1. A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage
- Author
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Issam A. Awad, Yunke Li, Guido J. Falcone, Wendy C. Ziai, Daniel F. Hanley, Cenai Zhang, Tatiana Greige, Kevin N. Sheth, Pitchaiah Mandava, Babak B. Navi, Casey Norton, Ajay Gupta, Magdy Selim, Daniel Woo, Hooman Kamel, Vasileios-Arsenios Lioutas, Joshua N. Goldstein, Costantino Iadecola, Sung Min Cho, Alessandro Biffi, Jonathan Rosand, Santosh B. Murthy, Adnan I Qureshi, Chelsea S. Kidwell, Ashkan Shoamanesh, Radhika Avadhani, and Joshua J. Gruber
- Subjects
Male ,medicine.medical_specialty ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Hematoma ,Fibrinolytic Agents ,Humans ,Minimally Invasive Surgical Procedures ,Medicine ,Prospective Studies ,cardiovascular diseases ,030212 general & internal medicine ,Prospective cohort study ,Original Investigation ,Aged ,Cerebral Hemorrhage ,Randomized Controlled Trials as Topic ,Intracerebral hemorrhage ,medicine.diagnostic_test ,business.industry ,Leukoaraiosis ,Magnetic resonance imaging ,Odds ratio ,Middle Aged ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,Tissue Plasminogen Activator ,Acute Disease ,Etiology ,Female ,Neurology (clinical) ,Radiology ,business ,030217 neurology & neurosurgery ,Cohort study - Abstract
Importance The etiology and significance of diffusion-weighted imaging (DWI) lesions in patients with acute intracerebral hemorrhage (ICH) remain unclear. Objective To evaluate which factors are associated with DWI lesions, whether associated factors differ by ICH location, and whether DWI lesions are associated with functional outcomes. Design, Setting, and Participants This analysis pooled individual patient data from 3 randomized clinical trials (Minimally Invasive Surgery Plus Alteplase for Intracerebral Hemorrhage Evacuation phase 3 trial, Antihypertensive Treatment of Acute Cerebral Hemorrhage trial, and Intracerebral Hemorrhage Deferoxamine phase 2 trial) and 1 multicenter prospective study (Ethnic/Racial Variations of Intracerebral Hemorrhage). Patients were enrolled from August 1, 2010, to September 30, 2018. Of the 4782 patients, 1788 who underwent magnetic resonance imaging scans of the brain were included. Data were analyzed from July 1 to December 31, 2019. Main Outcomes and Measures The primary outcome consisted of factors associated with DWI lesions. Secondary outcomes were poor functional outcome, defined as a modified Rankin score (mRS) of 4 to 6, and mortality, both assessed at 3 months. Mixed-effects logistic regression was used to evaluate the association between exposures and outcomes. Subgroup analyses stratified by hematoma location were performed. Results After exclusion of 36 patients with missing data on DWI lesions, 1752 patients were included in the analysis (1019 men [58.2%]; mean [SD] age, 60.8 [13.3] years). Diffusion-weighted imaging lesions occurred in 549 patients (31.3%). In mixed-effects regression models, factors associated with DWI lesions included younger age (odds ratio [OR] per year, 0.98; 95% CI, 0.97-0.99), black race (OR, 1.64; 95% CI, 1.17-2.30), admission systolic blood pressure (OR per 10–mm Hg increase, 1.13; 95% CI, 1.08-1.18), baseline hematoma volume (OR per 10-mL increase, 1.12; 95% CI, 1.02-1.22), cerebral microbleeds (OR, 1.85; 95% CI, 1.39-2.46), and leukoaraiosis (OR, 1.59; 95% CI, 1.67-2.17). Diffusion-weighted imaging lesions were independently associated with poor mRS (OR, 1.50; 95% CI, 1.13-2.00), but not with mortality (OR, 1.11; 95% CI, 0.72-1.71). In subgroup analyses, similar factors were associated with DWI lesions in lobar and deep ICH. Diffusion-weighted imaging lesions were associated with poor mRS in deep but not lobar ICH. Conclusions and Relevance In a large, heterogeneous cohort of prospectively identified patients with ICH, results were consistent with the hypothesis that DWI lesions represent acute sequelae of chronic cerebral small vessel disease, particularly hypertensive vasculopathy. Diffusion-weighted imaging lesions portend a worse prognosis after ICH, mainly deep hemorrhages.
- Published
- 2020