1. Fonsecaea pugnacius, a Novel Agent of Disseminated Chromoblastomycosis.
- Author
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de Azevedo CM, Gomes RR, Vicente VA, Santos DW, Marques SG, do Nascimento MM, Andrade CE, Silva RR, Queiroz-Telles F, and de Hoog GS
- Subjects
- Ascomycota genetics, Brain microbiology, Brain pathology, Brazil, Chromoblastomycosis microbiology, Cluster Analysis, DNA, Fungal chemistry, DNA, Fungal genetics, DNA, Ribosomal chemistry, DNA, Ribosomal genetics, DNA, Ribosomal Spacer chemistry, DNA, Ribosomal Spacer genetics, Fatal Outcome, Head diagnostic imaging, Histocytochemistry, Humans, Magnetic Resonance Imaging, Male, Microscopy, Middle Aged, Molecular Sequence Data, Phylogeny, RNA, Ribosomal genetics, Radiography, Sequence Analysis, DNA, Skin microbiology, Skin pathology, White People, Ascomycota classification, Ascomycota isolation & purification, Chromoblastomycosis diagnosis, Chromoblastomycosis pathology
- Abstract
We report a fatal case of a chromoblastomycosis-like infection caused by a novel species of Fonsecaea in a 52-year-old immunocompetent Caucasian male from an area of chromoblastomycosis endemicity in Brazil. The patient had a 30-year history of slowly evolving, verrucous lesions on the right upper arm which gradually affected the entire arm, the left hemifacial area, and the nose. Subsequent dissemination to the brain was observed, which led to death of the patient. The internal transcribed spacer (ITS) and partial large subunit (LSU), BT2, and CDC42 genes of the isolates recovered from skin and brain were sequenced, confirming the novelty of the species. The species is clinically unique in causing brain abscesses secondary to chromoblastomycosis lesions despite the apparent intact immunity of the patient. Histopathologic appearances were very different, showing muriform cells in skin and hyphae in brain., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Published
- 2015
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