5 results on '"Mead PS"'
Search Results
2. Antimicrobial therapy in patients with Escherichia coli O157:H7 infection.
- Author
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Mølbak K, Mead PS, Griffin PM, Mølbak, Kåre, Mead, Paul S, and Griffin, Patricia M
- Published
- 2002
- Full Text
- View/download PDF
3. Lyme disease -- United States, 2003-2005.
- Author
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Bacon RM, Kugeler KJ, Griffith KS, and Mead PS
- Published
- 2007
- Full Text
- View/download PDF
4. An outbreak of Escherichia coli O157 infection following exposure to a contaminated building.
- Author
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Varma JK, Greene KD, Reller ME, DeLong SM, Trottier J, Nowicki SF, DiOrio M, Koch EM, Bannerman TL, York ST, Lambert-Fair MA, Wells JG, and Mead PS
- Subjects
- Adolescent, Adult, Case-Control Studies, Child, Child, Preschool, Diarrhea epidemiology, Diarrhea microbiology, Escherichia coli Infections etiology, Female, Hemolytic-Uremic Syndrome epidemiology, Hemolytic-Uremic Syndrome etiology, Humans, Infant, Male, Middle Aged, Ohio epidemiology, Risk Factors, Air Pollution, Indoor adverse effects, Air Pollution, Indoor analysis, Disease Outbreaks, Environmental Exposure adverse effects, Environmental Exposure analysis, Escherichia coli Infections epidemiology, Escherichia coli O157 isolation & purification
- Abstract
Context: Infection with Escherichia coli O157 causes an estimated 70 000 diarrheal illnesses per year in the United States and can result in hemolytic-uremic syndrome and death. Environmental contamination with E coli O157 may be a public health problem., Objectives: To determine risk factors for E coli O157 infection during an outbreak investigation at a county fair and to evaluate environmental contamination as a possible cause of the outbreak., Design, Setting, and Participants: Case-control study of 23 patients (median age, 15 years) and 53 age-matched controls who had attended the Lorain County, Ohio, fair between August 20 and August 26, 2001. Case-patients had laboratory-confirmed E coli O157 infection, hemolytic-uremic syndrome, or bloody diarrhea within 7 days of attending the fair; controls attended the fair and did not have diarrhea., Main Outcome Measures: Risk factors for infection and isolates of E coli O157 from environmental specimens., Results: Six (26%) case-patients were hospitalized and 2 (9%) developed hemolytic-uremic syndrome. Case-patients were more likely than controls to have visited building A (a multipurpose community facility on the fairgrounds; matched odds ratio [MOR], 21.4 [95% confidence interval [CI], 2.7-170.7]). Among visitors to building A, illness was independently associated with attending a dance in the building (MOR, 7.5; 95% CI, 1.4-41.2), handling sawdust from the floor (MOR, 4.6; 95% CI, 1.1-20.0), or eating and/or drinking in the building (MOR, 4.5; 95% CI, 1.2-16.6). Twenty-four (44%) of 54 specimens collected from building A 6 weeks after the fair grew Shiga toxin-producing E coli O157. Isolates from sawdust, the rafters, and other surfaces were identical by molecular fingerprinting to patient isolates. Sawdust specimens collected 42 weeks after the fair also grew the same E coli O157 strain., Conclusions: Absence of evidence implicating specific food or beverage sources and the recovery of E coli O157 from the rafters suggest that airborne dispersion of bacteria contributed to the contamination. Because E coli O157 can survive in the environment for more than 10 months, humans may be at risk of infection long after an environment is initially contaminated.
- Published
- 2003
- Full Text
- View/download PDF
5. Investigation of multidrug-resistant Salmonella serotype typhimurium DT104 infections linked to raw-milk cheese in Washington State.
- Author
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Villar RG, Macek MD, Simons S, Hayes PS, Goldoft MJ, Lewis JH, Rowan LL, Hursh D, Patnode M, and Mead PS
- Subjects
- Adolescent, Adult, Ampicillin Resistance, Animals, Case-Control Studies, Cheese poisoning, Child, Child, Preschool, Chloramphenicol Resistance, Electrophoresis, Gel, Pulsed-Field, Epidemiologic Methods, Food Handling, Hispanic or Latino, Humans, Infant, Middle Aged, Milk poisoning, Risk Factors, Salmonella Food Poisoning etiology, Serotyping, Sterilization, Streptomycin pharmacology, Sulfonamides pharmacology, Tetracycline Resistance, Washington epidemiology, Cheese microbiology, Disease Outbreaks, Drug Resistance, Microbial, Drug Resistance, Multiple, Milk microbiology, Salmonella Food Poisoning epidemiology, Salmonella typhimurium classification, Salmonella typhimurium drug effects, Salmonella typhimurium isolation & purification
- Abstract
Context: Multidrug-resistant Salmonella Typhimurium DT104 has recently emerged as a cause of human and animal illness in Europe and North America. In early 1997, health officials in Yakima County, Washington, noted a 5-fold increase in salmonellosis among the county's Hispanic population., Objectives: To characterize bacterial strains and identify risk factors for infection with Salmonella Typhimurium in Yakima County., Design: Laboratory, case-control, and environmental investigations., Setting and Participants: Patients with culture-confirmed Salmonella Typhimurium infection living in Yakima County and age- and neighborhood-matched control subjects., Main Outcome Measures: Food vehicle implication based on case-control study and outbreak control., Results: Between January 1 and May 5, 1997, 54 culture-confirmed cases of Salmonella Typhimurium were reported. The median age of patients was 4 years and 91% were Hispanic. Patients reported diarrhea (100%), abdominal cramps (93%), fever (93%), bloody stools (72%), and vomiting (53%); 5 patients (9%) were hospitalized. Twenty-two patients and 61 control subjects were enrolled in the case-control study. Seventeen case patients (77%) reported eating unpasteurized Mexican-style soft cheese in the 7 days before onset of illness compared with 17 control subjects (28%) (matched odds ratio, 32.3; 95% confidence interval, 3.0-874.6). All case-patient isolates were phage definitive type 104 (DT104) (n = 10) or DT104b (n = 12), and 20 (91%) were resistant to ampicillin, chloramphenicol, streptomycin, sulfamethoxazole, and tetracycline. The cheese produced and eaten by 2 unrelated patients was made with raw milk traced to the same local farm. Milk samples from nearby dairies yielded Salmonella Typhimurium DT104. The incidence of Salmonella Typhimurium infections in Yakima County returned to pre-1992 levels following interventions based on these findings., Conclusions: Multidrug-resistant Salmonella Typhimurium DT104 emerged as a cause of salmonellosis in Yakima County, and Mexican-style soft cheese made with unpasteurized milk is an important vehicle for Salmonella Typhimurium DT104 transmission. We postulate that recent increases in human salmonellosis reflect the emergence of Salmonella Typhimurium DT104 among dairy cows in the region. Continued efforts are needed to discourage consumption of raw milk products, promote healthier alternatives, and study the ecology of multidrug-resistant Salmonella Typhimurium.
- Published
- 1999
- Full Text
- View/download PDF
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