1. Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
- Author
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Spielmann, Nadine, Leon, Arthur S., Rao, D.C., Rice, Treva, Skinner, James S., Rankinen, Tuomo, and Bouchard, Claude
- Subjects
Exercise -- Health aspects ,Exercise -- Research ,Heart beat -- Genetic aspects ,Heart beat -- Measurement ,Heart beat -- Research ,Human genome -- Research ,Biological sciences - Abstract
The purpose of this study was to identify regions of the human genome linked to submaximal exercise heart rates in the sedentary state and in response to a standardized 20-wk endurance training program in blacks and whites of the HERITAGE Family Study. A total of 701 polymorphic markers covering the 22 autosomes were used in the genome-wide linkage scan, with 328 sibling pairs from 99 white nuclear families and 102 pairs from 115 black family units. Steady-state heart rates were measured at the relative intensity of 60% maximal oxygen uptake (HR60) and at the absolute intensity of 50 W (HR50). Baseline phenotypes were adjusted for age, sex, and baseline body mass index (BMI) and training responses (posttraining minus baseline, [DELTA]) were adjusted for age, sex, baseline BMI, and baseline value of the phenotype. Two analytic strategies were used, a multipoint variance components and a regression-based multipoint linkage analysis. In whites, promising linkages (LOD > 1.75) were identified on 18q21-q22 for baseline HR50 (LOD = 2.64; P = 0.0002) and [DELTA]HR60 (LOD = 2.10; P = 0.0009) and on chromosome 2q33.3 for [DELTA]HR50 (LOD = 2.13; P = 0.0009). In blacks, evidence of promising linkage for baseline HR50 was detected with several markers within the chromosomal region 10q24-q25.3 (peak LOD = 2.43, P = 0.0004 with D10S597). The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and [DELTA]HR60 in whites. exercise training; linkage; quantitative trait loci; genotype
- Published
- 2007