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Your search keyword '"Belshe, Robert"' showing total 12 results
Start Over Author "Belshe, Robert" Publisher american society for microbiology
12 results on '"Belshe, Robert"'

2. Comparisons of the Humoral and Cellular Immune Responses Induced by Live Attenuated Influenza Vaccine and Inactivated Influenza Vaccine in Adults

Author

Hoft, Daniel F., primary, Lottenbach, Kathleen R., additional, Blazevic, Azra, additional, Turan, Aldin, additional, Blevins, Tamara P., additional, Pacatte, Thomas P., additional, Yu, Yinyi, additional, Mitchell, Michelle C., additional, Hoft, Stella G., additional, and Belshe, Robert B., additional

Published
2017
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3. Recombinant Hepatitis C Virus Envelope Glycoprotein Vaccine Elicits Antibodies Targeting Multiple Epitopes on the Envelope Glycoproteins Associated with Broad Cross-Neutralization

Author

Wong, Jason Alexander Ji-Xhin, primary, Bhat, Rakesh, additional, Hockman, Darren, additional, Logan, Michael, additional, Chen, Chao, additional, Levin, Aviad, additional, Frey, Sharon E., additional, Belshe, Robert B., additional, Tyrrell, D. Lorne, additional, Law, John Lok Man, additional, and Houghton, Michael, additional

Published
2014
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5. Seroepidemiology of Astrovirus MLB1

Author

Holtz, Lori R., primary, Bauer, Irma K., additional, Jiang, Hongbing, additional, Belshe, Robert, additional, Freiden, Pamela, additional, Schultz-Cherry, Stacey L., additional, and Wang, David, additional

Published
2014
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12. Recombinant Hepatitis C Virus Envelope Glycoprotein Vaccine Elicits Antibodies Targeting Multiple Epitopes on the Envelope Glycoproteins Associated with Broad Cross-Neutralization.

Author

Ji-Xhin Wong, Jason Alexander, Bhat, Rakesh, Hockman, Darren, Logan, Michael, Chao Chen, Levin, Aviad, Frey, Sharon E., Belshe, Robert B., Tyrrell, D. Lorne, Man Law, John Lok, and Houghton, Michael

Subjects
*HEPATITIS C virus, *GLYCOPROTEINS, *IMMUNOGLOBULINS, *TARGETED drug delivery, *EPITOPES, *ANTIVIRAL agents
Abstract

Although effective hepatitis C virus (HCV) antivirals are on the horizon, a global prophylactic vaccine for HCV remains elusive. The diversity of the virus is a major concern for vaccine development; there are 7 major genotypes of HCV found globally. Therefore, a successful vaccine will need to protect against HCV infection by all genotypes. Despite the diversity, many monoclonal antibodies (MAbs) with broadly cross-neutralizing activity have been described, suggesting the presence of conserved epitopes that can be targeted to prevent infection. Similarly, a vaccine comprising recombinant envelope glycoproteins (rE1E2) derived from the genotype 1a HCV-1 strain has been shown to be capable of eliciting cross-neutralizing antibodies in guinea pigs, chimpanzees, and healthy human volunteers. In order to investigate the basis for this cross-neutralization, epitope mapping of anti- E1E2 antibodies present within antisera from goats and humans immunized with HCV-1 rE1E2 was conducted through peptide mapping and competition studies with a panel of cross-neutralizing MAbs targeting various epitopes within E1E2. The immunized- goat antiserum was shown to compete with the binding of all MAbs tested (AP33, HC33.4, HC84.26, 1:7, AR3B, AR4A, AR5A, IGH526, and A4). Antisera showed the best competition against HC84.26 and AR3B and the weakest competition against AR4A. Furthermore, antisera from five immunized human vaccinees were shown to compete with five preselected MAbs (AP33, AR3B, AR4A, AR5A, and IGH526). These data show that immunization with HCV-1 rE1E2 elicits antibodies targeting multiple cross-neutralizing epitopes. Our results further support the use of such a vaccine antigen to induce cross-genotype neutralization. [ABSTRACT FROM AUTHOR]

Published
2014
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