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Your search keyword '"Dunford L"' showing total 2 results
Start Over Author "Dunford L" Publisher american society for microbiology
2 results on '"Dunford L"'

1. Hepatitis C Virus Core Mutations Associated with False-Negative Serological Results for Genotype 3a Core Antigen.

Author

Nguyen LT, Dunford L, Freitas I, Holder P, Nguyen LA, O'Gorman J, Connell J, Carr M, Hall W, and De Gascun C

Subjects
Antigens, Viral genetics, Genotype, Humans, False Negative Reactions, Hepacivirus isolation & purification, Hepatitis C diagnosis, Mutant Proteins genetics, Mutation, Missense, Serologic Tests methods, Viral Core Proteins genetics
Abstract

Genetic characterization of the genotype 3a (GT3a) hepatitis C virus (HCV) core region from HCV core antigen (HCVcAg)-negative/RNA-positive cases and HCVcAg-positive/RNA-positive controls identified significant associations between the substitutions A48T and T49A/P and failure to detect HCVcAg (P < 0.05). Polymorphisms at residues 48 and 49 in the core protein are present across all major epidemic and endemic GTs. These findings have implications for HCV diagnosis, particularly in low-income regions in which GT3a HCV is endemic., (Copyright © 2015, Nguyen et al.)

Published
2015
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2. First report of sudden death due to myocarditis caused by adenovirus serotype 3.

Author

Treacy A, Carr MJ, Dunford L, Palacios G, Cannon GA, O'Grady A, Moran J, Hassan J, Loy A, Connell J, Devaney D, Kelehan P, and Hall WW

Subjects
Adenoids pathology, Adenovirus Infections, Human virology, Adenoviruses, Human genetics, Child, DNA, Viral chemistry, DNA, Viral genetics, Histocytochemistry, Humans, Immunohistochemistry, Male, Microscopy, Molecular Sequence Data, Myocarditis virology, Myocardium pathology, Sequence Analysis, DNA, Systemic Inflammatory Response Syndrome pathology, Adenovirus Infections, Human diagnosis, Adenoviruses, Human isolation & purification, Death, Sudden etiology, Myocarditis diagnosis
Abstract

Myocarditis is a rare cause of sudden death in childhood. We describe the sudden death of a child from viral myocarditis, which we demonstrate was likely caused by an uncontrolled inflammatory response to a disseminated adenovirus serotype 3 infection originating in the tonsil.

Published
2010
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