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Start Over Author "Andrew G. Evans" Publisher american society for microbiology
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1. The Absence of M1 Leads to Increased Establishment of Murine Gammaherpesvirus 68 Latency in IgD-Negative B Cells

Author

Andrew G. Evans, Samuel H. Speck, Laurie T. Krug, Clinton R. Paden, and Lisa M. Gargano

Subjects
Rhadinovirus, T cell, Immunology, M1 protein, Microbiology, Immunoglobulin D, Virus, Mice, Viral Proteins, Virology, medicine, Animals, Latency (engineering), B-Lymphocytes, Mice, Inbred BALB C, biology, Effector, Molecular biology, Virus Latency, Mice, Inbred C57BL, Chronic infection, medicine.anatomical_structure, Insect Science, biology.protein, Pathogenesis and Immunity, CD8
Abstract

The secreted M1 protein of murine gammaherpesvirus 68 (MHV68) promotes effector Vβ4 + CD8 + T cell expansion to impact virus control and immune-mediated pathologies in C57BL/6 mice, but not BALB/c mice. We report a striking increase in the number of genome-positive, IgD − B cells during chronic infection of both mouse strains. This suggests a novel role for M1 in influencing long-term maintenance in a major latency reservoir irrespective of the degree of Vβ4 + CD8 + T cell expansion.

Published
2013

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