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2. 826-P: Effect of Finerenone on Occurrence of Vision-Threatening Events in Patients with DR
- Author
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ROSSING, PETER, primary, ANKER, STEFAN, additional, GARWEG, JUSTUS G., additional, OSONOI, TAKESHI, additional, PITT, BERTRAM, additional, ROSAS, SYLVIA, additional, RUILOPE, LUIS M., additional, ZHU, DALONG, additional, BRINKER, MEIKE DANIELA, additional, FINIS, DAVID, additional, LEAL, SERGIO, additional, SCHMELTER, THOMAS, additional, and BAKRIS, GEORGE, additional
- Published
- 2022
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3. Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study
- Author
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Rossing, Peter, primary, Burgess, Ellen, additional, Agarwal, Rajiv, additional, Anker, Stefan D., additional, Filippatos, Gerasimos, additional, Pitt, Bertram, additional, Ruilope, Luis M., additional, Gillard, Pieter, additional, MacIsaac, Richard J., additional, Wainstein, Julio, additional, Joseph, Amer, additional, Brinker, Meike, additional, Roessig, Lothar, additional, Scott, Charlie, additional, Bakris, George L., additional, Vallejos, Augusto, additional, MacIsaac, Richard, additional, Schernthaner, Guntram, additional, Canziani, Maria Eugenia F., additional, Temelkova-Kurktschiev, Theodora, additional, Tobe, Sheldon, additional, González, Fernando, additional, Liu, Zhi-Hong, additional, Ángelo, Andrés, additional, Bonfanti, Cadena, additional, Francisco Jaramillo, Carlos, additional, Prazny, Martin, additional, Rossing, Peter, additional, Strand, Jorma, additional, Marre, Michel, additional, Schmieder, Roland, additional, Wanner, Christoph, additional, Sarafidis, Pantelis A., additional, Chan, Juliana, additional, Rosivall, László, additional, Eustace, Joseph, additional, Grossman, Ehud, additional, Yagil, Yoram, additional, Remuzzi, Giuseppe, additional, Koya, Daisuke, additional, Wada, Takashi, additional, Madero Rovalo, Magdalena, additional, Gansevoort, Ron, additional, Kooy, Adriaan, additional, Finnes, Trine, additional, De Leon, Froilan, additional, Gumprecht, Janusz, additional, Teixeira e Costa, Fernando, additional, Dreval, Alexander, additional, Vathsala, Anantharaman, additional, Amod, Aslam, additional, Gon Kim, Sin, additional, Wan Lee, Byung, additional, Pascual Santos, Julio, additional, Tengmark, Bengt-Olov, additional, Burnier, Michel, additional, Lee, Chien-Te, additional, Yamwong, Sukit, additional, Sari, Ramazan, additional, McCafferty, Kieran, additional, Mankovsky, Borys, additional, Adler, Sharon, additional, Fried, Linda, additional, Toto, Robert, additional, Williams, Mark, additional, Quang Khanh, Tran, additional, Aizenberg, Diego, additional, Bartolacci, Inés, additional, Besada, Diego, additional, Bittar, Julio, additional, Chahin, Mariano, additional, Elbert, Alicia, additional, Gelersztein, Elizabeth, additional, Liberman, Alberto, additional, Maffei, Laura, additional, Pérez Manghi, Federico, additional, Sanabria, Hugo, additional, Viñes, Gloria, additional, Wassermann, Alfredo, additional, Abhayaratna, Walter, additional, Acharya, Shamasunder, additional, Ekinci, Elif, additional, Lee, Darren, additional, Mann Mah, Peak, additional, Nelson, Craig, additional, Packham, David, additional, Pape, Alexia, additional, Roger, Simon, additional, Stephenson, Hugo, additional, Suranyi, Michael, additional, Wittert, Gary, additional, Vale, Elizabeth, additional, Clodi, Martin, additional, Ebenbichler, Christoph, additional, Fliesser-Görzer, Evelyn, additional, Hanusch, Ursula, additional, Krebs, Michael, additional, Lhotta, Karl, additional, Ludvik, Bernhard, additional, Mayer, Gert, additional, Neudorfer, Peter, additional, Paulweber, Bernhard, additional, Prager, Rudolf, additional, Preiß, Wolfgang, additional, Prischl, Friedrich, additional, Schernthaner, Gerit-Holger, additional, Sourij, Harald, additional, Wiesholzer, Martin, additional, Doubel, Peter, additional, Engelen, Wendy, additional, Hougardy, Jean-Michel, additional, Krzesinski, Jean-Marie, additional, Maes, Bart, additional, Speeckaert, Marijn, additional, Stas, Koen, additional, van Gaal, Luc, additional, Vanbelleghem, Hilde, additional, Antunes, Daniela, additional, Botelho, Roberto, additional, Brito, Claudia, additional, Canani, Luis, additional, Eugenia Canziani, Maria, additional, Cerqueira, Maria, additional, de Paula, Rogerio, additional, Eliaschewitz, Freddy, additional, Eduardo Figueiredo, Carlos, additional, Forti, Adriana, additional, Hissa, Miguel, additional, Leite Jr, Maurilo, additional, Lima, Emerson, additional, Noronha, Irene, additional, Paolino, Bruno, additional, Paschoalin, Nathalia, additional, Paschoalin, Raphael, additional, Pecoits Filho, Roberto, additional, Pereira, Marcio, additional, Portes, Evandro, additional, Precoma, Dalton, additional, Rea, Rosangela, additional, Riella, Miguel, additional, Eduardo Salles, Joao, additional, Vasconcellos, Eduardo, additional, Vencio, Sergio, additional, Apostolova, Emiliya, additional, Boshnyashka, Radostina, additional, Farah, Ghassan, additional, Georgiev, Dimitar, additional, Gushterova, Valentina, additional, Klyuchkova, Neli, additional, Lucheva, Mariya, additional, Manova, Petya, additional, Minkova, Dotska, additional, Nonchev, Boyan, additional, Pichmanova, Mariyana, additional, Prakova, Zhulieta, additional, Rangelov, Rangel, additional, Rashkov, Rosen, additional, Stanchev, Pavel, additional, Stoyanovska-Elencheva, Bilyana, additional, Tagarev, Zhivko, additional, Temelkova-Kurktschieva, Theodora, additional, Vasileva, Svetla, additional, Yoncheva-Mihaylova, Mariana, additional, Barre, Paul, additional, Carlson, Brian, additional, Conway, James, additional, Cournoyer, Serge, additional, Dumas, Richard, additional, Fikry, Sameh, additional, Goluch, Richard, additional, Hamet, Pavel, additional, Hart, Randolph, additional, Henein, Sam, additional, Liutkus, Joanne, additional, Madore, Francois, additional, Martinho, Valdemar, additional, Mazza, Giuseppe, additional, McFarlane, Philip, additional, O'Keefe, Dennis, additional, Peterson, Sean, additional, Schwartz, Daniel, additional, Shu, Daniel, additional, Steele, Andrew, additional, Tellier, Guy, additional, Tennankore, Karthik, additional, Tsoukas, George, additional, Tytus, Richard, additional, Vitou, Louise, additional, Walsh, Michael, additional, Weisnagel, Stanley, additional, Wilderman, Igor, additional, Yale, Jean-Francois, additional, Cobos, Jorge, additional, Godoy, Juan, additional, Lobos, Sergio, additional, Carlos Palma, Juan, additional, Carlos Prieto, Juan, additional, Reyes, Eliana, additional, Romero, Carmen, additional, Saavedra, Victor, additional, Vega, Mario, additional, Bu, Ruifang, additional, Cai, Hanqing, additional, Chen, Nan, additional, Chen, Qinkai, additional, Chen, Dejun, additional, Cheng, Jinluo, additional, Dong, Youping, additional, Dong, Junwu, additional, Guan, Tianjun, additional, Hao, Chuanming, additional, Huang, Wen, additional, Jiang, Fangfang, additional, Lei, Minxiang, additional, Li, Ling, additional, Li, Zhonghe, additional, Li, Xuemei, additional, Li, Jingmei, additional, Li, Yan, additional, Liang, Xinling, additional, Liang, Bo, additional, Liu, Fang, additional, Liu, Yinghong, additional, Liu, Yuantao, additional, Liu, Zhihong, additional, Long, Gang, additional, Lu, Guoyuan, additional, Lu, Weiping, additional, Lu, Yibing, additional, Luo, Ping, additional, Ma, Jianhua, additional, Mo, Zhaohui, additional, Niu, Jianying, additional, Peng, Ai, additional, Shen, Jiansong, additional, Shen, Feixia, additional, Shi, Bingyin, additional, Su, Qing, additional, Sun, Zhuxing, additional, Tang, Shuifu, additional, Tong, Nanwei, additional, Wang, Hao, additional, Wang, Xinjun, additional, Wang, Lihua, additional, Wang, Guixia, additional, Wang, Jianqin, additional, Wang, Yangang, additional, Wang, Li, additional, Wei, Jiali, additional, Wu, Tianfeng, additional, Wu, Chaoqing, additional, Xing, Changying, additional, Xiong, Fei, additional, Xu, Xudong, additional, Xu, Ning, additional, Yan, Tiekun, additional, Yang, Jinkui, additional, Yin, Aiping, additional, Zeng, Longyi, additional, Zhang, Hao, additional, Zhang, Yanlin, additional, Zhang, Ying, additional, Zhao, Wenjing, additional, Zhao, Zhiquan, additional, Zheng, Hongguang, additional, Zhong, Ling, additional, Zhu, Dalong, additional, Zhuang, Yongze, additional, Arango, Clara, additional, Barrera, Sandra, additional, Beltrán López, Nelly, additional, Benitez, Diego, additional, Blanco, Guillermo, additional, Cadena, Andrés, additional, Coronel, Julian, additional, Cure, Carlos, additional, Durán, Carlos, additional, González, Alexander, additional, Guzmán, Gustavo, additional, Hernández, Eric, additional, Ibarra, Jaime, additional, Jaramillo, Carlos, additional, Jaramillo, Nicolás, additional, Kattah, William, additional, Molina, Dora, additional, Sánchez, Gregorio, additional, Terront, Mónica, additional, Trujillo, Freddy, additional, Urina, Miguel, additional, Vargas, Ruben, additional, Villegas, Iván, additional, Yupanqui, Hernán, additional, Alferi, Dino, additional, Brada, Michal, additional, Brezina, Jiri, additional, Bucek, Petr, additional, Edelsberger, Tomas, additional, Gulakova, Drahomira, additional, Hasalova Zapletalova, Jitka, additional, Hola, Olga, additional, Hornova, Lucie, additional, Houdova, Jana, additional, Hrmova, Helena, additional, Karasek, David, additional, Kopecka, Sarka, additional, Kovar, Richard, additional, Krcova, Eva, additional, Kuchar, Jiri, additional, Kutejova, Vlasta, additional, Lubanda, Hana, additional, Matyasek, Ivo, additional, Mokrejsova, Magdalena, additional, Okenka, Libor, additional, Pumprla, Jiri, additional, Tomanek, Pavel, additional, Bech, Jesper, additional, Faber, Jens, additional, Gislason, Gunnar, additional, Hangaard, Jørgen, additional, Jaroslaw Pacyk, Grzegorz, additional, Juhl, Claus, additional, Krarup, Thure, additional, Lindhardt, Morten, additional, Madsbad, Sten, additional, Nielsen, Joan, additional, Pedersen-Bjergaard, Ulrik, additional, Poulsen, Per, additional, Rasmussen, Ole, additional, Schousboe, Karoline, additional, Honkasalo, Mikko, additional, Humaloja, Kari, additional, Kananen, Kristiina, additional, Kantola, Ilkka, additional, Koistinen, Arvo, additional, Korsoff, Pirkko, additional, Lahtela, Jorma, additional, Nieminen, Sakari, additional, Nieminen, Tuomo, additional, Sadeharju, Karita, additional, Sulosaari, Sakari, additional, Cariou, Bertrand, additional, Chantrel, François, additional, Clavel, Sylvaine, additional, Combe, Christian, additional, Fauvel, Jean-Pierre, additional, Gallouj, Karim, additional, Gouet, Didier, additional, Guerci, Bruno, additional, Guerrot, Dominique, additional, Hourmant, Maryvonne, additional, Klein, Alexandre, additional, Mariat, Christophe, additional, Mesbah, Rafik, additional, Le Meur, Yannick, additional, Monier, Arnaud, additional, Moranne, Olivier, additional, Serusclat, Pierre, additional, Vendrely, Benoit, additional, Verges, Bruno, additional, Zaoui, Philippe, additional, Axthelm, Christoph, additional, Bergmann, Andreas, additional, Birkenfeld, Andreas L., additional, Braun, Hermann, additional, Busch, Klaus, additional, Contzen, Christel, additional, Degenhardt, Stefan, additional, Derwahl, Karl, additional, Giebel, Thomas, additional, Hagenow, Andreas, additional, Haller, Hermann, additional, Hasslacher, Christoph, additional, Horacek, Thomas, additional, Jungmair, Wolfgang, additional, Kloos, Christof, additional, Koch, Thorsten, additional, Krüger, Thilo, additional, Mühlfeld, Anja, additional, Müller, Joachim, additional, Pfützner, Andreas, additional, Pistrosch, Frank, additional, Rose, Ludger, additional, Rump, Lars, additional, Schettler, Volker, additional, Schiefke, Ingolf, additional, Schlichthaar, Heike, additional, Schröppel, Bernd, additional, Schürholz, Thomas, additional, Sigal, Helena, additional, Stemler, Lutz, additional, Strack, Georg, additional, Täschner, Heidrun, additional, Toursarkissian, Nicole, additional, Tschöpe, Diethelm, additional, Ulmer, Achim, additional, van der Giet, Markus, additional, Winkelmann, Bernhard R., additional, Boletis, Ioannis, additional, Hatziagelaki, Erifili, additional, Ioannidis, Ioannis, additional, Kounadi, Theodora, additional, Makriniotou, Ioanna, additional, Papadopoulou, Dorothea, additional, Papagianni, Aikaterini, additional, Passadakis, Ploumis, additional, Stefanidis, Ioannis, additional, Pang Ip, Tai, additional, Lee, Paul, additional, Yan Andrea Luk, On, additional, Wang, Angela, additional, Yeung, Vincent, additional, Bajcsi, Dora, additional, Danos, Peter, additional, Harcsa, Eleonora, additional, Kazup, Szilvia, additional, Keltai, Katalin, additional, Kirschner, Robert, additional, Kiss, Julianna, additional, Kovacs, Laszlo, additional, Lamboy, Beata, additional, Literati-Nagy, Botond, additional, Mileder, Margit, additional, Nagy, Laszlo, additional, Noori, Ebrahim, additional, Nyirati, Gabor, additional, Petro, Gizella, additional, Schneider, Karoly, additional, Szocs, Albert, additional, Vasas, Szilard, additional, Wudi, Krisztina, additional, Zilahi, Zsolt, additional, Zsom, Marianna, additional, Eustace, Joe, additional, Holian, John, additional, Reddan, Donal, additional, O'Meara, Yvonne, additional, Abramof Ness, Rosane, additional, Adawi, Faiad, additional, Armaly, Zaher, additional, Atar, Shaul, additional, Ben Chetrit, Sydney, additional, Berar Yanay, Noa, additional, Chernin, Gil, additional, Darawsha, Mahmud, additional, Efrati, Shai, additional, Elias, Mazen, additional, Farber, Evgeny, additional, Glandt, Mariela, additional, Halabi, Majdi, additional, Khazim, Khaled, additional, Liberty, Idit, additional, Mosenzon, Ofri, additional, Nimer, Assy, additional, Schwartz, Doron, additional, Zukermann, Robert, additional, Ilieva Parvanova, Aneliya, additional, Avogaro, Angelo, additional, Giorgio Battaglia, Giovanni, additional, Tiziano Bevilacqua, Maurizio, additional, Bonora, Enzo, additional, Antonio Bossi, Carlo, additional, Calabrò, Paolo, additional, Luigi Cavalot, Franco, additional, Cimino, Roberto, additional, Gennaro Cozzolino, Mario, additional, David, Salvatore, additional, Emdin, Michele, additional, Fiaccadori, Enrico, additional, Fiorina, Paolo, additional, Bruno Giorda, Carlo, additional, Cristina Gregorini, Maria, additional, La Manna, Gaetano, additional, Carlo Maggi, Davide, additional, Manti, Roberta, additional, Meregalli, Giancarla, additional, Pani, Antonello, additional, Perico, Norberto, additional, Piatti, PierMarco, additional, Pisani, Antonio, additional, Ettore Pontiroli, Antonio, additional, Ponzani, Paola, additional, Santorelli, Gennaro, additional, Santoro, Domenico, additional, Scanziani, Renzo, additional, Teatini, Ugo, additional, Tonolo, Giancarlo, additional, Trevisan, Roberto, additional, Maria Veronelli, Anna, additional, Luciano Viviani, Giorgio, additional, Araki, Hideo, additional, Ebisui, Osamu, additional, Fujita, Naruhiro, additional, Furuya, Ryuichi, additional, Hamamoto, Yoshiyuki, additional, Hatazaki, Masahiro, additional, Hayashi, Terumasa, additional, Higashi, Takayuki, additional, Hirohata, Yoshihide, additional, Horinouchi, Shuji, additional, Inagaki, Masayuki, additional, Ishii, Masao, additional, Ishiko, Tamayo, additional, Jinnouchi, Hideaki, additional, Kanai, Hidetoshi, additional, Kanda, Daisuke, additional, Kanehara, Hideo, additional, Kashima, Masayuki, additional, Kato, Kiyoe, additional, Katsuki, Takeshi, additional, Kawamitsu, Katsunori, additional, Kawasaki, Satsuki, additional, Kikuchi, Fumi, additional, Kikuchi, Hidetoshi, additional, Kobayashi, Kunihisa, additional, Koide, Junko, additional, Kubota, Miyuki, additional, Kusano, Yoshiro, additional, Maeda, Hajime, additional, Matsubayashi, Sunao, additional, Matsumoto, Kazunari, additional, Matsuo, Yasuto, additional, Matsuoka, Naoki, additional, Miyaoka, Hiroaki, additional, Murao, Satoshi, additional, Nakayama, Mikihiro, additional, Nakazawa, Jun, additional, Nomiyama, Takashi, additional, Noritake, Masayuki, additional, Ogiwara, Takayuki, additional, Ohashi, Hiroshi, additional, Okamoto, Hideki, additional, Osonoi, Takeshi, additional, Sasaki, Nobuhiro, additional, Sekigami, Taiji, additional, Shibasaki, Taro, additional, Shibata, Hirotaka, additional, Shinoda, Junji, additional, Sobajima, Hiroshi, additional, Sugitatsu, Kazuya, additional, Sugiura, Toshiyuki, additional, Sugiyama, Toru, additional, Suzuki, Daisuke, additional, Suzuki, Hiroyuki, additional, Suzuki, Masaaki, additional, Takeda, Asami, additional, Tanaka, Asami, additional, Tanaka, Seiichi, additional, Tsunematsu, Izumi, additional, Ujihara, Makoto, additional, Yamada, Daishiro, additional, Yamada, Masayo, additional, Yamagata, Kazuo, additional, Yamakawa, Ken, additional, Yamakawa, Fumiko, additional, Yamasaki, Yoshimitsu, additional, Yambe, Yuko, additional, Yanagida, Taihei, additional, Yanai, Hidekatsu, additional, Yasuda, Tetsuyuki, additional, Kriauciuniene, Dovile, additional, Lasiene, Jurate, additional, Navickas, Antanas, additional, Radzeviciene, Lina, additional, Urbanaviciene, Egle, additional, Urbonas, Gediminas, additional, Velaviciene, Audrone, additional, Abd Ghani, Rohana, additional, Azizah Aziz, Nor, additional, Yuan Lee, Li, additional, Loong Loh, Chek, additional, Mohd Ali, Norhaliza, additional, Mohd Noor, Nurain, additional, Nur Fatnoon, Nik, additional, Ahmad, Nik, additional, Ratnasingam, Jeyakantha, additional, Hasnul Halimi Bin, Wan, additional, Hasan, Wan, additional, Mohd Izani, Wan, additional, Mohamed, Wan, additional, Avila Pardo, Sandro, additional, Bastidas Adrian, Miriam, additional, Chew Wong, Alfredo, additional, Escobedo de la Peña, Jorge, additional, Fanghänel Salmón, Guillermo, additional, González Gálvez, Guillermo, additional, Gutiérrez Ochoa, Ramiro, additional, Irizar Santana, Saúl, additional, Méndez Machado, Gustavo, additional, Nevarez Ruiz, Luis, additional, Ramos Ibarra, Denisse, additional, Ramos López, Gabriel, additional, Sauque Reyna, Leobardo, additional, Solache Ortiz, Gustavo, additional, Valdez Ortiz, Rafael, additional, Villagordoa Mesa, Juan, additional, Bakker, R.C., additional, Barendregt, J.N.M., additional, Boonstra, A.H., additional, Bos, Willem, additional, Brouwer, C.B., additional, van Buren, M., additional, Krekels, Marielle, additional, van Leendert, Ruud J.M., additional, Lieverse, Louis A.G., additional, Luik, P.T., additional, Lars Penne, E., additional, Smak Gregoor, Peter, additional, Vogt, Liffert, additional, Baker, John, additional, Crawford, Veronica, additional, Cutfield, Rick, additional, Dunn, Peter, additional, Krebs, Jeremy, additional, Nirmalaraj, Kingsley, additional, Scott, Russell, additional, Smuts, Nine, additional, Eriksen, Erik, additional, Høivik, Hans, additional, Karlsson, Thomas, additional, Scott Munk, Peter, additional, Radtke, Maria, additional, Risberg, Knut, additional, Rocke, Jan, additional, Solnør, Leidulv, additional, Stenehjem, Aud-Eldrid, additional, Tafjord, Anne-Beathe, additional, Pamugas, Glenda, additional, Panelo, Araceli, additional, Perez, Ronald, additional, Tanque, Maribel, additional, Tirador, Louie, additional, Villa, Michael, additional, Butrymowicz, Patrycja, additional, Ciechanowski, Kazimierz, additional, Cieslik, Grazyna, additional, Franek, Edward, additional, Hoffmann, Michal, additional, Krzykowska, Jolanta, additional, Kurnatowska, Ilona, additional, Landa, Katarzyna, additional, Madrzejewski, Adam, additional, Madziarska, Katarzyna, additional, Mazur, Stanislaw, additional, Napora, Piotr, additional, Nowicki, Michal, additional, Ocicka-Kozakiewicz, Anna, additional, Rewerska, Barbara, additional, Rusicka, Teresa, additional, Ruxer, Jan, additional, Skokowska, Ewa, additional, Stankiewicz, Andrzej, additional, Stompor, Tomasz, additional, Tiuryn-Petrulewicz, Agnieszka, additional, Wasilewska, Katarzyna, additional, Wierusz-Wysocka, Bogna, additional, Wnetrzak-Michalska, Renata, additional, Almeida, Edgar, additional, Ballesteros, Rosa, additional, Barreto, Carlos, additional, Beirao, Idalina, additional, Birne, Rita, additional, Esteves, Cesar, additional, Guia, Jose, additional, Heitor, Susana, additional, Marques, Olinda, additional, Melo, Pedro, additional, Nolasco, Fernando, additional, Pereira, Amalia, additional, Roque, Cristina, additional, Rosario, Francisco, additional, Silva, Gil, additional, Silva, Ana, additional, Vila Lobos, Ana, additional, Cortes-Maisonet, Gregorio, additional, Roman-Miranda, Amaury, additional, Albota, Adrian, additional, Bala, Cornelia, additional, Barbonta, Hortensia, additional, Caceaune, Elena, additional, Catrinoui, Doina, additional, Constantin, Ciprian, additional, Dumitrescu, Adriana, additional, Mindrescu, Nicoleta, additional, Mistode, Cristina, additional, Negrisanu, Gabriela, additional, Onaca, Adriana, additional, Paveliu, Silvia, additional, Pintilei, Ella, additional, Pop, Lavinia, additional, Popa, Amorin, additional, Popescu, Alexandrina, additional, Radulian, Gabriela, additional, Szilagyi, Iosif, additional, Turcu, Liana, additional, Vacaru, Georgeta, additional, Vlad, Adrian, additional, Antsiferov, Mikhail, additional, Arkhipov, Mikhail, additional, Babkin, Andrey, additional, Barbarash, Olga, additional, Baranov, Vitaliy, additional, Chernyavskaya, Elena, additional, Demko, Arkadiy, additional, Edin, Anton, additional, Ermakova, Polina, additional, Fadeev, Valentin, additional, Galyavich, Albert, additional, Gaysina, Leyla, additional, Gordeev, Ivan, additional, Ipatko, Irina, additional, Kalashnikova, Marina, additional, Khalimov, Yuriy, additional, Klimontov, Vadim, additional, Kobalava, Zhanna, additional, Kosmacheva, Elena, additional, Koziolova, Natalya, additional, Kvitkova Sergey Levashov, Lyudmila, additional, Libis, Roman, additional, Marasaev, Vyacheslav, additional, Malykh, Natalia, additional, Martynenko, Vladimir, additional, Malyutina, Sofya, additional, Merai, Imad, additional, Mkrtumyan, Ashot, additional, Nechaeva, Galina, additional, Petunina, Nina, additional, Palyutin, Shamil, additional, Pimenov, Leonid, additional, Rechkova, Elena, additional, Rodionova, Tatyana, additional, Rymar, Oksana, additional, Sardinov, Ruslan, additional, Semenova, Olga, additional, Sherenkov, Alexander, additional, Solovev, Oleg, additional, Smolyarchuk, Elena, additional, Strongin, Leonid, additional, Ukhanova, Olga, additional, Verlan, Nadezhda, additional, Vorokhobina, Natalya, additional, Yakhontov, Davyd, additional, Yakushin, Sergey, additional, Zakharova, Elena, additional, Zalevskaya, Alsu, additional, Zanozina, Olga, additional, Zhdanova, Elena, additional, Zhukova, Larisa, additional, Zykova, Tatyana, additional, Fang Sum, Chee, additional, Muhummad Suhail, Sufi, additional, San Tan, Ru, additional, Wong, Edmund, additional, Babikova, Jana, additional, Buganova, Ingrid, additional, Dzupina, Andrej, additional, Ochodnicka, Zuzana, additional, Sosovec, Dalibor, additional, Spodniakova, Denisa, additional, Ahmed, Fayzal, additional, Bhana, Sindeep, additional, Distiller, Larry, additional, Jansen van Rensburg, Dirkie, additional, Joshi, Mukesh, additional, Joshi, Shaifali, additional, Lakha, Deepak, additional, Mitha, Essack, additional, Podgorski, Gracjan, additional, Ranjith, Naresh, additional, Rayner, Brian, additional, Rheeder, Paul, additional, Sarvan, Mohamed, additional, Seeber, Mary, additional, Siebert, Heidi, additional, Tayob, Mohammed, additional, Trokis, Julien, additional, Urbach, Dorothea, additional, van Zyl, Louis, additional, Choi, Bum-Soon, additional, Gi Choi, Moon, additional, Chung, ChoonHee, additional, Hwang, YouCheol, additional, Kim, ChongHwa, additional, Kim, InJoo, additional, Kim, JaeHyeon, additional, Kim, SinGon, additional, Kim, SungGyun, additional, Hee Kim, Tae, additional, Lee, WooJe, additional, Lee, ByungWan, additional, Wook Lee, Kang, additional, Oh, Kook-Hwan, additional, Eun Oh, Ji, additional, Kyu Oh, Yun, additional, Oh, Dong-Jin, additional, Park, Junbeom, additional, Joon Shin, Seok, additional, Sung, Su-Ah, additional, Myung Yu, Jae, additional, Agraz, Irene, additional, Javier Ampudia, Francisco, additional, Bouarich, Hanane, additional, Calero, Francesca, additional, Castro, Cristina, additional, Cigarrán Guldris, Secundino, additional, Cruzado Garrit, Josep, additional, de Álvaro, Fernando, additional, Galcerán, Josep, additional, González Albarrán, Olga, additional, Hernández Jaras, Julio, additional, Ibernón, Meritxell, additional, Martínez Deben, Francisco, additional, Dolores Martínez Esteban, Ma, additional, María Pascual Izuel, José, additional, Martins, Judith, additional, Mediavilla, Juan, additional, Michán, Alfredo, additional, Poch, Esteban, additional, Polaina Rusillo, Manuel, additional, Sánchez Juan, Carlos, additional, Santamaría Olmo, Rafael, additional, Julián, José, additional, de la Morena, Segura, additional, Soto, Alfonso, additional, Troya, Maribel, additional, Bruchfeld, Annette, additional, Curiac, Dan, additional, Eliasson, Ken, additional, Frank, Malin, additional, Guron, Gregor, additional, Hellberg, Olof, additional, Hellgren, Margareta, additional, Larnefeldt, Hans, additional, Lindholm, Carl-Johan, additional, Löndahl, Magnus, additional, Rein-Hedin, Erik, additional, Soveri, Inga, additional, Spaak, Jonas, additional, Ackermann, Daniel, additional, Bilz, Stefan, additional, Forster, Christian, additional, Kalbermatter, Stefan, additional, Kistler, Andreas, additional, Pechére-Bertschi, Antoinette, additional, Schultes, Bernd, additional, Chang, Chiz-Tzung, additional, Hung, Cheng-Chieh, additional, Jiang, Ju-Ying, additional, Lin, Shuei-Liong, additional, Tarng, Der-Cherng, additional, Tu, Shih-Te, additional, Wu, Mai-Szu, additional, Wu, Ming-Ju, additional, Deerochanawong, Chaicharn, additional, Kitiyakara, Chagriya, additional, Ophascharoensuk, Vuddhidej, additional, Pongchaiyakul, Chatlert, additional, Satirapoj, Bancha, additional, Eren, Necmi, additional, Gul, Ibrahim, additional, Gulel, Okan, additional, Kocyigit, Ismail, additional, Kumbasar, Abdulbaki, additional, Sahin, Idris, additional, Sayin, Burak, additional, Tavli, Talat, additional, Ustundag, Sedat, additional, Yenicerioglu, Yavuz, additional, Bondarets, Iryna, additional, Botsyurko, Volodymyr, additional, Chernikova, Viktoriia, additional, Donets, Oleksandra, additional, Fushtey, Ivan, additional, Grachova, Mariia, additional, Isayeva, Anna, additional, Kogut, Dmytro, additional, Komisarenko, Julia, additional, Kravchun, Nonna, additional, Malyar, Kateryna, additional, Martynyuk, Liliya, additional, Maslyanko, Vitaliy, additional, Myshanych, Halyna, additional, Pererva, Larysa, additional, Pertseva, Nataliia, additional, Serhiyenko, Oleksandr, additional, Smirnov, Ivan, additional, Sokolova, Liubov, additional, Stryzhak, Vasyl, additional, Vlasenko, Maryna, additional, AbouSaleh, Ahmad, additional, Barratt, Jonathan, additional, Dang, Cuong, additional, Kahal, Hassan, additional, Kirk, Adam, additional, Kilvert, Anne, additional, Phi Kon, Sui, additional, Patel, Dipesh, additional, Rice, Sam, additional, Vijayaraman, Arutchelvam, additional, Wong, Yuk-ki, additional, Gibson, Martin, additional, Wahba, Mona, additional, Zaidi, Reza, additional, Acosta, Idalia, additional, Adams, Atoya, additional, Ajani, Dilawar, additional, Ali, Slamat, additional, Alicic, Radica, additional, Al-Karadsheh, Amer, additional, Alla, Sreedhara, additional, Allison, D., additional, Andrawis, Nabil, additional, Arif, Ahmed, additional, Awad, Ahmed, additional, Azizad, Masoud, additional, Bahrami, Michael, additional, Bansal, Shweta, additional, Barag, Steven, additional, Barakzoy, Ahmad, additional, Barney, Mark, additional, Barzilay, Joshua, additional, Bashir, Khalid, additional, Bautista, Jose, additional, Beddhu, Srinivasan, additional, Belo, Diogo, additional, Benjamin, Sabrina, additional, Berenji, Ramin, additional, Bhargava, Anuj, additional, Birriel, Jose, additional, Brietzke, Stephen, additional, Brosius, Frank, additional, Brusco, Osvaldo, additional, Burgner, Anna, additional, Busch, Robert, additional, Canadas, Rafael, additional, Caramori, Maria, additional, Cardona, Jose, additional, Case, Christopher, additional, Cruz, Humberto, additional, Dandillaya, Ramprasad, additional, Dawoud, Dalia, additional, Din, Zia, additional, Dixon, Bradley, additional, Doshi, Ankur, additional, Drakakis, James, additional, El Shahawy, Mahfouz, additional, El-Meanawy, Ashraf, additional, El-Shahawy, Mohammed, additional, Evans, John, additional, Fadda, George, additional, Farooq, Umar, additional, Fernando, Roland, additional, Fink, Raymond, additional, First, Brian, additional, Fitz-Patrick, David, additional, Flack, John, additional, Fluck, Patrick, additional, Fogelfeld, Leon, additional, Fonseca, Vivian, additional, Frias, Juan, additional, Galphin, Claude, additional, Garcia-Mayol, Luis, additional, Goldstein, Gary, additional, Gonzalez, Edgar, additional, Gonzalez-Abreu, Francisco, additional, Gore, Ashwini, additional, Grant, David, additional, Habwe, Violet, additional, Hamilton, Maxine, additional, Hammoud, Jamal, additional, Handelsman, Stuart, additional, Hartman, Israel, additional, Heigerick, Glenn, additional, Henry, Andrew, additional, Hernandez, German, additional, Hernandez-Cassis, Carlos, additional, Herrera, Carlos, additional, Hertel, Joachim, additional, Huang, Wenyu, additional, Iglesias, Rogelio, additional, Iranmanesh, Ali, additional, Jackson, Timothy, additional, Jain, Mahendra, additional, Jamerson, Kenneth, additional, Johnson, Karen, additional, Judd, Eric, additional, Kaplan, Joshua, additional, Kayali, Zeid, additional, Khan, Bobby, additional, Khan, Muhammad, additional, Kharait, Sourabh, additional, Sue Kirkman, M., additional, Kopyt, Nelson, additional, Kotzker, Wayne, additional, Kovesdy, Csaba, additional, Kreit, Camil, additional, Krishna, Arvind, additional, Kronfli, Saeed, additional, Lee, Keung, additional, LeJeune, Derek, additional, Lemus, Brenda, additional, Leon-Forero, Carlos, additional, Linfert, Douglas, additional, Lora, Henry, additional, Lurie, Alexander, additional, Maddukuri, Geetha, additional, Magno, Alexander, additional, Maletz, Louis, additional, Mandayam, Sreedhar, additional, Markell, Mariana, additional, Mayfield, Ronald, additional, Mbogua, Caroline, additional, McMullen, Dierdre, additional, Meisner, Carl, additional, Minton, Stephen, additional, Mocherla, Bharat, additional, Mohandas, Rajesh, additional, Montero, Manuel, additional, Moustafa, Moustafa, additional, Nadkarni, Salil, additional, Nakhle, Samer, additional, Navarro, Jesus, additional, Neyra, Nilda, additional, Nica, Romanita, additional, Nicol, Philip, additional, Norwood, Paul, additional, Numrungroad, Visal, additional, O'Donovan, Richard, additional, Odugbesan, A., additional, Paoli-Bruno, Jorge, additional, Parikh, Samir, additional, Patel, Rakesh, additional, Peixoto, Aldo, additional, Pergola, Pablo, additional, Perlman, Alan, additional, Pettis, Karlton, additional, Pisoni, Roberto, additional, Ponduchi, Mirela, additional, Posada, Jorge, additional, Prabhakar, Sharma, additional, Radhakrishnan, Jai, additional, Rahman, Mahboob, additional, Raina, Rupesh, additional, Rastogi, Anjay, additional, Reisin, Efrain, additional, Rendell, Marc, additional, Robertson, David, additional, Rocco, Michael, additional, Romeu, Hugo, additional, Rosas, Sylvia, additional, Rosenfeld, Jack, additional, Ross, Dennis, additional, Rothman, Jeffrey, additional, Rudolph, Lance, additional, Ruhullah, Yusuf, additional, Ruoff, Gary, additional, Ryu, Jeffrey, additional, Sahani, Mandeep, additional, Sam, Ramin, additional, Samuels, Garfield, additional, Sanchez, William, additional, Santos, Vladimir, additional, Satko, Scott, additional, Saxena, Sanjeev, additional, Scott, David, additional, Seco, Gilberto, additional, Seek, Melvin, additional, Serota, Harvey, additional, Shafi, Tariq, additional, Shahid, Nauman, additional, Shanik, Michael, additional, Sharma, Santosh, additional, Sinha, Arjun, additional, Smelser, James, additional, Smith, Mark, additional, Soe, Kyaw, additional, Solomon, Richard, additional, Soroka, Eugene, additional, Soufer, Joseph, additional, Spinowitz, Bruce, additional, Spry, Leslie, additional, Suarez, Rosa, additional, Subramanian, Bala, additional, Szerlip, Harold, additional, Tamirisa, Aparna, additional, Thomson, Stephen, additional, Tran, Tuan-Huy, additional, Treger, Richard, additional, Trullenque, Gretel, additional, Turk, Thomas, additional, Umpierrez, Guillermo, additional, Urbach, Daniel, additional, Valdes, Martin, additional, Valika, Shujauddin, additional, Vega, Damaris, additional, Weissman, Peter, additional, Whaley-Connell, Adam, additional, Winston, Jonathan, additional, Wise, Jonathan, additional, Wynne, Alan, additional, Zeig, Steven, additional, Chu, Phuong, additional, Van Hoang, Lam, additional, Khanh, Tran, additional, Thi Phi Nga, Nguyen, additional, Nguyen Son, Pham, additional, and Phuong Tran, Lan, additional
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- 2022
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4. 235-OR: Dorzagliatin as a Glucose Sensitizer Achieved Sustained Glycemic Control with Good Safety Profiles in Drug-Naïve T2D Patients in a 52-Week Phase 3 Monotherapy Trial (SEED)
- Author
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CHEN, LI, primary, ZHANG, YI, additional, and ZHU, DALONG, additional
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- 2021
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5. Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease
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Hong, Jie, Zhang, Yifei, Lai, Shenghan, Lv, Ankang, Su, Qing, Dong, Yan, Zhou, Zhiguang, Tang, Weili, Zhao, Jiajun, Cui, Lianqun, Zou, Dajin, Wang, Dawang, Li, Hong, Liu, Chao, Wu, Guoting, Shen, Jie, Zhu, Dalong, Wang, Weiqing, Shen, Weifeng, and Ning, Guang
- Subjects
Mortality -- Maryland -- China -- Analysis ,Type 2 diabetes -- Patient outcomes -- Care and treatment -- Analysis ,Diabetics -- Patient outcomes -- Care and treatment -- Analysis ,Glipizide -- Analysis ,Health - Abstract
OBJECTIVE--The two major classes of antidiabetic drugs, sulfonylureas and metformin, may differentially affect macrovascular complications and mortality in diabetic patients. We compared the long-term effects of glipizide and metformin on [...]
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- 2013
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6. Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes
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Gu, Weiqiong, Hu, Jiong, Wang, Weiqing, Li, Lirong, Tang, Wei, Sun, Shouyue, Cui, Weijuan, Ye, Lei, Zhang, Yifei, Hong, Jie, Zhu, Dalong, and Ning, Guang
- Subjects
Ketoacidosis -- Research ,Medical research ,Cyclophosphamide -- Research ,Diabetes -- Research ,Teenagers ,Stem cells -- Transplantation ,Stem cell research ,Medicine, Experimental ,Diabetic acidosis -- Research ,Diabetes therapy ,Type 1 diabetes -- Research ,Hematopoietic stem cells -- Transplantation ,Youth ,Diabetics ,Health - Abstract
OBJECTIVE--To determine if autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) was beneficial for type 1 diabetic adolescents with diabetic ketoacidosis (DKA) at diagnosis. RESEARCH DESIGN AND METHODS--We enrolled 28 patients [...]
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- 2012
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7. 182-OR: A Novel Dual-Acting Glucokinase Activator (GKA) Dorzagliatin (HMS5552) Achieved Primary Efficacy Endpoint with Good Safety Profiles in T2DM Patients after 24 Weeks of Treatment in a Phase III Monotherapy Trial
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ZHU, DALONG, primary, ZHANG, YI, additional, and CHEN, LI, additional
- Published
- 2020
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8. 1770-P: Role of Prolactin Rhythm in the Development of Nonalcoholic Fatty Liver Disease
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YAN, BI, primary, ZHANG, PENGZI, additional, and ZHU, DALONG, additional
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- 2020
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9. 1673-P: Plasmablasts Contribute to the Development of Type 1 Diabetes via Enhancing T-Cell Cytotoxicity
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YAN, BI, primary, LING, QING, additional, LU, JING, additional, and ZHU, DALONG, additional
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- 2020
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10. Short-term intensive therapy in newly diagnosed type 2 diabetes partially restores both insulin sensitivity and β-cell function in subjects with long-term remission
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Hu, Yun, Li, Lirong, Xu, Yu, Yu, Tingting, Tong, Guoyu, Huang, Hong, Bi, Yan, Weng, Jianping, and Zhu, Dalong
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Diabetes therapy ,Diabetes -- Research ,Insulin resistance -- Care and treatment ,Pancreatic beta cells ,Insulin ,Blood sugar ,Type 2 diabetes -- Care and treatment ,Health - Abstract
OBJECTIVE--To examine the effect of intensive glycemic control therapy (IT) on insulin sensitivity and β-cell function in newly diagnosed type 2 diabetic patients compared with subjects with normal glucose tolerance [...]
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- 2011
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11. Biphasic insulin aspart 30 three times daily is more effective than a twice-daily regimen, without increasing hypoglycemia, in Chinese subjects with type 2 diabetes inadequately controlled on oral antidiabetes drugs
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Yang, Wenying, Ji, Qiuhe, Zhu, Dalong, Yang, Jinkui, Chen, Lulu, Liu, Zhimin, Yu, Demin, and Yan, Li
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Diabetes therapy ,Insulin -- Dosage and administration ,Blood sugar ,Type 2 diabetes -- Drug therapy ,Health ,Drug therapy ,Dosage and administration - Abstract
OBJECTIVE--To assess the efficacy and safety of twice- and thrice-daily biphasic insulin aspart 30 (BIAsp 30) in Chinese subjects with type 2 diabetes inadequately controlled with oral antidiabetes drugs (OADs). [...]
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- 2008
12. Association of Implementation of a Comprehensive Preconception-to-Pregnancy Management Plan With Pregnancy Outcomes Among Chinese Pregnant Women With Type 1 Diabetes: The CARNATION Study.
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Zheng, Xueying, Yang, Daizhi, Luo, Sihui, Yan, Jinhua, Guo, Xiaohui, Yang, Huixia, Bao, Wei, Groop, Leif, Dornhorst, Anne, Weng, Jianping, Liu, Fang, Xiao, Xingwu Ran Xinhua, Zhu, Dalong, Hu, Ji, Zhou, Zhiguang, Yang, Tao, Zhao, Jiajun, Huang, Qin, Kuang, Hongyu, and Liang, Zhen
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PREGNANT women ,PREGNANCY outcomes ,TYPE 1 diabetes ,NEONATAL death ,CARNATIONS ,RETROSPECTIVE studies ,LONGITUDINAL method ,PREGNANCY - Abstract
Objective: To investigate the effect on pregnancy outcome of integrating a comprehensive management plan for patients with type 1 diabetes (T1D) into the World Health Organization universal maternal care infrastructure.Research Design and Methods: A comprehensive preconception-to-pregnancy management plan for women with T1D was implemented in 11 centers from 8 Chinese cities from 2015 to 2017. Sequential eligible pregnant women (n = 133 out of 137 initially enrolled) with T1D and singleton pregnancies attending these management centers formed the prospective cohort. The main outcome was severe adverse pregnancy outcome comprising maternal mortality, neonatal death, congenital malformations, miscarriage in the second trimester, and stillbirth. We compared pregnancy outcomes in this prospective cohort with two control groups with the same inclusion and exclusion criteria: a retrospective cohort (n = 153) of all eligible pregnant women with T1D attending the same management centers from 2012 to 2014 and a comparison cohort (n = 116) of all eligible pregnant women with T1D receiving routine care from 2015 to 2017 in 11 different centers from 7 cities.Results: The rate of severe adverse pregnancy outcome was lower in the prospective cohort (6.02%) than in either the retrospective cohort (18.30%; adjusted odds ratio [aOR] 0.31 [95% CI 0.13-0.74]) or the contemporaneous comparison cohort (25.00%; aOR 0.22 [95% CI 0.09-0.52]).Conclusions: The substantial improvements in the prospective cohort are evidence of a potentially clinically important effect of the comprehensive management plan on pregnancy outcomes among Chinese pregnant women with pregestational T1D. This supports the development of similar approaches in other countries. [ABSTRACT FROM AUTHOR]- Published
- 2021
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13. 18-OR: Efficacy and Safety of Chiglitazar vs. Sitagliptin in Patients with Type 2 Diabetes: A 24-Week, Randomized, Double-Blind, Noninferiority Phase 3 Trial (CMAS)
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JIA, WEIPING, primary, MA, JIANHUA, additional, MIAO, HENG, additional, WANG, CHANGJIANG, additional, WANG, XIAOYUE, additional, LI, QUANMIN, additional, LU, WEIPING, additional, YANG, JIALIN, additional, ZHANG, LIHUI, additional, YANG, JINKUI, additional, WANG, GUIXIA, additional, ZHANG, XIUZHENG, additional, ZHANG, MIN, additional, SUN, LI, additional, YU, XUEFENG, additional, DU, JIANLING, additional, SHI, BINGYIN, additional, XIAO, CHANGQING, additional, ZHU, DALONG, additional, LIU, HONG, additional, ZHONG, LIYONG, additional, XU, CHUN, additional, XU, QI, additional, LIANG, GANXIONG, additional, ZHANG, YING, additional, LI, GUANGWEI, additional, GU, MINGYU, additional, LIU, JUN, additional, NING, ZHIQIANG, additional, and JI, LINONG, additional
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- 2019
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14. Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies
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Zhang, Zhou, primary, Zhang, Bing, additional, Wang, Xin, additional, Zhang, Xin, additional, Yang, Qing X., additional, Qing, Zhao, additional, Zhang, Wen, additional, Zhu, Dalong, additional, and Bi, Yan, additional
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- 2019
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15. Association between Vitamin D and Metabolic Indexes in Patients with Polycystic Ovary Syndrome
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SHANMEI, SHEN, primary, JIAYI, LIU, additional, YIKUN, LI, additional, CHENGCHENG, QIAO, additional, JIAMIAO, YANG, additional, BI, YAN, additional, and ZHU, DALONG, additional
- Published
- 2018
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16. Maternal and Neonatal Outcomes in Pregnancy Complicated by Type 1 Diabetes Mellitus
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BI, YAN, primary, XU, QIANYUE, additional, LU, JING, additional, HU, JUN, additional, LI, JINGJING, additional, GE, ZHIJUAN, additional, and ZHU, DALONG, additional
- Published
- 2018
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17. Gut Microbiota as a Potential Target for Treatment of Polycystic Ovary Syndrome
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ZHANG, BINGJIE, primary, SHEN, SHANMEI, additional, BI, YAN, additional, and ZHU, DALONG, additional
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- 2018
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18. Effect of Liraglutide, Metformin, and Gliclazide on Body Composition in Type 2 Diabetic Patients with Nonalcoholic Fatty Liver Disease—A Randomised Trial
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FENG, WENHUAN, primary, BI, YAN, additional, LI, PING, additional, YIN, TINGTING, additional, GAO, CAIXIA, additional, SHEN, SHANMEI, additional, GAO, LIJUN, additional, JIANG, CAN, additional, and ZHU, DALONG, additional
- Published
- 2018
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19. Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes
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Zhang, Zhou, primary, Zhang, Bing, additional, Wang, Xin, additional, Zhang, Xin, additional, Yang, Qing X., additional, Qing, Zhao, additional, Lu, Jiaming, additional, Bi, Yan, additional, and Zhu, Dalong, additional
- Published
- 2018
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20. Olfactory Dysfunction Mediates Adiposity in Cognitive Impairment of Type 2 Diabetes: Insights From Clinical and Functional Neuroimaging Studies.
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Zhou Zhang, Bing Zhang, Xin Wang, Xin Zhang, Yang, Qing X., Zhao Qing, Wen Zhang, Dalong Zhu, Yan Bi, Zhang, Zhou, Zhang, Bing, Wang, Xin, Zhang, Xin, Qing, Zhao, Zhang, Wen, Zhu, Dalong, and Bi, Yan
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SMELL ,TYPE 2 diabetes ,GLUCAGON-like peptide 1 ,MONTREAL Cognitive Assessment ,GLYCEMIC control ,OBESITY - Abstract
Objective: Large numbers of people with type 2 diabetes are obese. However, changes in cognition and related brain function in obese people with diabetes have not been characterized. Here, we investigated cognition, olfactory function, and odor-induced brain alterations in these patients and therapeutic effects of glucagon-like peptide 1 receptor agonists (GLP-1Ras) on their psychological behavior and olfactory networks.Research Design and Methods: Cognitive, olfactory, and odor-induced brain activation assessments were administered to 35 obese and 35 nonobese people with type 2 diabetes and 35 control subjects matched for age, sex, and education. Among them, 20 obese individuals with diabetes with inadequate glycemic control and metformin monotherapy received GLP-1Ra treatment for 3 months and were reassessed for metabolic, cognitive, olfactory, and neuroimaging changes.Results: Obese subjects with diabetes demonstrated lower general cognition and olfactory threshold scores, decreased left hippocampal activation, and disrupted seed-based functional connectivity with right insula compared with nonobese subjects with diabetes. Negative associations were found between adiposity and episodic memory and between fasting insulin and processing speed test time in diabetes. Mediation analyses showed that olfactory function and left hippocampus activation mediated these correlations. With 3-month GLP-1Ra treatment, obese subjects with diabetes exhibited improved Montreal Cognitive Assessment (MoCA) score, olfactory test total score, and enhanced odor-induced right parahippocampus activation.Conclusions: Obese subjects with type 2 diabetes showed impaired cognition and dysfunctional olfaction and brain networks, the latter of which mediated adiposity in cognitive impairment of diabetes. GLP-1Ras ameliorated cognitive and olfactory abnormalities in obese subjects with diabetes, providing new perspectives for early diagnosis and therapeutic approaches for cognitive decrements in these patients. [ABSTRACT FROM AUTHOR]- Published
- 2019
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21. Altered Odor-Induced Brain Activity as an Early Manifestation of Cognitive Decline in Patients With Type 2 Diabetes.
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Zhou Zhang, Bing Zhang, Xin Wang, Xin Zhang, Qing X. Yang, Zhao Qing, Jiaming Lu, Yan Bi, Dalong Zhu, Zhang, Zhou, Zhang, Bing, Wang, Xin, Zhang, Xin, Yang, Qing X, Qing, Zhao, Lu, Jiaming, Bi, Yan, and Zhu, Dalong
- Subjects
PEOPLE with diabetes ,COGNITION disorders ,ODORS ,NEURAL circuitry ,OLFACTORY perception ,MAGNETIC resonance imaging ,PSYCHOLOGY ,TYPE 2 diabetes & psychology ,BRAIN ,COMPARATIVE studies ,NEUROPSYCHOLOGICAL tests ,RESEARCH methodology ,MEDICAL cooperation ,NEUROLOGIC examination ,TYPE 2 diabetes ,SENSORY perception ,REGRESSION analysis ,RESEARCH ,EVALUATION research ,CASE-control method ,NEURAL pathways ,EXECUTIVE function - Abstract
Type 2 diabetes is reported to be associated with olfactory dysfunction and cognitive decline. However, whether and how olfactory neural circuit abnormalities involve cognitive impairment in diabetes remains uncovered. This study thus aimed to investigate olfactory network alterations and the associations of odor-induced brain activity with cognitive and metabolic parameters in type 2 diabetes. Participants with normal cognition, including 51 patients with type 2 diabetes and 41 control subjects without diabetes, underwent detailed cognitive assessment, olfactory behavior tests, and odor-induced functional MRI measurements. Olfactory brain regions showing significantly different activation between the two groups were selected for functional connectivity analysis. Compared with the control subjects, patients with diabetes demonstrated significantly lower olfactory threshold score, decreased brain activation, and disrupted functional connectivity in the olfactory network. Positive associations of the disrupted functional connectivity with decreased neuropsychology test scores and reduced pancreatic function were observed in patients with diabetes. Notably, the association between pancreatic function and executive function was mediated by olfactory behavior and olfactory functional connectivity. Our results suggested the alteration of olfactory network is present before clinically measurable cognitive decrements in type 2 diabetes, bridging the gap between the central olfactory system and cognitive decline in diabetes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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22. Latent Autoimmune Diabetes in Adults With Low-Titer GAD Antibodies: Similar Disease Progression With Type 2 Diabetes
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Liu, Lingjiao, primary, Li, Xia, additional, Xiang, Yufei, additional, Huang, Gan, additional, Lin, Jian, additional, Yang, Lin, additional, Zhao, Yunjuan, additional, Yang, Zhifang, additional, Hou, Can, additional, Li, Yijun, additional, Liu, Jie, additional, Zhu, Dalong, additional, Leslie, R. David, additional, Wang, Xiangbing, additional, and Zhou, Zhiguang, additional
- Published
- 2014
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23. Lipid Profiling Reveals Different Therapeutic Effects of Metformin and Glipizide in Patients With Type 2 Diabetes and Coronary Artery Disease
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Zhang, Yifei, primary, Hu, Chunxiu, additional, Hong, Jie, additional, Zeng, Jun, additional, Lai, Shenghan, additional, Lv, Ankang, additional, Su, Qing, additional, Dong, Yan, additional, Zhou, Zhiguang, additional, Tang, Weili, additional, Zhao, Jiajun, additional, Cui, Lianqun, additional, Zou, Dajin, additional, Wang, Dawang, additional, Li, Hong, additional, Liu, Chao, additional, Wu, Guoting, additional, Shen, Jie, additional, Zhu, Dalong, additional, Wang, Weiqing, additional, Shen, Weifeng, additional, Ning, Guang, additional, and Xu, Guowang, additional
- Published
- 2014
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24. Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in New-Onset Type 1 Diabetes: A Multicenter Analysis
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D’Addio, Francesca, primary, Valderrama Vasquez, Alessandro, additional, Ben Nasr, Moufida, additional, Franek, Edward, additional, Zhu, Dalong, additional, Li, Lirong, additional, Ning, Guang, additional, Snarski, Emilian, additional, and Fiorina, Paolo, additional
- Published
- 2014
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25. Latent Autoimmune Diabetes in Adults With Low-Titer GAD Antibodies: Similar Disease Progression With Type 2 Diabetes: A Nationwide, Multicenter Prospective Study (LADA China Study 3)
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Liu, Lingjiao, Li, Xia, Xiang, Yufei, Huang, Gan, Lin, Jian, Yang, Lin, Zhao, Yunjuan, Yang, Zhifang, Hou, Can, Li, Yijun, Liu, Jie, Zhu, Dalong, Leslie, R David, Wang, Xiangbing, Zhou, Zhiguang, and LADA China Study Group
- Abstract
OBJECTIVE: This study investigated the relationship between GAD autoantibody (GADA) titers and changing of [beta]-cell function in patients with latent autoimmune diabetes in adults (LADA). RESEARCH DESIGN AND METHODS: This 3-year prospective study enrolled 95 subjects from 15 Chinese cities including 25 high-titer (GADA >=180 units/mL) LADA patients, 42 low-titer (GADA <180 units/mL) LADA patients, and 28 type 2 diabetic patients, the latter two groups as controls of similar age, sex, and BMI. Clinical characteristics were determined annually, including glycosylated hemoglobin (HbA1c), fasting C-peptide (FCP), and 2-h postprandial C-peptide (PCP). RESULTS: Despite similar initial FCP and PCP, FCP and PCP both decreased more in subjects with high GADA titer (FCP from mean 0.49 nmol/L at entry to 0.13 nmol/L at the third year; P < 0.05) than with low GADA titer (FCP from mean 0.48 to 0.38 nmol/L) and type 2 diabetes (FCP from mean 0.47 to 0.36 nmol/L); the latter two groups being similar. After 3 years, residual [beta]-cell function (FCP >0.2 nmol/L) was detected in only 42% with an initial high GADA titer compared with 90% with a low GADA titer and 97% with type 2 diabetes (P < 0.01 for both). GADA positivity at the third year persisted more in subjects with initially high GADA (92%) than with low GADA (26%) titers (P < 0.01). CONCLUSIONS: In selected LADA patients, initial GADA titers identified subjects with different degrees of persistent autoimmunity and disease progression. LADA patients with a low GADA titer had metabolic phenotypes and loss of [beta]-cell function similar to type 2 diabetic patients. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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26. Autologous nonmyeloablative hematopoietic stem cell transplantation in new-onset type 1 diabetes: a multicenter analysis.
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D'Addio F, Valderrama Vasquez A, Ben Nasr M, Franek E, Zhu D, Li L, Ning G, Snarski E, and Fiorina P
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- Adolescent, Adult, C-Peptide metabolism, Child, Cyclophosphamide therapeutic use, Female, Humans, Immunosuppression Therapy, Insulin therapeutic use, Male, Remission Induction, Transplantation, Autologous, Diabetes Mellitus, Type 1 therapy, Hematopoietic Stem Cell Transplantation adverse effects
- Abstract
Type 1 diabetes (T1D) is one of the major autoimmune diseases affecting children and young adults worldwide. To date, the different immunotherapies tested have achieved insulin independence in <5% of treated individuals. Recently, a novel hematopoietic stem cell (HSC)-based strategy has been tested in individuals with new-onset T1D. The aim of this study was to determine the effects of autologous nonmyeloablative HSC transplantation in 65 individuals with new-onset T1D who were enrolled in two Chinese centers and one Polish center, pooled, and followed up for 48 months. A total of 59% of individuals with T1D achieved insulin independence within the first 6 months after receiving conditioning immunosuppression therapy (with antithymocyte globulin and cyclophosphamide) and a single infusion of autologous HSCs, and 32% remained insulin independent at the last time point of their follow-up. All treated subjects showed a decrease in HbA1c levels and an increase in C-peptide levels compared with pretreatment. Despite a complete immune system recovery (i.e., leukocyte count) after treatment, 52% of treated individuals experienced adverse effects. Our study suggests the following: 1) that remission of T1D is possible by combining HSC transplantation and immunosuppression; 2) that autologous nonmyeloablative HSC transplantation represents an effective treatment for selected individuals with T1D; and 3) that safer HSC-based therapeutic options are required., (© 2014 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.)
- Published
- 2014
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