1. Protective Capacity of Virus-Specific T Cell Receptor-Transduced CD8 T Cells In Vivo
- Author
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Ulrike Aichele, Hanspeter Pircher, Katja Mueller, Lilian Stärck, Wolfgang Uckert, Matthias Leisegang, and Anne von Mässenhausen
- Subjects
Immunology ,Receptors, Antigen, T-Cell ,Streptamer ,Biology ,CD8-Positive T-Lymphocytes ,Microbiology ,Interleukin 21 ,Gene Delivery ,Interferon-gamma ,Mice ,Viral Proteins ,Virology ,Cytotoxic T cell ,Animals ,Lymphocytic choriomeningitis virus ,IL-2 receptor ,Lymphocytes ,Antigens ,Antigen-presenting cell ,Antigens, Viral ,Interleukin 3 ,Glycoproteins ,ZAP70 ,Cell Membrane ,Natural killer T cell ,Flow Cytometry ,Molecular biology ,Listeria monocytogenes ,Peptide Fragments ,Phenotype ,Retroviridae ,Insect Science ,Cytokines ,Spleen - Abstract
The transfer of T cell receptor (TCR) genes by viral vectors represents a promising technique to generate antigen-specific T cells for adoptive immunotherapy. TCR-transduced T cells specific for infectious pathogens have been described, but their protective function in vivo has not yet been examined. Here, we demonstrate that CD8 T cells transduced with the P14 TCR specific for the gp33 epitope of lymphocytic choriomeningitis virus exhibit protective activities in both viral and bacterial infection models in mice.
- Published
- 2012