1. Association of Myocardial Fibrosis and Stroke Volume by Cardiovascular Magnetic Resonance in Patients With Severe Aortic Stenosis With Outcome After Valve Replacement: The British Society of Cardiovascular Magnetic Resonance AS700 Study
- Author
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George D. Thornton, Tarique A. Musa, Marzia Rigolli, Margaret Loudon, Calvin Chin, Silvia Pica, Tamir Malley, James R. J. Foley, Vassilios S. Vassiliou, Rhodri H. Davies, Gabriella Captur, Laura E. Dobson, James C. Moon, Marc R. Dweck, Saul G. Myerson, Sanjay K. Prasad, John P. Greenwood, Gerry P. McCann, Anvesha Singh, and Thomas A. Treibel
- Subjects
Aged, 80 and over ,Male ,Magnetic Resonance Spectroscopy ,Contrast Media ,Gadolinium ,Stroke Volume ,Aortic Valve Stenosis ,Fibrosis ,Ventricular Function, Left ,Cohort Studies ,Cicatrix ,Humans ,Female ,Longitudinal Studies ,Cardiology and Cardiovascular Medicine ,Original Investigation ,Aged - Abstract
IMPORTANCE: Low-flow severe aortic stenosis (AS) has higher mortality than severe AS with normal flow. The conventional definition of low-flow AS is an indexed stroke volume (SVi) by echocardiography less than 35 mL/m(2). Cardiovascular magnetic resonance (CMR) is the reference standard for quantifying left ventricular volumes and function from which SVi by CMR can be derived. OBJECTIVE: To determine the association of left ventricular SVi by CMR with myocardial remodeling and survival among patients with severe AS after valve replacement. DESIGN, SETTING, AND PARTICIPANTS: This multicenter longitudinal cohort study was conducted between January 2003 and May 2015 across 6 UK cardiothoracic centers. Patients with severe AS listed for either surgical aortic valve replacement (SAVR) or transcatheter aortic valve replacement (TAVR) were included. Patients underwent preprocedural echocardiography and CMR. Patients were stratified by echocardiography-derived aortic valve mean and/or peak gradient and SVi by CMR into 4 AS endotypes: low-flow, low-gradient AS; low-flow, high-gradient AS; normal-flow, low-gradient AS; and normal-flow, high-gradient AS. Patients were observed for a median of 3.6 years. Data were analyzed from September to November 2021. EXPOSURES: SAVR or TAVR. MAIN OUTCOMES AND MEASURES: All-cause and cardiovascular (CV) mortality after aortic valve intervention. RESULTS: Of 674 included patients, 425 (63.1%) were male, and the median (IQR) age was 75 (66-80) years. The median (IQR) aortic valve area index was 0.4 (0.3-0.4) cm(2)/m(2). Patients with low-flow AS endotypes (low gradient and high gradient) had lower left ventricular ejection fraction, mass, and wall thickness and increased all-cause and CV mortality than patients with normal-flow AS (all-cause mortality: hazard ratio [HR], 2.08; 95% CI, 1.37-3.14; P
- Published
- 2022