1. Ribavirin small-particle aerosol treatment of infections caused by influenza virus strains A/Victoria/7/83 (H1N1) and B/Texas/1/84
- Author
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G Willis, Brian E. Gilbert, N Hayes, Samuel Z. Wilson, Robert B. Couch, Vernon Knight, Leon S. Dure, and J M Quarles
- Subjects
Male ,viruses ,medicine.medical_treatment ,Population ,Orthomyxoviridae ,Virus ,Leukocyte Count ,Random Allocation ,chemistry.chemical_compound ,Influenza A Virus, H1N1 Subtype ,Double-Blind Method ,Influenza, Human ,Ribavirin ,Humans ,Medicine ,Pharmacology (medical) ,Viral shedding ,education ,Aerosols ,Pharmacology ,Clinical Trials as Topic ,education.field_of_study ,Chemotherapy ,biology ,business.industry ,Influenzavirus B ,virus diseases ,Hemagglutination Inhibition Tests ,biology.organism_classification ,Virology ,Influenza B virus ,Infectious Diseases ,Hematocrit ,chemistry ,Influenza A virus ,Female ,Ribonucleosides ,Viral disease ,business ,Research Article - Abstract
In a double-blind study of influenza in a population of college students in 1984, ribavirin small-particle aerosol treatment of 38 patients (18 treated, 20 control) infected with a new antigenic variant, influenza virus strain A/Victoria/7/83 (H1N1), was associated with statistically significant reductions in the height and duration of fever, systemic symptoms, and virus shedding. Patients received a total of 2.4 g of ribavirin over 42 h during 68 h of hospitalization without any side effects. In addition, in a study of patients infected with influenza virus strain B/Texas/1/84 (seven treated, eight control) treated with ribavirin aerosol showed a trend of more rapid recovery than control patients.
- Published
- 1985
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