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Start Over Author "Kirton, Adam" Publisher american physiological society
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2. Role of maxi-K+ channels in endothelin-induced vasoconstriction of mesenteric and submucosal arterioles

Author

Hill, Ceredwyn E., Kirton, Adam, Wu, Douglas D., and Vanner, Stephen J.

Subjects
Vasoconstriction -- Research, Endothelin -- Physiological aspects, Intestine, Small -- Physiological aspects, Smooth muscle -- Physiological aspects, Potassium channels -- Physiological aspects, Guinea pigs -- Physiological aspects, Biological sciences
Abstract

The mechanisms of action of endothelin and the maxi-potassium+ (maxi-K+) channels in the vasoconstriction of mesenteric and submucosal arteriole smooth muscle cells of the small intestine were investigated. Male albino guinea pigs were used as experimental models to determine the function of endothelin in resistance arterioles by measuring vasomotor activity in the vessels and monitoring membrane electrical properties in acutely dissociated smooth muscle cells. Results showed that opening maxi-K+ channels attenuated the impact of contraction induced by endothelin-1.

Published
1997

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