1. Disseminated simian varicella virus infection in an irradiated rhesus macaque (Macaca mulatta).
- Author
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Kolappaswamy K, Mahalingam R, Traina-Dorge V, Shipley ST, Gilden DH, Kleinschmidt-Demasters BK, McLeod CG Jr, Hungerford LL, and DeTolla LJ
- Subjects
- Animals, Herpesviridae Infections pathology, Herpesviridae Infections virology, Gamma Rays, Herpesviridae Infections veterinary, Macaca mulatta virology, Monkey Diseases pathology, Monkey Diseases virology, Varicellovirus radiation effects
- Abstract
We describe correlative clinicopathological/virological findings from a simian varicella virus (SVV)-seronegative monkey that developed disseminated varicella 105 days after gamma-irradiation. Twelve other monkeys in the colony were also irradiated, none of which developed varicella. Before irradiation, sera from the monkey that developed disseminated infection and one asymptomatic monkey were available. Analysis indicated that subclinical reactivation of latent SVV from an asymptomatic irradiated monkey likely led to disseminated varicella in the seronegative irradiated monkey. These findings parallel those from humans with disseminated varicella infection and support the usefulness of SVV infection as a model for human varicella-zoster virus infection, particularly virus reactivation after gamma-irradiation.
- Published
- 2007
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