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9 results on '"Grassi, MA"'

4. Night Blindness, Ring Scotoma, and a Nonrecordable Electroretinogram in an Elderly Woman.

Author

Grassi MA, Maker MP, and Marmor MF

Subjects
Aged, Antirheumatic Agents administration & dosage, Electroretinography, Female, Humans, Hydroxychloroquine administration & dosage, Night Blindness chemically induced, Night Blindness physiopathology, Retina physiopathology, Retinal Diseases chemically induced, Retinal Diseases physiopathology, Scotoma chemically induced, Scotoma physiopathology, Tomography, Optical Coherence, Visual Acuity, Visual Field Tests, Visual Fields physiology, Antirheumatic Agents adverse effects, Hydroxychloroquine adverse effects, Night Blindness diagnosis, Retina drug effects, Retinal Diseases diagnosis, Scotoma diagnosis
Published
2019
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5. Vision Loss in a Teenage Girl With Postconcussion Syndrome.

Author

Al-Khersan H, Hain T, and Grassi MA

Subjects
Adolescent, Ataxin-7 genetics, Electroretinography, Female, Genetic Counseling, Genetic Testing, Humans, Spinocerebellar Ataxias genetics, Tomography, Optical Coherence, Vision Disorders physiopathology, Visual Acuity, Visual Field Tests, Post-Concussion Syndrome diagnosis, Spinocerebellar Ataxias diagnosis, Vision Disorders diagnosis
Abstract

Competing Interests: Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Published
2017
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6. Cobalamin C Deficiency-Associated Pigmentary Retinopathy.

Author

Garcia-Gonzalez JM, Neiweem AE, and Grassi MA

Subjects
Carrier Proteins genetics, Child, Electroretinography, Female, Homocystinuria genetics, Humans, Mutation, Oxidoreductases, Retinitis Pigmentosa genetics, Vitamin B 12 Deficiency diagnosis, Vitamin B 12 Deficiency genetics, Homocystinuria diagnosis, Retinitis Pigmentosa diagnosis, Vitamin B 12 Deficiency congenital
Abstract

Competing Interests: Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.

Published
2015
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7. Toxoplasmosis-associated neovascular lesions treated successfully with ranibizumab and antiparasitic therapy.

Author

Benevento JD, Jager RD, Noble AG, Latkany P, Mieler WF, Sautter M, Meyers S, Mets M, Grassi MA, Rabiah P, Boyer K, Swisher C, and McLeod R

Subjects
Adult, Antibodies, Monoclonal, Humanized, Child, Choroidal Neovascularization diagnosis, Choroidal Neovascularization parasitology, Drug Therapy, Combination, Fluorescein Angiography, Humans, Injections, Leucovorin therapeutic use, Male, Pyrimethamine therapeutic use, Ranibizumab, Retinal Hemorrhage diagnosis, Retinal Hemorrhage parasitology, Sulfadiazine therapeutic use, Tomography, Optical Coherence, Toxoplasmosis, Ocular diagnosis, Toxoplasmosis, Ocular parasitology, Visual Acuity, Vitreous Body, Antibodies, Monoclonal therapeutic use, Antiprotozoal Agents therapeutic use, Choroidal Neovascularization drug therapy, Retinal Hemorrhage drug therapy, Toxoplasmosis, Ocular drug therapy
Published
2008
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8. Complement factor H polymorphism p.Tyr402His and cuticular Drusen.

Author

Grassi MA, Folk JC, Scheetz TE, Taylor CM, Sheffield VC, and Stone EM

Subjects
Adult, Aged, Aged, 80 and over, Complement Factor H genetics, Female, Genotype, Humans, Macular Degeneration genetics, Male, Middle Aged, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Retinal Drusen genetics
Abstract

Objective: To determine the histidine frequency in patients with the cuticular drusen phenotype of age-related macular degeneration (AMD)., Methods: Fifty individuals were identified who met the criteria for the cuticular drusen phenotype using a standard threshold photograph. We genotyped DNA samples using a polymerase chain reaction-based restriction digest assay. Seven hundred individuals with typical AMD and 252 controls were also genotyped. Fisher exact test was used to analyze the significance of allele frequency differences., Results: The histidine variant was present in 70% (frequency +/- SE, 0.70 +/- 0.05) of the cuticular cohort, 55% (frequency +/- SE, 0.55 +/- 0.01) of the more typical AMD cases, and 34% (frequency +/- SE, 0.34 +/- 0.02) of controls. The association between the cuticular drusen phenotype and the histidine allele was highly significant (P = .003; odds ratio, 2.0; 95% confidence interval, 1.21-3.07; vs AMD cases P<.001; odds ratio 4.54; 95% confidence interval, 2.79-7.50; vs controls). Genotype distribution between the 3 groups was similarly significant (P<.001)., Conclusion: The cuticular drusen phenotype is highly associated with the Tyr402His variant of the complement factor H (CFH) gene. The significantly higher histidine allele frequency in this group compared with the typical AMD cohort suggests that the complement cascade may play a greater role in the pathogenesis of the cuticular drusen subtype than in AMD as a whole., Clinical Relevance: The c.1204T>C, p.Tyr402His allelic variant in the CFH gene is associated with a 3-fold increased risk for AMD. A high frequency of the histidine allele has also been noted in patients with membranoproliferative glomerulonephritis type II.

Published
2007
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