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Start Over Author "Cunningham, Adam F" Publisher american society for microbiology
18 results on '"Cunningham, Adam F"'

1. Efficient Autotransporter-Mediated Extracellular Secretion of a Heterologous Recombinant Protein by Escherichia coli

Author

Beriotto, Irene, primary, Icke, Christopher, additional, Sevastsyanovich, Yanina R., additional, Rossiter, Amanda E., additional, Romagnoli, Giacomo, additional, Savino, Silvana, additional, Hodges, Freya J., additional, Cole, Jeffrey A., additional, Saul, Allan, additional, MacLennan, Calman A., additional, Cunningham, Adam F., additional, Micoli, Francesca, additional, and Henderson, Ian R., additional

Published
2023
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2. LI-Detector: a Method for Curating Ordered Gene-Replacement Libraries

Author

Goodall, Emily C. A., primary, Morris, Faye C., additional, McKeand, Samantha A., additional, Sullivan, Rudi, additional, Warner, Isabel A., additional, Sheehan, Emma, additional, Boelter, Gabriela, additional, Icke, Christopher, additional, Cunningham, Adam F., additional, Cole, Jeffrey A., additional, Banzhaf, Manuel, additional, Bryant, Jack A., additional, and Henderson, Ian R., additional

Published
2022
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4. A commensal gone bad: complete genome sequence of the prototypical enterotoxigenic Escherichia coli strain H10407

Author

Crossman, Lisa C., Chaudhuri, Roy R., Beatson, Scott A., Wells, Timothy J., Desvaux, Mickael, Cunningham, Adam F., Petty, Nicola K., Mahon, Vivienne, Brinkley, Carl, Hobman, Jon L., Savarino, Stephen J., Turner, Susan M., Pallen, Mark J., Penn, Charles W., Parkhill, Julian, Turner, A. Keith, Johnson, Timothy J., Thomson, Nicholas R., Smith, Stephen G.J., and Henderson, Ian R.

Subjects
Bacterial genetics -- Research, Escherichia coli -- Genetic aspects, Genomes -- Identification and classification, Biological sciences
Abstract

In most cases, Escherichia coli exists as a harmless commensal organism, but it may on occasion cause intestinal and/or extraintestinal disease. Enterotoxigenic E. coli (ETEC) is the predominant cause of E. coli-mediated diarrhea in the developing world and is responsible for a significant portion of pediatric deaths. In this study, we determined the complete genomic sequence of E. coli H10407, a prototypical strain of enterotoxigenic E. coli, which reproducibly elicits diarrhea in human volunteer studies. We performed genomic and phylogenetic comparisons with other E. coli strains, revealing that the chromosome is closely related to that of the nonpathogenic commensal strain E. coli HS and to those of the laboratory strains E. coli K-12 and C. Furthermore, these analyses demonstrated that there were no chromosomally encoded factors unique to any sequenced ETEC strains. Comparison of the E. coli H10407 plasmids with those from several ETEC strains revealed that the plasmids had a mosaic structure but that several loci were conserved among ETEC strains. This study provides a genetic context for the vast amount of experimental and epidemiological data that have been published. doi: 10.1128/JB.00710-10

Published
2010

5. Structure-Function Characterization of the Conserved Regulatory Mechanism of the Escherichia coli M48 Metalloprotease BepA

Author

Bryant, Jack A., primary, Cadby, Ian T., additional, Chong, Zhi-Soon, additional, Boelter, Gabriela, additional, Sevastsyanovich, Yanina R., additional, Morris, Faye C., additional, Cunningham, Adam F., additional, Kritikos, George, additional, Meek, Richard W., additional, Banzhaf, Manuel, additional, Chng, Shu-Sin, additional, Lovering, Andrew L., additional, and Henderson, Ian R., additional

Published
2020
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6. Mycobacterial stationary phase induced by low oxygen tension: cell wall thickening and localization of the 16-kilodalton alpha-crystallin homolog

Author

Cunningham, Adam F. and Spreadbury, Claire L.

Subjects
Mycobacterium tuberculosis -- Research, Dormancy (Biology) -- Research, Bacterial cell walls -- Analysis, Biological sciences
Abstract

Research was conducted to analyze the ability of Mycobacterium tuberculosis bacteria to survive a state of dormancy. This study required the culture of M. tuberculosis H37Rv and Mycobacterium bovis BCG under anaerobic, microaerobic and aerobic conditions. Observations of the bacteria's ultrastructural morphology revealed a thickening of the cell wall outer layer of the the cultured bacilli excepted for the aerobically cultured ones.

Published
1998

7. YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium

Author

Morris, Faye C., primary, Wells, Timothy J., additional, Bryant, Jack A., additional, Schager, Anna E., additional, Sevastsyanovich, Yanina R., additional, Squire, Derrick J. P., additional, Marshall, Jennifer, additional, Isom, Georgia L., additional, Rooke, Jessica, additional, Maderbocus, Riyaz, additional, Knowles, Timothy J., additional, Overduin, Michael, additional, Rossiter, Amanda E., additional, Cunningham, Adam F., additional, and Henderson, Ian R., additional

Published
2018
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8. IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal Salmonella Develop at Discordant Rates

Author

Schager, Anna E., primary, Dominguez-Medina, C. Coral, additional, Necchi, Francesca, additional, Micoli, Francesca, additional, Goh, Yun Shan, additional, Goodall, Margaret, additional, Flores-Langarica, Adriana, additional, Bobat, Saeeda, additional, Cook, Charlotte N. L., additional, Arcuri, Melissa, additional, Marini, Arianna, additional, King, Lloyd D. W., additional, Morris, Faye C., additional, Anderson, Graham, additional, Toellner, Kai-Michael, additional, Henderson, Ian R., additional, López-Macías, Constantino, additional, MacLennan, Calman A., additional, and Cunningham, Adam F., additional

Published
2018
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9. The Essential Genome of Escherichia coli K-12

Author

Goodall, Emily C. A., primary, Robinson, Ashley, additional, Johnston, Iain G., additional, Jabbari, Sara, additional, Turner, Keith A., additional, Cunningham, Adam F., additional, Lund, Peter A., additional, Cole, Jeffrey A., additional, and Henderson, Ian R., additional

Published
2018
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10. Complete Closed Genome Sequence of Nontoxigenic Invasive Corynebacterium diphtheriae bv. mitis Strain ISS 3319

Author

Azevedo Antunes, Camila, primary, Richardson, Emily J., additional, Quick, Joshua, additional, Fuentes-Utrilla, Pablo, additional, Isom, Georgia L., additional, Goodall, Emily C., additional, Möller, Jens, additional, Hoskisson, Paul A., additional, Mattos-Guaraldi, Ana Luiza, additional, Cunningham, Adam F., additional, Loman, Nicholas J., additional, Sangal, Vartul, additional, Burkovski, Andreas, additional, and Henderson, Ian R., additional

Published
2018
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11. Antigen Localization Influences the Magnitude and Kinetics of Endogenous Adaptive Immune Response to Recombinant Salmonella Vaccines

Author

Sevastsyanovich, Yanina R., primary, Withers, David R., additional, Marriott, Claire L., additional, Morris, Faye C., additional, Wells, Timothy J., additional, Browning, Douglas F., additional, Beriotto, Irene, additional, Ross, Ewan, additional, Ali, Hossam Omar, additional, Wardius, Catherine A., additional, Cunningham, Adam F., additional, Henderson, Ian R., additional, and Rossiter, Amanda E., additional

Published
2017
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12. SadA, a Trimeric Autotransporter from Salmonella enterica Serovar Typhimurium, Can Promote Biofilm Formation and Provides Limited Protection against Infection

Author

Raghunathan, Dhaarini, primary, Wells, Timothy J., additional, Morris, Faye C., additional, Shaw, Robert K., additional, Bobat, Saeeda, additional, Peters, Sarah E., additional, Paterson, Gavin K., additional, Jensen, Karina Tveen, additional, Leyton, Denisse L., additional, Blair, Jessica M. A., additional, Browning, Douglas F., additional, Pravin, John, additional, Flores-Langarica, Adriana, additional, Hitchcock, Jessica R., additional, Moraes, Claudia T. P., additional, Piazza, Roxane M. F., additional, Maskell, Duncan J., additional, Webber, Mark A., additional, May, Robin C., additional, MacLennan, Calman A., additional, Piddock, Laura J., additional, Cunningham, Adam F., additional, and Henderson, Ian R., additional

Published
2011
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13. Complete Genome Sequence of the Crohn's Disease-Associated Adherent-Invasive Escherichia coliStrain HM605

Author

Clarke, David J., primary, Chaudhuri, Roy R., additional, Martin, Helen M., additional, Campbell, Barry J., additional, Rhodes, Jonathan M., additional, Constantinidou, Chrystala, additional, Pallen, Mark J., additional, Loman, Nicholas J., additional, Cunningham, Adam F., additional, Browning, Douglas F., additional, and Henderson, Ian R., additional

Published
2011
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14. The Essential β-Barrel Assembly Machinery Complex Components BamD and BamA Are Required for Autotransporter Biogenesis

Author

Rossiter, Amanda E., primary, Leyton, Denisse L., additional, Tveen-Jensen, Karina, additional, Browning, Douglas F., additional, Sevastsyanovich, Yanina, additional, Knowles, Timothy J., additional, Nichols, Katie B., additional, Cunningham, Adam F., additional, Overduin, Michael, additional, Schembri, Mark A., additional, and Henderson, Ian R., additional

Published
2011
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15. Genome Sequence of the Emerging Pathogen Aeromonas caviae

Author

Beatson, Scott A., primary, das Graças de Luna, Maria, additional, Bachmann, Nathan L., additional, Alikhan, Nabil-Fareed, additional, Hanks, Kirstin R., additional, Sullivan, Mitchell J., additional, Wee, Bryan A., additional, Freitas-Almeida, Angela C., additional, dos Santos, Paula A., additional, de Melo, Janyne T. B., additional, Squire, Derrick J. P., additional, Cunningham, Adam F., additional, Fitzgerald, J. Ross, additional, and Henderson, Ian R., additional

Published
2011
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17. Structure-Function Characterization of the Conserved Regulatory Mechanism of the Escherichia coli M48 Metalloprotease BepA.

Author

Bryant, Jack A., Cadby, Ian T., Zhi-Soon Chong, Boelter, Gabriela, Sevastsyanovich, Yanina R., Morris, Faye C., Cunningham, Adam F., Kritikos, George, Meek, Richard W., Banzhaf, Manuel, Shu-Sin Chng, Lovering, Andrew L., and Henderson, Ian R.

Abstract

The asymmetric Gram-negative outer membrane (OM) is the first line of defense for bacteria against environmental insults and attack by antimicrobials. The key component of the OM is lipopolysaccharide, which is transported to the surface by the essential lipopolysaccharide transport (Lpt) system. Correct folding of the Lpt system component LptD is regulated by a periplasmic metalloprotease, BepA. Here, we present the crystal structure of BepA from Escherichia coli, solved to a resolution of 2.18 Å, in which the M48 protease active site is occluded by an active-site plug. Informed by our structure, we demonstrate that free movement of the active-site plug is essential for BepA function, suggesting that the protein is autoregulated by the active-site plug, which is conserved throughout the M48 metalloprotease family. Targeted mutagenesis of conserved residues reveals that the negative pocket and the tetratricopeptide repeat (TPR) cavity are required for function and degradation of the BAM complex component BamA under conditions of stress. Last, we show that loss of BepA causes disruption of OM lipid asymmetry, leading to surface exposed phospholipid. [ABSTRACT FROM AUTHOR]

Published
2021
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18. Complete Genome Sequence of the Crohn's Disease-Associated Adherent-Invasive Escherichia coli Strain HM605.

Author

Clarke, David J., Chaudhuri, Roy R., Martin, Helen M., Campbell, Barry J., Rhodes, Jonathan M., Constantinidou, Chrystala, Pallen, Mark J., Loman, Nicholas J., Cunningham, Adam F., Browning, Douglas F., and Henderson, Ian R.

Subjects
*ESCHERICHIA coli, *GASTROINTESTINAL diseases, *CROHN'S disease, *NUCLEOTIDE sequence, *BIOPSY
Abstract

Adherent-invasive Escherichia coli strains are increasingly being associated with intestinal pathologies. Here we present the genome sequence of E. coli HM605, a strain isolated from colonic biopsy specimens of a patient with Crohn's disease. [ABSTRACT FROM AUTHOR]

Published
2011
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