1. Nonalcoholic Fatty Liver Disease (NAFLD) Outcome Post–Bariatric Surgery in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Consortium
- Author
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FIDA BACHA, RESMI GUPTA, TODD M. JENKINS, MARY BRANDT, THOMAS H. INGE, DAVID KLEINER, STAVRA XANTHAKOS, and TEEN-LABS CONSORTIUM
- Subjects
medicine.medical_specialty ,Sleeve gastrectomy ,Bariatrics ,medicine.diagnostic_test ,business.industry ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,medicine.disease ,Surgery ,Insulin resistance ,Weight loss ,Liver biopsy ,Nonalcoholic fatty liver disease ,Internal Medicine ,medicine ,Observational study ,medicine.symptom ,business ,Dyslipidemia - Abstract
Teen-LABS is a multicenter, prospective observational study of adolescents undergoing bariatric surgery. Predictors of resolution of NAFLD post-surgery are unclear. We evaluated changes in serum ALT levels, an acceptable surrogate when liver biopsy is not feasible, in 219 Teen-LABS subjects 3 years post gastric bypass or vertical sleeve gastrectomy. Three years post-surgery, median BMI declined to 38.4 from 52.6 kg/m2 at baseline (p In conclusion, while weight loss was associated with decreased ALT by 6 months post-surgery, improved fasting glycemia, insulin resistance and dyslipidemia indices were also independently associated with ALT decline. Association between change in predictor variables and decline in ALT from baseline to 6 months.Change in predictor variables over 6 monthsEstimate (SE) adjusted for age, race, sexp-valueEstimate (SE) adjusted for age, race, sex, change in BMIp-valueDecline in BMI0.64 (0.13) Disclosure F. Bacha: Research Support; Self; AstraZeneca, JAEB Center For Health Research, National Institutes of Health, Pediatric Diabetes Consortium. R. Gupta: None. T.M. Jenkins: None. M. Brandt: None. T.H. Inge: Consultant; Self; Standard Bariatrics, Independent Medical Expert Consulting Services, UpToDate. D. Kleiner: None. S. Xanthakos: None.
- Published
- 2018
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