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Background The association of cystatin C, a novel marker of renal function, with risk for developing complications related to peripheral arterial disease (PAD) has not been examined. Methods We evaluated the hypothesis that a high cystatin C concentration is independently associated with future PAD events among 4025 participants in the Cardiovascular Health Study who underwent serum cystatin C measurement at the 1992-1993 visit and who did not have PAD at baseline. The association of cystatin C quintiles with time to first lower-extremity PAD procedure (bypass surgery, angioplasty, or amputation) was evaluated using multivariable proportional hazards models. Secondary analyses were conducted using quintiles of serum creatinine level and estimated glomerular filtration rate (eGFR). Results The annualized risk of undergoing a procedure for PAD was 0.43% per year among participants in the highest cystatin C quintile (>1.27 mg/L) compared with 0.21% per year or less in all other quintiles. After multivariable adjustment for known risk factors for PAD, elevated cystatin C levels remained associated with the outcome (hazard ratio, 2.5 for highest vs lowest quintile of cystatin C, 95% confidence interval, 1.2-5.1). The highest quintiles of serum creatinine level and eGFR were not associated with future PAD events in either unadjusted or adjusted analyses. Conclusion Elevated concentrations of cystatin C were independently predictive of incident PAD events among community-dwelling elderly patients. [ABSTRACT FROM AUTHOR]

The article reports on the study that examines the slop of annual decline in estimated glomerular filtration rate (eGFR) using both serum creatinine and cystatin rates in the American older people. The study, conducted by Internal Medicine Dena E. Rifkin and colleagues, reveals that the association of rapid decline in eGFR with elevated mortality risk did not differ across subgroups based on baseline kidney function, age, sex, and prevalent coronary heart disease. It also suggests that rapid decline in eGFR is associated with an increased risk of cardiovascular and all-acute cause mortality in older adults.

The article discusses the effect of Cystatin C on successful aging. A study was conducted to determine the relation between kidney function and aging success for a six-year follow-upcardiovascular health study in the United States. The level of Cystatin C of the Two thousand one hundred forty participants have been observed. The result of the study showed that even if the patient possess a relatively normal kidney function, the presence of cystatin C in a higher level, the greater unsuccessful aging it entails.