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Background: Corn silk contains health promoting phytochemicals which could be applied in the treatment of cardiovascular diseases. Aim and objectives: This was designed to evaluate the effect of corn silk extract on lipid profile, CK-MB and LDH. Methods: Fifteen rabbits divided into three experimental groups of 5 rabbits each were studied. The control group(A) was not ingested with the extract throughout the period of study. Group B was ingested with the water extract for 3 weeks while group C was ingested with the mathanolic extract for 3 weeks. Plasma lipid profile, CK-MB and LDH were estimated in the rabbits biochemically by spectrophotometry. The rabbits were well kept and placed on normal diet throughout the period of study. Results: There was a significantly higher mean value of plasma Total Cholesterol Triglyceride in the control rabbits than those obtained in the test rabbits after one week of the administration of methanolic and aqueous extract of corn silk (p<0.05). There was a significantly lower mean value of plasma Total Cholesterol and Triglyceride in the control rabbits than those obtained in the test rabbits after two and three weeks of the administration of methanolic and aqueous extract of corn silk (p<0.05). There was a significantly lower mean value of plasma LDL- Cholesterol in the control rabbits than those obtained in the test rabbits after 2 and 3 weeks of the administration of methanolic and aqueous extract of corn silk (p<0.05). There was a significantly lower mean plasma CK-MB value in the test rabbits than the control rabbits after 3 weeks of administration of aqueous extract of corn silk (p<0.05). There was a significant decrease in Cholesterol and Triglyceride in the rabbits after one week of methanolic extract but prolong administration of the extract significantly increased the Cholesterol, Triglycerides and LDL-Cholesterol. The corn silk extract also has a lowering effect on CK-MB in rabbits administered with corn silk extract. Conclusion: Estimation of plasma CK-MB, Cholesterol, Triglyceride and LDL-Cholesterol in patient undergoing treatment with corn silk extract will be a useful indicies for effective management. [ABSTRACT FROM AUTHOR]