1. Pseudomonas aeruginosa producing FIM-1-metallo-β-lactamase: emergence and cross-transmission in a long-term acute care rehabilitation hospital.
- Author
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Antonelli A, Coppi M, Bonaiuto C, Giovacchini N, Grifoni C, Vaggelli G, Pupillo R, Vannetti F, Farese A, Viaggi B, Pollini S, and Rossolini GM
- Subjects
- Humans, Microbial Sensitivity Tests, Hospitals, Rehabilitation, Cross Infection microbiology, Male, Pseudomonas aeruginosa genetics, Pseudomonas aeruginosa drug effects, beta-Lactamases genetics, beta-Lactamases metabolism, Pseudomonas Infections microbiology, Pseudomonas Infections drug therapy, Whole Genome Sequencing, Anti-Bacterial Agents pharmacology
- Abstract
FIM-1 metallo-β-lactamase was previously detected in sporadic Pseudomonas aeruginosa clinical isolates. Here, we report on FIM-1-positive P. aeruginosa from two patients who had shared the same ward in a long-term acute care rehabilitation hospital. Whole-genome sequencing analysis revealed close relatedness of these isolates, which belonged to an ST235 sublineage (clade 8/14) different from those previously reported. Results highlighted the occurrence of clonal diversity among FIM-positive strains and the possibility of their cross-transmission in some healthcare settings., Competing Interests: The authors declare no conflict of interest.
- Published
- 2024
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