Search

Alcohol related neuronal damage, now a day has become a global challenge as it causes liver damage, neuropathic pain, dementia, and most important is cognitive deficits. Current available pharmacological approach like antidepressant and anticonvulsant is providing insufficient or partial pain relief with habit-forming behaviour. Rutin and silymarin has antioxidant, immunomodulatory, anti-fibrotic, anti-proliferative, and anti-viral activities like potentials. Fifty four rats were distributed into nine groups and receive respective treatment. Treatment was given to rat 1 hr. before administration of alcohol (40%v/v, 10ml/kg, b.i.d, IP) for 10 weeks from day 1. All the behavior studies were evaluated at 6, 8, 10th weeks of experimentation. On the other hand, Biochemical evaluation was performed at the 10th week of study using the cortex and hippocampus of the brain of rats. Administration of ethanol (10ml/kg b.i.d) resulted in significant augmentation of cognitive deficits in rats. In our finding behavioral studies, cognitive impairment was prominently observed in a group of rats who received ethanol but the reduction in escape latency to reach the submerged platform and time spent in the targeted quadrant was reduced. Group of rats received per se of silymarin and rutin as well as rats of control group exhibited normal function in both the tests. Silymarin and rutin were given at two different doses. The investigation provides evidence for enhancement in LPO, reduction of catalase activity, and reduced glutathione in the cerebral cortex and hippocampal region of alcohol-treated rats. Comparative studies explain that both drugs produce dose-dependent improvement in activity but silymarin has better therapeutic potential than rutin. The recorded result showed protection by rutin and silymarin at individual doses but their co-administration at their lower doses produces better therapeutic efficacy over any others. [ABSTRACT FROM AUTHOR]

Calotropis procera traditionally called as Aak is a plant of Ayurvedic system having unique properties. Plant is widely distributed in tropical and subtropical areas of the world and easily available in agriculture and non-agriculture fields. Objective: The objective of the study is to develop the analytical profile. Materials and Methods: C.procera was subjected to organoleptic, physicochemical, qualitative and chromatography evaluation. Result and Discussion: The average result of total ash, acid insoluble ash, water soluble extractive and alcohol soluble extractive values were 12.53±0.11, 2.86±0.05, 25.3±0.71, 7.0±0.78. Only one principle spot (Rf= 0.45) was observed. [ABSTRACT FROM AUTHOR]

Alzheimer's disease (AD) is a degenerative geriatric disorder. Due to AD, the person suffers from memory problems and the cognition problems. It is observed that there is a necessity for the discovery and development of novel medications for AD that can slowdown or stop disease progression. This main objective of this study is to predict the biological activities of the certain phytoconstituents which are interpreted to possesses some Anti-AD activity. On the basis of the available published literature, a number of the phytoconstituents were selected for this study. The different Anti-Alzheimer's exercises of the chose phytoconstituents were deciphered by utilizing the sanctioned improved on sub-atomic info line-passage technique got from PubChem and PASS online programming. Several phytoconstituents were indicated to have better effects than licensed medications in the pharmacological intervention categories. The biological activities of the selected eight phytoconstituents were interpreted in this study by using PASS software. Following activities were predicted by using PASS software: Alzheimer's disease Treatment activity, Amyloid Beta precursor protein antagonistic activity, Amyloid Beta Aggregation inhibitory activity, Anti-inflammatory activity, Anti-oxidant activity, Beta amyloid protein antagonistic activity, cholinergic activity, Anti-dementia activity, Lipid Peroxidase inhibitory activity, Neurodegenerative Disease Treatment activity, Nootropic activity. PASS is an online valuable Software used in this study for virtually screening the chemicals and phytoconstituents for their biological activities. It was observed from this study that some phytoconstituents are found to be useful in the treatment of Alzheimer's disease. Future phytochemical studies can be performed on the basis of the findings of this study. [ABSTRACT FROM AUTHOR]

Inflammatory Bowel Disease (IBD) is a persistent bio-psychological disorder with the absence of actual pathological reason, which is diagnosed by altered bowel habits with abdominal discomfort or pain (the motility defect, distorted visceral perception of sensation, etc.). Allium sativum (Garlic), a species of the onion family Amaryllidaceae, is one of the most widely used plants in herbal medicine across the world for Inflammatory Bowel Disease. A. sativum extracts contain over 200 chemicals with various properties. The medicinal properties of A. sativum have been well-known for a long period. However, it was only in the last three decades that the properties of A. sativum were thoroughly studied, verifying its healing value. It is consumed worldwide as food known for its benefits against several diseases. A. sativum have many biological effects on human body like antibacterial, antihypertensive, antifungal, renoprotective and anti-inflammatory agent, etc. The three main underexplored phytoconstituents of A. sativum, i.e., ajoene, 2-Vinyl-4H-1,3-dithiin, and allyl methyl sulfide are considered to have anti-inflammatory and anti-ulcerative activity. The main objective of this study is to establish the effectiveness of these three phytoconstituents of garlic against Inflammatory Bowel Disease with the help of prediction of activity spectra of substances (PASS). [ABSTRACT FROM AUTHOR]

Epilepsy is one of the oldest known neurological illnesses with at least 3000 years of proven history. It is the most common neurological disorder, affecting 1-2 percent of the world's population and having a significant impact on many parts of one's quality of life. Other approaches, such as PASS prediction software, exist for determining the therapeutic use of phytochemicals. Various phytochemicals were chosen from the literature review and their action was examined in the PASS program. In the therapy or management of epilepsy, phytochemicals or medicinal plants are widely used. The main objective of this study is to predict the biological activities of the certain phytoconstituents which are interpreted to possesses some Antiseizures activity. A number of phytoconstituents were chosen for this study based on the available published literature. Using the sanctioned improved on sub-atomic information line-passage approach obtained from PubChem and PASS online programming, the various anti-seizure activities of the chosen phytoconstituents were deciphered. In the pharmacological intervention categories, several phytoconstituents were found to have better results than licensed drugs. PASS software was used to analyses the biological activities of the selected Thirty-one phytoconstituents in this investigation. Using the PASS programmed, the following activities were Anticonvulsant, GABA transport-3 inhibitor, Acute neurologic disorders treatment, Calcium regulator, GABA B receptor agonist, 5 Hydroxytryptamine uptake stimulant, Calcium channel blocker, Dementia treatment, Kainate receptor antagonist, Membrane integrity agonist, Nav1.8 sodium channel blocker, Neurotransmitter uptake inhibitor, neurodegenerative diseases treatment. PASS is a powerful online tool that was employed in this work to virtually screen compounds and phytoconstituents for biological activity. Selected phytoconstituents were discovered to be useful in the treatment of epilepsy in this investigation. The outcomes of this study can be used to guide future phytochemical research. [ABSTRACT FROM AUTHOR]

A prominent geriatric condition is benign prostatic hyperplasia. This is a non malignant [non-cancerous] growth of prostate gland, which is commonly known as fibromyoadenoma. Intra - tumoral endogenous testosterone are required for the survivability, proliferation, and amplification of prostate cancer cells. Gugulipid is a preparation of the Indian Traditional ayurvedic herb Guggul that is often used to cure a range of diseases. the computer software pass prediction of activity spectra for substances is used for the forecasting of phytochemical constituents of guggul the pass assessments of the novel compounds physiological and biochemical ranges are predicated upon structure activity relationship SAR data as well as knowledge-base SAR base that compiles the findings of the training data set to study pass anticipates this range depending on SAR analysis of a training data set including over 30 000 chemicals with over 500 different biological functions the pass technique has the benefit of requiring just two annotated data pools for drug and nondrug instances to allow for accurate estimation of categorization of given attributes, despite significant advancement in the area of therapeutic approaches for diseases ,the oleogum resin or guggul lipid is a yellow viscous liquid substance that contains a slew of active pharmaceutical components such as α-camphorene a guggulsterone with numerous activities. In this article we Stratified the major functional phytoconstituents of guggul with the aid of PASS(prediction of activity spectra of substance) for predicting the activity of guggulphytoconstituents on Benign prostate hyperplasia when compared to standard marketed formulation Finasteride. [ABSTRACT FROM AUTHOR]