1. A Lytic Viral Long Noncoding RNA Modulates the Function of a Latent Protein
- Author
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Don Hong Wang, Steve B. Huerta, Yoshihiro Izumiya, Chie Izumiya, Pei Ching Chang, Bogdan Shevchenko, Kevin Y. Kim, Hsing Jien Kung, and Mel Campbell
- Subjects
Polyadenylation ,viruses ,Immunology ,RNA-dependent RNA polymerase ,Biology ,Medical and Health Sciences ,Microbiology ,Antigen ,Virology ,Genetics ,Humans ,Viral ,Herpesvirus 8 ,Antigens ,Antigens, Viral ,Cancer ,Agricultural and Veterinary Sciences ,Virus Activation ,Nuclear Proteins ,virus diseases ,RNA ,Herpesviridae Infections ,Biological Sciences ,biochemical phenomena, metabolism, and nutrition ,Long non-coding RNA ,Genome Replication and Regulation of Viral Gene Expression ,Infectious Diseases ,Emerging Infectious Diseases ,Lytic cycle ,Insect Science ,Herpesvirus 8, Human ,HIV/AIDS ,RNA, Viral ,Long Noncoding ,RNA, Long Noncoding ,Infection ,Function (biology) ,Human - Abstract
Latent Kaposi's sarcoma-associated herpesvirus (KSHV) episomes are coated with viral latency-associated nuclear antigen (LANA). In contrast, LANA rapidly disassociates from episomes during reactivation. Lytic KSHV expresses polyadenylated nuclear RNA (PAN RNA), a long noncoding RNA (lncRNA). We report that PAN RNA promotes LANA-episome disassociation through an interaction with LANA which facilitates LANA sequestration away from KSHV episomes during reactivation. These findings suggest that KSHV may have evolved an RNA aptamer to regulate latent protein function.
- Published
- 2014