1. In Vitro Interactions of Antimicrobial Combinations with Fosfomycin against KPC-2-Producing Klebsiella pneumoniae and Protection of Resistance Development
- Author
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Theofano Panagea, Maria Souli, Kyriaki Kanellakopoulou, Stefanos Boukovalas, Helen Giamarellou, Zoi Chryssouli, Irene Galani, and Michael George Gourgoulis
- Subjects
medicine.drug_class ,Klebsiella pneumoniae ,Antibiotics ,Microbial Sensitivity Tests ,Biology ,Fosfomycin ,Meropenem ,beta-Lactamases ,Microbiology ,Anti-Infective Agents ,Drug Resistance, Multiple, Bacterial ,parasitic diseases ,polycyclic compounds ,medicine ,Pharmacology (medical) ,Antibacterial agent ,Pharmacology ,Colistin ,Drug Synergism ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,Antimicrobial ,biology.organism_classification ,Virology ,Infectious Diseases ,Susceptibility ,Thienamycins ,Gentamicin ,Gentamicins ,medicine.drug - Abstract
Using time-kill methodology, we investigated the interactions of fosfomycin with meropenem or colistin or gentamicin against 17 genetically distinct Klebsiella pneumoniae clinical isolates carrying bla KPC-2 . Synergy was observed with meropenem or colistin against 64.7 and 11.8% of tested isolates, while the combination with gentamicin resulted in indifference. All studied combinations showed improved bactericidal activity, compared to fosfomycin alone and prevented the development of fosfomycin resistance in 69.2, 53.8, and 81.8% of susceptible isolates, respectively.
- Published
- 2011