1. On the origin of sustained negative BOLD response.
- Author
-
Moraschi M, DiNuzzo M, and Giove F
- Subjects
- Animals, Brain blood supply, Cerebrovascular Circulation physiology, Humans, Neurons physiology, Oxygen Consumption physiology, Primates, Brain physiology, Magnetic Resonance Imaging, Oxygen blood
- Abstract
Several brain regions exhibit a sustained negative BOLD response (NBR) during specific tasks, as assessed with functional magnetic resonance imaging. The origin of the NBR and the relationships between the vascular/metabolic dynamics and the underlying neural activity are highly debated. Converging evidence indicates that NBR, in human and non-human primates, can be interpreted in terms of decrease in neuronal activity under its basal level, rather than a purely vascular phenomenon. However, the scarcity of direct experimental evidence suggests caution and encourages the ongoing utilization of multimodal approaches in the investigation of this effect.
- Published
- 2012
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