype immunology, Influenza A Virus, H3N2 Subtype immunology, Influenza B virus immunology, Influenza Vaccines administration & dosage, Middle Aged, Seasons, T-Lymphocytes immunology, Vaccination, Interferon gamma Receptor, Antibodies, Viral blood, Influenza Vaccines immunology, Influenza, Human immunology, Influenza, Human prevention & control, Interferon-gamma biosynthesis, Interleukin-12 Receptor beta 1 Subunit deficiency, Interleukin-12 Receptor beta 1 Subunit genetics, Interleukin-12 Receptor beta 1 Subunit metabolism, Receptors, Interferon deficiency, Receptors, Interferon genetics, Receptors, Interferon metabolism
Abstract

To investigate whether protective immune responses can be induced in the absence of normal interleukin-12/23/gamma interferon (IL-12/23/IFN-gamma) axis signaling, we vaccinated with the seasonal influenza virus subunit vaccine two patients with complete IL-12/23 receptor beta1 (IL-12/23R beta 1) deficiencies, two patients with partial IFN-gamma receptor I (pIFN-gamma RI) deficiencies, and five healthy controls. Blood samples were analyzed before, 7 days after, and 28 days after vaccination. In most cases, antibody titers reached protective levels. Moreover, although T-cell responses in patients were lower than those observed in controls, significant influenza virus-specific T-cell proliferation, IFN-gamma production, and numbers of IFN-gamma-producing cells were found in all patients 7 days after the vaccination. Interestingly, influenza virus-specific IFN-gamma responses were IL-12/23 independent, in striking contrast to mycobacterium-induced IFN-gamma production. In conclusion, influenza virus vaccination induces IL-12/23-independent IFN-gamma production by T cells and can result in sufficient humoral protection in both IL-12/23R beta 1- and pIFN-gamma RI-deficient individuals.

Published
2008
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36. T-cell recognition of the HspX protein of Mycobacterium tuberculosis correlates with latent M. tuberculosis infection but not with M. bovis BCG vaccination.

Author

Geluk A, Lin MY, van Meijgaarden KE, Leyten EM, Franken KL, Ottenhoff TH, and Klein MR

Subjects
Antigens, Bacterial immunology, Bacterial Proteins immunology, Humans, Mycobacterium bovis immunology, Mycobacterium bovis metabolism, Mycobacterium tuberculosis genetics, Vaccination, Antigens, Bacterial metabolism, BCG Vaccine immunology, Bacterial Proteins metabolism, Mycobacterium tuberculosis immunology, T-Lymphocytes metabolism
Abstract

During stationary growth or in vitro conditions mimicking relevant aspects of latency, the HspX protein (Rv2031c) is specifically upregulated by Mycobacterium tuberculosis. In this study we compared T-cell responses against HspX and the secreted M. tuberculosis protein Ag85B (Rv1886c) in tuberculosis (TB) patients, tuberculin skin test-positive individuals, M. bovis BCG-vaccinated individuals, and healthy negative controls. Gamma interferon responses to HspX were significantly higher in M. tuberculosis-exposed individuals than in M. tuberculosis-unexposed BCG vaccinees. In contrast, no such differences were found with respect to T-cell responses against Ag85B. Therefore, BCG-based vaccines containing relevant fragments of HspX may induce improved responses against this TB latency antigen. To identify relevant major histocompatibility complex class I- and class II-restricted HspX-specific T-cell epitopes, we immunized HLA-A2/K(b) and HLA-DR3.Ab(0) transgenic (tg) mice with HspX. Two new T-cell epitopes were identified, p91-105 and p31-50, restricted via HLA-A*0201 and HLA-DRB1*0301, respectively. These epitopes were recognized by human T cells as well, underlining the relevance of HspX T-cell recognition both in vivo and in vitro. In line with the data in humans, BCG immunization of both tg strains did not lead to T-cell responses against HspX-derived epitopes, whereas nonlatency antigens were efficiently recognized. These data support the notion that BCG vaccination per se does not induce T-cell responses against the latency antigen, HspX. Thus, we suggest that subunit vaccines incorporating HspX and/or other latency antigens, as well as recombinant BCG strains expressing latency antigens need to be considered as new vaccines against TB.

Published
2007
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37. Recognition of stage-specific mycobacterial antigens differentiates between acute and latent infections with Mycobacterium tuberculosis.

Author

Demissie A, Leyten EM, Abebe M, Wassie L, Aseffa A, Abate G, Fletcher H, Owiafe P, Hill PC, Brookes R, Rook G, Zumla A, Arend SM, Klein M, Ottenhoff TH, Andersen P, and Doherty TM

Subjects
Acute Disease, Bacterial Proteins immunology, Carrier State diagnosis, Carrier State immunology, Carrier State microbiology, Cohort Studies, Ethiopia, Gambia, Humans, Immunologic Tests, In Vitro Techniques, Interferon-gamma biosynthesis, Mycobacterium tuberculosis pathogenicity, Netherlands, Tuberculosis, Pulmonary diagnosis, Antigens, Bacterial immunology, Mycobacterium tuberculosis immunology, Tuberculosis, Pulmonary immunology, Tuberculosis, Pulmonary microbiology
Abstract

Mycobacterium tuberculosis is estimated to infect 80 to 100 million people annually, the majority of whom do not develop clinical tuberculosis (TB) but instead maintain the infection in a latent state. These individuals generally become positive in response to a tuberculin skin test and may develop clinical TB at a later date, particularly if their immune systems are compromised. Latently infected individuals are interesting for two reasons. First, they are an important reservoir of M. tuberculosis, which needs to be considered for TB control. Second, if detected prior to recrudescence of the disease, they represent a human population that is making a protective immune response to M. tuberculosis, which is very important for defining correlates of protective immunity. In this study, we show that while responsiveness to early secretory antigenic target 6 is a good marker for M. tuberculosis infection, a strong response to the 16-kDa Rv2031c antigen (HspX or alpha-crystallin) is largely restricted to latently infected individuals, offering the possibility of differential immunodiagnosis of, or therapeutic vaccination against, TB.

Published
2006
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38. Identification and characterization of the ESAT-6 homologue of Mycobacterium leprae and T-cell cross-reactivity with Mycobacterium tuberculosis.

Author

Geluk A, van Meijgaarden KE, Franken KL, Subronto YW, Wieles B, Arend SM, Sampaio EP, de Boer T, Faber WR, Naafs B, and Ottenhoff TH

Subjects
Amino Acid Sequence, Antigens, Bacterial analysis, Antigens, Bacterial chemistry, Bacterial Proteins, Cross Reactions, Humans, Interferon-gamma biosynthesis, Leprosy immunology, Molecular Sequence Data, Tuberculosis immunology, Antigens, Bacterial immunology, Mycobacterium leprae immunology, Mycobacterium tuberculosis immunology, T-Lymphocytes immunology
Abstract

In this paper we describe identification and characterization of Mycobacterium leprae ESAT-6 (L-ESAT-6), the homologue of M. tuberculosis ESAT-6 (T-ESAT-6). T-ESAT-6 is expressed by all pathogenic strains belonging to the M. tuberculosis complex but is absent from virtually all other mycobacterial species, and it is a promising antigen for immunodiagnosis of tuberculosis (TB). Therefore, we analyzed whether L-ESAT-6 is a similarly powerful tool for the study of leprosy by examining T-cell responses against L-ESAT-6 in leprosy patients, TB patients, and exposed or nonexposed healthy controls from areas where leprosy and TB are endemic and areas where they are not endemic. L-ESAT-6 was recognized by T cells from leprosy patients, TB patients, individuals who had contact with TB patients, and healthy individuals from an area where TB and leprosy are endemic but not by T cells from individuals who were not exposed to M. tuberculosis and M. leprae. Moreover, leprosy patients who were not responsive to M. leprae failed to respond to L-ESAT-6. A very similar pattern was obtained with T-ESAT-6. These results show that L-ESAT-6 is a potent M. leprae antigen that stimulates T-cell-dependent gamma interferon production in a large proportion of individuals exposed to M. leprae. Moreover, our results suggest that there is significant cross-reactivity between T-ESAT-6 and L-ESAT-6, which has implications for the use of ESAT-6 as tool for diagnosis of leprosy and TB in areas where both diseases are endemic.

Published
2002
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39. Innate immunity to Mycobacterium tuberculosis.

Author

van Crevel R, Ottenhoff TH, and van der Meer JW

Subjects
Cytokines biosynthesis, Humans, Phagocytosis, Tuberculosis immunology, Immunity, Innate, Mycobacterium tuberculosis immunology
Abstract

The different manifestations of infection with Mycobacterium tuberculosis reflect the balance between the bacillus and host defense mechanisms. Traditionally, protective immunity to tuberculosis has been ascribed to T-cell-mediated immunity, with CD4(+) T cells playing a crucial role. Recent immunological and genetic studies support the long-standing notion that innate immunity is also relevant in tuberculosis. In this review, emphasis is on these natural, innate host defense mechanisms, referring to experimental data (e.g., studies in gene knockout mice) and epidemiological, immunological, and genetic studies in human tuberculosis. The first step in the innate host defense is cellular uptake of M. tuberculosis, which involves different cellular receptors and humoral factors. Toll-like receptors seem to play a crucial role in immune recognition of M. tuberculosis, which is the next step. The subsequent inflammatory response is regulated by production of pro- and anti-inflammatory cytokines and chemokines. Different natural effector mechanisms for killing of M. tuberculosis have now been identified. Finally, the innate host response is necessary for induction of adaptive immunity to M. tuberculosis. These basic mechanisms augment our understanding of disease pathogenesis and clinical course and will be of help in designing adjunctive treatment strategies.

Published
2002
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