1. Urinary phenethylamine response to d-amphetamine in 12 boys with attention deficit disorder.
- Author
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Zametkin AJ, Brown GL, Karoum F, Rapoport JL, Langer DH, Chuang LW, and Wyatt RJ
- Subjects
- Attention Deficit Disorder with Hyperactivity psychology, Attention Deficit Disorder with Hyperactivity urine, Child, Clinical Trials as Topic, Creatinine urine, Dextroamphetamine pharmacology, Dextroamphetamine urine, Double-Blind Method, Humans, Male, Motor Activity, Phenylacetates urine, Placebos, Attention Deficit Disorder with Hyperactivity drug therapy, Dextroamphetamine therapeutic use, Phenethylamines urine
- Abstract
Urinary phenethylamine (PEA), an endogenous amine similar to amphetamine in both molecular structure and pharmacological properties, was studied in 12 boys with attention deficit disorder with hyperactivity. d-Amphetamine and placebo were given for 14 days each in a counterbalanced crossover design; double-blind teacher behavior ratings and motor activity measurements were also obtained. Excretion of PEA, phenylacetic acid, creatinine, and d-amphetamine were measured. PEA was significantly increased and phenylacetic acid was unchanged after d-amphetamine administration, and change in PEA excretion correlated significantly with d-amphetamine excretion. There was no significant relationship between either clinical response to drug and change in PEA or phenylacetic acid excretion.
- Published
- 1984
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