1. Regression of Carotid and Femoral Artery Intima-Media Thickness in Familial Hypercholesterolemia
- Author
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Rudolf J.A Buirma, John J.P. Kastelein, Aeilko H. Zwinderman, Pernette R. W. de Sauvage Nolting, Mieke D. Trip, Eric de Groot, Vascular Medicine, Epidemiology and Data Science, Cardiology, and Amsterdam Cardiovascular Sciences
- Subjects
Adult ,Male ,Tunica media ,Simvastatin ,medicine.medical_specialty ,Statin ,medicine.drug_class ,Femoral artery ,Familial hypercholesterolemia ,Drug Administration Schedule ,Hyperlipoproteinemia Type II ,Internal medicine ,medicine.artery ,Internal Medicine ,medicine ,Humans ,cardiovascular diseases ,Aged ,Ultrasonography ,Vascular disease ,business.industry ,Anticholesteremic Agents ,Middle Aged ,medicine.disease ,Tunica intima ,Lipids ,Surgery ,Femoral Artery ,Carotid Arteries ,Treatment Outcome ,medicine.anatomical_structure ,Intima-media thickness ,Cardiovascular Diseases ,cardiovascular system ,Cardiology ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,Tunica Intima ,Tunica Media ,business ,medicine.drug - Abstract
Objective: To investigate whether high-dose simvastatin therapy could reduce carotid and femoral artery intima-media thickness (IMT) in patients with familial hypercholesterolemia (FH) to prevent cardiovascular disease. Background: Imaging of arterial walls with B-mode ultrasonography is increasingly used as a noninvasive surrogate marker of cardiovascular disease. Intervention trials using this modality have shown that by reducing risk factors, progression of atherosclerosis was inhibited. Methods: After a washout period of 6 weeks, all patients with FH started monotherapy with sinivastatin, 80 mg/d, for 2 years. The primary end point was the change (in millimeters) of the mean combined far-wall IMT of predefined carotid and femoral arterial segments at 2 years. Results: We included a total of 153 patients with FH. Mean +/- SD combined baseline IMT was 1.07 +/- 0.23 mm. After treatment with sinivastatin for 2 years, this IMT decreased by a mean of 0.081 mm (95% confidence interval, -0.109 to -0.053; P
- Published
- 2003
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