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Your search keyword '"Haiqing Shen"' showing total 2 results
Start Over Author "Haiqing Shen" Publisher american society for clinical investigation
2 results on '"Haiqing Shen"'

1. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels

Author

Laura J. Scott, Natascia Sestu, Serena Sanna, Karen L. Mohlke, Gitte Andersen, Nicholas J. Timpson, Richard M. Watanabe, Marco Orrù, Braxton D. Mitchell, Manuela Uda, Valeriya Lyssenko, Torben Jørgensen, Wei-Min Chen, Heather M. Stringham, Amy J. Swift, Thomas A. Buchanan, Nazario Olla, Jouko Saramies, Samer S. Najjar, Jaakko Tuomilehto, Haiqing Shen, Alan R. Shuldiner, David Schlessinger, Anne U. Jackson, Richard N. Bergman, Oluf Pedersen, Torben Hansen, William L. Duren, Michael Boehnke, Antonio Cao, George Davey Smith, Maria Cristina Spada, Edward G. Lakatta, Knut Borch-Johnsen, Leif Groop, Johanna Kuusisto, David Altshuler, Francis S. Collins, Cristen J. Willer, Kristi D. Silver, Markku Laakso, Yoav Ben-Shlomo, Michael R. Erdos, Angelo Scuteri, Timo T. Valle, Maria Grazia Piras, Gonçalo R. Abecasis, Lori L. Bonnycastle, Debbie A Lawlor, Richa Saxena, and Shah Ebrahim

Subjects
Adult, Blood Glucose, medicine.medical_specialty, Genotype, G6PC2, 030209 endocrinology & metabolism, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Linkage Disequilibrium, White People, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Diabetes mellitus, Internal medicine, medicine, Humans, SNP, ABCB11, Allele, Allele frequency, ATP Binding Cassette Transporter, Subfamily B, Member 11, Finland, Aged, 030304 developmental biology, Analysis of Variance, 0303 health sciences, biology, Fasting, General Medicine, Middle Aged, medicine.disease, Endocrinology, Italy, Glucose-6-Phosphatase, biology.protein, ATP-Binding Cassette Transporters, Glucose 6-phosphatase, Research Article, Follow-Up Studies
Abstract

Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 x 10(-7)). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 x 10(-26), and combining results from all studies resulted in an overall P value for association of 6.4 x 10(-33). Across these studies, fasting glucose concentrations increased 0.01-0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation.

Published
2008

2. Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels.

Author

Wei-Min Chen, Erdos, Michael R., Jackson, Anne U., Saxena, Richa, Sanna, Serena, Silver, Kristi D., Timpson, Nicholas J., Hansen, Torben, Orrù, Marco, Piras, Maria Grazia, Bonnycastle, Lori L., Willer, Cristen J., Lyssenko, Valeriya, Haiqing Shen, Kuusisto, Johanna, Ebrahim, Shah, Sestu, Natascia, Duren, William L., Spada, Maria Cristina, and Stringham, Heather M.

Subjects
*GLUCOSE, *DIABETES, *GLUCOSE-6-phosphatase, *ATP-binding cassette transporters, *BLOOD sugar analysis, *ANALYSIS of variance, *CARRIER proteins, *COMPARATIVE studies, *FASTING, *GENES, *GENETIC polymorphisms, *GENETICS, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *PHOSPHATASES, *RESEARCH, *RESEARCH funding, *WHITE people, *EVALUATION research, *GENOTYPES
Abstract

Identifying the genetic variants that regulate fasting glucose concentrations may further our understanding of the pathogenesis of diabetes. We therefore investigated the association of fasting glucose levels with SNPs in 2 genome-wide scans including a total of 5,088 nondiabetic individuals from Finland and Sardinia. We found a significant association between the SNP rs563694 and fasting glucose concentrations (P = 3.5 x 10(-7)). This association was further investigated in an additional 18,436 nondiabetic individuals of mixed European descent from 7 different studies. The combined P value for association in these follow-up samples was 6.9 x 10(-26), and combining results from all studies resulted in an overall P value for association of 6.4 x 10(-33). Across these studies, fasting glucose concentrations increased 0.01-0.16 mM with each copy of the major allele, accounting for approximately 1% of the total variation in fasting glucose. The rs563694 SNP is located between the genes glucose-6-phosphatase catalytic subunit 2 (G6PC2) and ATP-binding cassette, subfamily B (MDR/TAP), member 11 (ABCB11). Our results in combination with data reported in the literature suggest that G6PC2, a glucose-6-phosphatase almost exclusively expressed in pancreatic islet cells, may underlie variation in fasting glucose, though it is possible that ABCB11, which is expressed primarily in liver, may also contribute to such variation. [ABSTRACT FROM AUTHOR]

Published
2008
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