1. Association of COVID-19 Acute Respiratory Distress Syndrome With Symptoms of Posttraumatic Stress Disorder in Family Members After ICU Discharge
- Author
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Azoulay, Elie, Resche-Rigon, Matthieu, Megarbane, Bruno, Reuter, Danielle, Labbé, Vincent, Cariou, Alain, Géri, Guillaume, van Der Meersch, Guillaume, Kouatchet, Achille, Guisset, Olivier, Bruneel, Fabrice, Reignier, Jean, Souppart, Virginie, Barbier, François, Argaud, Laurent, Quenot, Jean-Pierre, Papazian, Laurent, Guidet, Bertrand, Thiéry, Guillaume, Klouche, Kada, Lesieur, Olivier, Demoule, Alexandre, Guitton, Christophe, Capellier, Gilles, Mourvillier, Bruno, Biard, Lucie, Pochard, Frédéric, Kentish-Barnes, Nancy, Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Lariboisière-Fernand-Widal [APHP], Centre Hospitalier Sud Francilien [Corbeil-Essonnes] (CH Sud Francilien), CHU Tenon [AP-HP], Hôpital Cochin [AP-HP], Hôpital Ambroise Paré [AP-HP], Hôpital Avicenne [AP-HP], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hôpital Saint-André, Centre Hospitalier de Versailles André Mignot (CHV), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre Hospitalier Régional d'Orléans (CHRO), Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Hôpital Nord [CHU - APHM], CHU Saint-Antoine [AP-HP], Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Hôpital Lapeyronie [Montpellier] (CHU), Groupe hospitalier de La Rochelle, CHU Pitié-Salpêtrière [AP-HP], Neurophysiologie Respiratoire Expérimentale et Clinique (UMRS 1158), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), and Centre Hospitalier Universitaire de Reims (CHU Reims)
- Subjects
[SDV]Life Sciences [q-bio] ,General Medicine ,Original Investigation - Abstract
IMPORTANCE: Persistent physical and mental disorders are frequent in survivors of COVID-19–related acute respiratory distress syndrome (ARDS). However, data on these disorders among family members are scarce. OBJECTIVE: To determine the association between patient hospitalization for COVID-19 ARDS vs ARDS from other causes and the risk of posttraumatic stress disorder (PTSD)–related symptoms in family members. DESIGN, SETTING, AND PARTICIPANTS: Prospective cohort study in 23 intensive care units (ICUs) in France (January 2020 to June 2020 with final follow-up ending in October 2020). ARDS survivors and family members (1 family member per patient) were enrolled. EXPOSURES: Family members of patients hospitalized for ARDS due to COVID-19 vs ARDS due to other causes. MAIN OUTCOMES AND MEASURES: The primary outcome was family member symptoms of PTSD at 90 days after ICU discharge, measured by the Impact of Events Scale-Revised (score range, 0 [best] to 88 [worst]; presence of PTSD symptoms defined by score >22). Secondary outcomes were family member symptoms of anxiety and depression at 90 days assessed by the Hospital Anxiety and Depression Scale (score range, 0 [best] to 42 [worst]; presence of anxiety or depression symptoms defined by subscale scores ≥7). Multivariable logistic regression models were used to determine the association between COVID-19 status and outcomes. RESULTS: Among 602 family members and 307 patients prospectively enrolled, 517 (86%) family members (median [IQR] age, 51 [40-63] years; 72% women; 48% spouses; 26% bereaved because of the study patient’s death; 303 [50%] family members of COVID-19 patients) and 273 (89%) patients (median [IQR] age, 61 [50-69] years; 34% women; 181 [59%] with COVID-19) completed the day-90 assessment. Compared with non–COVID-19 ARDS, family members of patients with COVID-19 ARDS had a significantly higher prevalence of symptoms of PTSD (35% [103/293] vs 19% [40/211]; difference, 16% [95% CI, 8%-24%]; P
- Published
- 2022