Search

Azole derivatives are valuable precursors in pharmacological arena. In fact, oxazole, thiazole and imidazole containing scaffolds display a variety of biological activities such as antitumor,1 antibacterial,2 antiviral,3 antioxidant,4,5 anti-inflammatory6 and antifungal7 activities. Azoles are also prominant molecules in various biochemical and synthetic transformations. Based on the importance of these heteroaromatics and also our interest to link the heterocycle molecules with a variety of functional groups we have synthesized a new class of bis(azolyl)sulfonamide acetamides from azolylsulfonylamines and azolylchloroacetamides in the presence of DMAP under ultrasonication and studied their antimicrobial activity. The compounds chloro substituted bis(thiazoles) (6c) and chloro substituted imidazolyl thiazoles (7c) displayed excellent antibacterial activity against B. subtilis greater than the standard drug, Chloramphenicol. Whereas 7c also showed excellent antifungal activity on A. niger higher than the standard drug, Ketoconazole. [ABSTRACT FROM AUTHOR]

Cyclic sulfonamides (sultams) gained importance due to their potential pharmaceutical activity. Amongst these, 1,2-benzothiazine-1,1-dioxide and their derivatives represent the most familiar class of non-steroidal anti- inflammatory drugs (NSAIDs) available in the market. In fact, Meloxicam and Piroxicam, the members of oxicam family are used as an analgesic and anti-inflammatory drugs. Azoles are potential chemical entities with a wide range of pharmacological activities such as anticancer, antibacterial, antifungal, antiviral and antiparasitic. In continuation of our efforts to develop potential multifunctional heterocycles, we have synthesized novel azolylbenzothiazine carboxamides and studied their cytotoxic and antioxidant activities. The results of these aspects will be discussed. [ABSTRACT FROM AUTHOR]

The invention of the laser, with its precise wavelength and beam divergence characteristics, coupled with the techniques like q-switching, mode locking to produce ultra-short pulses has been influencing the era of space technology. Space agencies worldwide are equipping satellites with laser transmitters in the hope of achieving crucial and vital tasks. Though, both laser technology and space operations have matured substantially in the recent decades, offering synergistic possibilities of using lasers from space-based platforms, development of a reliable laser sources meeting the space mission types and constraints is still the current quest. This paper especially focuses on the conceptualization and engineering design aspects of developing a miniaturized diode pumped, passive q-switch Er: Glass laser capable of delivering pulses of energy 3 mJ, pulse width of 7 ns at a repetition rate of 1 Hz and operating wavelength of 1535 nm. This paper sheds the light also on the selected resonator configurations, pump geometries and theoretical estimations that were performed in selection of the resonator elements keeping the miniaturization as the prime concern. Simulations of the non-linear effects like pump energy distribution, thermal lensing of the configured laser resonator design are done by employing various laser cavity and design analysis software. [ABSTRACT FROM AUTHOR]