1. Hyperlipidemia due to oxymetholone therapy. Occurrence in a long-term hemodialysis patient.
- Author
-
Reeves RD, Morris MD, and Barbour GL
- Subjects
- Acute Kidney Injury therapy, Humans, Hypercholesterolemia chemically induced, Lipoproteins blood, Lipoproteins, VLDL blood, Male, Middle Aged, Oxymetholone administration & dosage, Time Factors, Triglycerides blood, Hyperlipidemias chemically induced, Oxymetholone adverse effects, Renal Dialysis
- Abstract
Marked hypertriglyceridemia and hypercholesterolemia accompanied by angina and a left cerebral thrombosis occurred in a long-term hemodialysis patient following 5 1/2 weeks of oral treatment with oxymetholone, 100 mg/day, a synthetic androgen. After androgen therapy was discontinued, over a three-month period, plasma lipid values progressively decreased below pretreatment values, and clinical symptoms disappeared. During rechallenge with oxymetholone, serum lipid values increased substantially, and the lipoprotein pattern changed from a type IV to a type V. Detailed lipid studies showed subnormal postheparin lipolytic activity and a fast-migrating pre-beta-lipoprotein in a very-low-density lipoproteins (VLDL) fraction. Because of the data linking lipid abnormalities to atherosclerosis and the acceleration of atherosclerosis in long-term hemodialysis patients, great caution should be exercised in administering androgenic steroids to these patients.
- Published
- 1976