1. Nigrograna mackinnonii, Not Trematosphaeria grisea (syn., Madurella grisea), Is the Main Agent of Black Grain Eumycetoma in Latin America.
- Author
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Ahmed SA, González GM, Tirado-Sánchez A, Moreno-López LM, de Hoog S, and Bonifaz A
- Subjects
- Adult, Antifungal Agents therapeutic use, Ascomycota isolation & purification, DNA, Fungal genetics, DNA, Ribosomal genetics, Female, Humans, Itraconazole therapeutic use, Latin America, Madurella classification, Madurella genetics, Male, Mexico, Middle Aged, Mycetoma diagnosis, Mycetoma drug therapy, Mycetoma pathology, Sequence Analysis, DNA, Treatment Outcome, Ascomycota classification, Ascomycota genetics, Mycetoma microbiology, Phylogeny
- Abstract
Mycetoma, a chronic and mutilating subcutaneous infection recognized by the WHO as a neglected tropical disease, has been reported in >25 countries in Africa, Asia, and South America. In Latin America, Trematosphaeria grisea is assumed to be the prevalent fungal agent. Recent molecular studies have shown that this is an environmental saprobe in Europe, where it is rarely implicated in human diseases. The aim of the present paper is to establish the identity of Latin American cases ascribed to Trematosphaeria grisea Three cases analyzed were caused by Nigrograna mackinnonii Data on an additional 21 strains in the literature revealed that N. mackinnonii rather than T. grisea is responsible for most cases of black grain eumycetoma in Latin America., (Copyright © 2018 American Society for Microbiology.)
- Published
- 2018
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