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Start Over Author "König, W" Publisher american society for microbiology
38 results on '"König, W"'

35. Intra- and interpatient variability of the hsp65 and 16S-23S intergenic gene region in Mycobacterium abscessus strains from patients with cystic fibrosis.

Author

König B, Tammer I, Sollich V, and König W

Subjects
Adolescent, Adult, Chaperonin 60, Child, Female, Humans, Male, Molecular Sequence Data, Mycobacterium chelonae genetics, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, RNA, Ribosomal, 16S genetics, RNA, Ribosomal, 23S genetics, Sequence Analysis, DNA, Sputum microbiology, Bacterial Proteins genetics, Chaperonins genetics, Cystic Fibrosis microbiology, DNA, Ribosomal Spacer analysis, Genetic Variation, Mycobacterium Infections, Nontuberculous microbiology, Mycobacterium chelonae classification
Abstract

To establish the exact pathogenic role of Mycobacterium abscessus in cystic fibrosis (CF), molecular tests are required for accurate identification. Forty-eight M. abscessus isolates from seven patients with CF were analyzed by sequence analysis for sequence variants within the hsp65 gene and the 16S-23S intergenic sequence (ITS). We detected two different hsp65 genes and correspondingly two ITS sequevars belonging to M. abscessus type I and type II.

Published
2005
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36. Prospective study of human metapneumovirus infection in children less than 3 years of age.

Author

König B, König W, Arnold R, Werchau H, Ihorst G, and Forster J

Subjects
Child, Preschool, Germany epidemiology, Humans, Infant, Infant, Newborn, Paramyxoviridae Infections complications, Paramyxoviridae Infections virology, Prospective Studies, Respiratory Syncytial Virus Infections complications, Respiratory Syncytial Virus Infections virology, Respiratory Syncytial Virus, Human isolation & purification, Respiratory Tract Infections physiopathology, Respiratory Tract Infections virology, Severity of Illness Index, Metapneumovirus isolation & purification, Paramyxoviridae Infections epidemiology, Respiratory Syncytial Virus Infections epidemiology, Respiratory Tract Infections epidemiology
Abstract

Most lower respiratory tract infections (LRTIs) in children under the age of 3 years are due to respiratory syncytial virus (RSV). Epidemiological, host, and viral factors eventually account for the severity of LRTIs, but they do not completely explain it. Human metapneumovirus (hMPV) was recently identified in children with LRTIs. In a population-based prospective multicenter study (the PRI.DE study, conducted in Germany over 2 years), we tested 3,369 nasopharyngeal secretions from children younger than 3 years of age with LRTIs for RSV A and B, influenza viruses (IVs) A and B, and parainfluenza viruses (PIVs) 1 to 3. Of the children requiring intensive care (n = 85), 18% had hMPV infections, and 60% of these children were infected with hMPV in combination with RSV. We did not detect hMPV in a randomly selected subset of RSV-positive nasopharyngeal secretions (n = 120) from children not requiring intensive care support. hMPV was detected in <1% of virus-negative samples from patients without intensive care support (n = 620). Our data support the hypothesis that coinfections with RSV and hMPV are more severe than infections with either RSV or hMPV alone, at least in children younger than 3 years of age.

Published
2004
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37. Helicobacter pylori induces AGS cell motility and elongation via independent signaling pathways.

Author

Moese S, Selbach M, Kwok T, Brinkmann V, König W, Meyer TF, and Backert S

Subjects
Antigens, Bacterial genetics, Antigens, Bacterial metabolism, Bacterial Proteins genetics, Bacterial Proteins metabolism, Cells, Cultured, Cytoskeleton metabolism, Epithelial Cells ultrastructure, Gastric Mucosa cytology, Gene Expression Regulation, Bacterial, Helicobacter pylori genetics, Humans, Transfection, Virulence, Cell Movement, Epithelial Cells microbiology, Gastric Mucosa microbiology, Helicobacter pylori pathogenicity, Signal Transduction
Abstract

Helicobacter pylori induces motogenic and cytoskeletal responses in gastric epithelial cells. We demonstrate that these responses can be induced via independent signaling pathways that often occur in parallel. The cag pathogenicity island appears to be nonessential for induction of motility, whereas the elongation phenotype depends on translocation and phosphorylation of CagA.

Published
2004
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38. Disseminated infection due to Blastobacter denitrificans following routine appendectomy in an adolescent.

Author

Trotha R, Guenther G, König W, and König B

Subjects
Child, Female, Humans, Alphaproteobacteria isolation & purification, Appendectomy adverse effects, Gram-Negative Bacterial Infections microbiology, Opportunistic Infections microbiology
Abstract

Until now, Blastobacter denitrificans has not been mentioned in the context of human infections. A case of severe complication caused by B. denitrificans after routine appendectomy in a young girl is described and confirms this organism to be an opportunistic human pathogen.

Published
2002
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