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Start Over Author "Fisher, David J." Publisher american physiological society
7 results on '"Fisher, David J."'

1. Regulation of SERCA 2 expression by thyroid hormone in cultured chick embryo cardiomycetes

Author

Fisher, David J., Phillips, Sharon, and McQuinn, Tim

Subjects
Thyroid hormones -- Physiological aspects, Heart cells -- Physiological aspects, Sarcoplasmic reticulum -- Physiological aspects, Biological sciences
Abstract

The role of the thyroid hormone in the regulation of sarcoplasmic reticulum (SR) calcium-adenosinetriphosphatase (Ca-ATPase) mRNA expression in the cardiomyocyte was investigated in the midterm chick embryo heart. SR Ca2+-ATPase mRNA measurements for cardiomycetes cultured in triiodothyronine (T3) were higher than control. However, T3 had no effect on Ca2+-ATPase mRNA in the thyroid hormone receptor-negative CV-1 cells. Results suggest that T3 increases the expression of SR Ca2+ pump, but the effect is localized to heart cells.

Published
1996

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