1. Race, Breast Cancer Subtypes, and Survival in the Carolina Breast Cancer Study
- Author
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Sharon N. Edmiston, Joseph Geradts, Chiu Kit Tse, Lisa A. Carey, Patricia G. Moorman, Sandra L. Deming, Lynn G. Dressler, H. Shelton Earp, Kathleen Conway, Chad A. Livasy, Robert C. Millikan, Torsten O. Nielsen, Maggie C.U. Cheang, David Cowan, Gamze Karaca, Melissa A. Troester, and Charles M. Perou
- Subjects
Adult ,Oncology ,medicine.medical_specialty ,Mitotic index ,Receptor, ErbB-2 ,Mammary gland ,Population ,Breast Neoplasms ,Breast cancer ,Internal medicine ,medicine ,Humans ,skin and connective tissue diseases ,education ,Aged ,Gynecology ,education.field_of_study ,Basal-like carcinoma ,business.industry ,Keratin-6 ,General Medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Black or African American ,ErbB Receptors ,medicine.anatomical_structure ,Receptors, Estrogen ,Basal-Like Breast Carcinoma ,Keratin-5 ,Keratins ,Female ,Triple-Negative Breast Carcinoma ,Menopause ,Receptors, Progesterone ,business - Abstract
Context: Gene expression analysis has identified several breast cancer subtypes, including basal-like, human epidermal growth factor receptor-2 positive/estrogen receptor negative (HER2+/ER–), luminal A, and luminal B. Objectives: To determine population-based distributions and clinical associations for breast cancer subtypes. Design, Setting, and Participants: Immunohistochemical surrogates for each subtype were applied to 496 incident cases of invasive breast cancer from the Carolina Breast Cancer Study (ascertained between May 1993 and December 1996), a population based, case-control study that oversampled premenopausal and African American women. Subtype definitions were as follows: luminal A (ER+ and/or progesterone receptor positive [PR+], HER2−), luminal B (ER+ and/or PR+, HER2+), basal-like (ER−, PR−, HER2−, cytokeratin 5/6 positive, and/or HER1+), HER2+/ER− (ER−, PR−, and HER2+), and unclassified (negative for all 5 markers). Main Outcome Measures: We examined the prevalence of breast cancer subtypes within racial and menopausal subsets and determined their associations with tumor size, axillary nodal status, mitotic index, nuclear pleomorphism, combined grade, p53 mutation status, and breast cancer–specific survival. Results The basal-like breast cancer subtype was more prevalent among premenopausal African American women (39%) compared with postmenopausal African American women (14%) and non–African American women (16%) of any age (P
- Published
- 2006