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The auditory compound action potential (CAP) represents synchronous VIIIth nerve activity. Clicks or impulses have been used in the past to produce this synchrony under the assumption that the wide spectral spread inherent in transient signals will activate a large portion of the cochlear partition. However, the observation that only auditory nerve units tuned above 3 kHz contribute to synchronous activity in the N1P1 complex of the CAP [Dolan et al., J. Acoust. Soc. Am. 73, 580-591 (1983)] suggests that temporal delays imposed by the traveling wave result in an asynchronous pattern of VIIIth nerve activation. In order to determine if units tuned below 3 kHz could be recruited into the CAP response, the present study uses tone bursts of exponentially rising frequency to hypothetically activate synchronous discharges of VIIIth nerve fibers along the length of the cochlear partition. The equations defining the frequency sweeps are calculated to be the inverse of the delay-line characteristics of the guinea pig cochlear partition. The resultant sweeps theoretically cause a constant phase displacement of a large portion of the cochlear partition at one time. Compound action potentials recorded in response to the rising frequency sweeps were compared to CAPs evoked by corresponding falling frequency sweeps and clicks. Analysis of the CAP waveforms showed narrower N1 widths and larger N1 and P1 amplitudes for rising sweeps when compared to falling sweeps. This is consistent with the hypothesis of increased synchrony. A further test of the hypothesis was made by using high-pass masking noise to evaluate the contributions of discrete cochlear locations to the CAP (''derived'' CAP). Latency functions of the derived CAPs for clicks and falling frequency sweeps showed progressive increases in latency as the cutoff frequency of the high-pass filter was lowered. The latency of the derived CAP for these stimulus conditions reflects traveling wave delays [Aran and Cazals, ''Electrocochleography: Animal studies,'' in Evoked Electrical Activity in The Auditory Nervous System (Academic, New York, 1978)]. In contrast, derived CAPs obtained from rising sweeps showed no change in latency for any cutoff frequencies, indicating a constant delay of response for fibers with different characteristic frequencies (CFs). These results support the theoretical premise underlying the derivation of the rising sweep: Spectral energy with the appropriate temporal organization, dictated by basilar membrane traveling wave properties, will increase CAP synchrony. [ABSTRACT FROM AUTHOR]

The effects of lowered cochlear temperature on eighth-nerve tuning were assessed by using forward masking of whole nerve action potential (AP) responses to generate AP tuning curves (APTCs) at cochlear temperatures ranging from 38.5° to 30 °C for probe frequencies from 8 to 36 kHz. The data indicate that subnormal cochlear temperatures result in: (a) broadened APTCs for probe frequencies above 10 kHz which are interpreted as resulting from reduced hair-cell frequency selectivity, (b) lowered or more sensitive APTC tips where tone-burst thresholds are unchanged, and (c) raised or less sensitive tips where thresholds to tone bursts were elevated. Increased tip sensitivity is explained in terms of enhanced eighth-nerve adaptation which occurred during hypothermia. Experiments directly addressing adaptation were performed, in which the masker-probe interval (Δt) was systematically lengthened. The normalized AP decrement versus Δt functions indicate an enhancement of both the amount and duration of adaptation during hypothermia. Functions relating the growth of response to the masker (AP decrement versus masker intensity functions) were reduced at low temperatures. [ABSTRACT FROM AUTHOR]

When responses to one part of a sequence of auditory signals reduce the responses to a subsequent portion of the signal, 'forward masking' results. Although forward masking occurs in the auditory nerve, that observed in the ventral cochlear nucleus (VCN) more closely resembles psychophysical forward masking. In contrast to the auditory nerve in which the amount of forward masking is proportional to the amount of excitation produced by the masker, most VCN neurons show a poor correlation between forward masking and excitation produced by the masker, indicating a more complex interaction between responses to adjacent signals. This study tested the hypothesis that one component of forward masking is produced by inputs from centrifugal neural connections to the VCN. The centrifugal pathways were interrupted with knife-cut lesions medial to the CN. Responses of single units obtained 60 minutes after the lesions were compared to those obtained before the lesions. In primarylike, sustained chopper and on units the lesions resulted in a reduction in forward masking and enhanced recovery. In contrast, lesions resulted in increased masking in primarylike-notch and low-intensity chopper units. The relationship between masker-elicited excitation and forward masking became more monotonic for transient choppers and on units, approaching that observed for auditory nerve fibers. These effects are probably the result of removal of both inhibitory and excitatory inputs, ultimately reflecting a balance of excitation and inhibition to each neural population in the VCN. © 1998 Acoustical Society of America. [ABSTRACT FROM AUTHOR]

This study examines the encoding of rapid frequency sweeps in single units of the ventral cochlear nucleus (VCN). Sweeps were designed to explore the role of cochlear mechanics in shaping the temporal responses across cells in the VCN. The time course of frequency change for rapidly rising frequency sweeps theoretically produced simultaneous displacement maxima by canceling travel time along the cochlear partition. Rising sweeps with longer time courses only partially canceled travel time, while falling sweeps had time courses of frequency change equal to or greater than travel time. Falling sweeps thus augmented normal travel time. Latency of unit firing to sweeps across unit characteristic frequency (CF) reflected cochlear delay-line mechanics. The latency-CF functions agreed with predictions from travel-time estimates for rising-frequency sweeps, but responses to falling sweeps were less predictable. [ABSTRACT FROM AUTHOR]

Cochlear microphonic recordings from 10 guinea pig cochleas were used to infer cochlear partition displacement patterns to frequency varying signals. Rate-dependent differences between rising and falling sweeps were predicted on the basis of delay-line characteristics of the cochlear partition. The frequency responses of three basal turn locations were assessed using puretones of different frequencies. Tone sweeps with different frequency change rates (i.e., frequency endpoints were kept constant and duration was varied) were generated near the 'best-frequencies' of these regions. Responses to sweeps obtained from each electrode location were summed and the time of occurrence of cochlear microphonic maxima and minima from each location was measured relative to the other locations. The results indicate that inferred cochlear partition displacements to falling frequency sweeps occur sequentially at different points along the partition. Corresponding rising-frequency sweeps cause displacements more closely spaced in time. Displacement pattern differences occurred only at high rates of change. At low rates, cochlear partition displacements for the rising sweep disperse in time, showing the sequential pattern obtained with falling sweeps. [Work supported by NIH.] [ABSTRACT FROM AUTHOR]