1. Tissue exit: a novel control point in the accumulation of antigen-specific CD8 T cells in the influenza a virus-infected lung.
- Author
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Jennrich S, Lee MH, Lynn RC, Dewberry K, and Debes GF
- Subjects
- Animals, CD8-Positive T-Lymphocytes virology, Female, Humans, Influenza A virus genetics, Influenza A virus physiology, Influenza, Human virology, Lung virology, Mice, Mice, Inbred BALB C, Mice, Knockout, Receptors, CCR7 genetics, Receptors, CCR7 immunology, CD8-Positive T-Lymphocytes immunology, Influenza A virus immunology, Influenza, Human immunology, Lung immunology
- Abstract
Memory/effector T cells efficiently migrate into extralymphoid tissues and sites of infection, providing immunosurveillance and a first line of defense against invading pathogens. Even though it is a potential means to regulate the size, quality, and duration of a tissue infiltrate, T cell egress from infected tissues is poorly understood. Using a mouse model of influenza A virus infection, we found that CD8 effector T cells egressed from the infected lung in a CCR7-dependent manner. In contrast, following antigen recognition, effector CD8 T cell egress decreased and CCR7 function was reduced in vivo and in vitro, indicating that the exit of CD8 T cells from infected tissues is tightly regulated. Our data suggest that the regulation of T cell egress is a mechanism to retain antigen-specific effectors at the site of infection to promote viral clearance, while decreasing the numbers of bystander T cells and preventing overt inflammation.
- Published
- 2012
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