1. Screening for Cell-Mediated Immunity in Children
- Author
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Alberto G. Ugazio, G. Roberto Burgio, and Francesca Severi
- Subjects
Adult ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Early detection ,Lymphocyte Activation ,Immune system ,Lectins ,medicine ,Humans ,Child ,Immunodeficiency ,Aged ,Skin Tests ,Immunity, Cellular ,Skin reactivity ,business.industry ,Immunologic Deficiency Syndromes ,Infant, Newborn ,Infant ,Middle Aged ,medicine.disease ,Cell mediated immunity ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,business - Abstract
Sir .—The article by Dr Steele and colleagues ( Am J Dis Child 130:1218,1976) rightly underlines the need for reliable and simple tests of cellular immune competence to permit early detection of immunodeficiency diseases in infancy and childhood. In a series of 608 individuals, ranging in age from newborn to more than 70 years, whose skin was tested with phytohemagglutinin (PHA), we previously reported 1,2 an overall positivity of 98%; the only negative subjects were ten of 32 newborns. On the other In a series of 608 individuals, ranging in age from newborn to more than 70 years, whose skin was tested with phytohemagglutinin (PHA), we previously reported 1,2 an overall positivity of 98%; the only negative subjects were ten of 32 newborns. On the other hand, skin reactivity to streptokinase assessed in 584 individuals (age range, birth to more than 70 years) was remarkably age-depen dent. Some of these data (concerning subjects of
- Published
- 1977
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