1. Influence of Host Factors on Immunoglobulin G Concentration in Oral Fluid Specimens
- Author
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Bharat Parekh, Wendy Kitson-Piggott, Perry Gomez, James Baggs, J. Richard George, Susan Phillips, Timothy C. Granade, Herbert Oleander, and Bisram Mahabir
- Subjects
Adult ,Male ,Microbiology (medical) ,medicine.medical_specialty ,Diagnostic methods ,Tobacco use ,Adolescent ,Clinical Biochemistry ,Immunology ,Mouthwashes ,Human immunodeficiency virus (HIV) ,Antibodies and Mediators of Immunity ,HIV Infections ,Host factors ,medicine.disease_cause ,Gastroenterology ,Immunoglobulin G ,Internal medicine ,medicine ,Dentition ,Humans ,Immunology and Allergy ,Child ,Periodontal Diseases ,Aged ,Mouth ,Meal ,biology ,business.industry ,Smoking ,Infant, Newborn ,Infant ,Middle Aged ,Child, Preschool ,Multivariate Analysis ,biology.protein ,Oral fluid ,Female ,Antibody ,business - Abstract
The influence of host factors (tobacco use, dentition, bleeding gums, oral rinsing, nasal medications, and time since the last meal) on immunoglobulin G (IgG) concentration in oral fluids (OF) was determined by univariate and multivariate analysis. Significant differences in IgG concentration were found to be associated with human immunodeficiency virus (HIV) status (HIV antibody positive, +16.60 μg/ml, P = 0.0001), sex (female, +1.23 μg/ml, P = 0.004), dentition (+2.83 μg/ml, edentulous versus dentulous, P = 0.0001), bleeding gums (+6.35 μg/ml, P = 0.0001), and time since the last meal (+3.55 μg/ml, >6 h, P = 0.0001). These factors could impact diagnostic methods that rely on the immunoglobulin concentration in OF specimens.
- Published
- 2002
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