1. Pharmacokinetics of insulin aspart in pregnant women with type 1 diabetes: every day is different
- Author
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Roman Hovorka, Robert J. B. Goudie, D.P. Lunn, Helen R. Murphy, Goudie, Robert [0000-0001-9554-1499], Hovorka, Roman [0000-0003-2901-461X], and Apollo - University of Cambridge Repository
- Subjects
medicine.medical_specialty ,Evening ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Insulin, Isophane ,Pregnancy in Diabetics ,Insulin aspart ,Pregnancy ,Internal medicine ,Diabetes mellitus ,Internal Medicine ,Medicine ,Humans ,Insulin ,Original Research ,Advanced and Specialized Nursing ,Type 1 diabetes ,Meal ,business.industry ,digestive, oral, and skin physiology ,Clinical Care/Education/Nutrition/Psychosocial Research ,medicine.disease ,Hypoglycemia ,Pregnancy Complications ,Postprandial ,Endocrinology ,Diabetes Mellitus, Type 1 ,Female ,Preconception Care ,business ,medicine.drug - Abstract
OBJECTIVE A recent randomized trial compared prandial insulin aspart (IAsp) with human insulin in type 1 diabetic pregnancy. The aim of this exploratory analysis was to investigate the incidence of severe hypoglycemia during pregnancy and compare women enrolled preconception with women enrolled during early pregnancy. RESEARCH DESIGN AND METHODS IAsp administered immediately before each meal was compared with human insulin administered 30 min before each meal in 99 subjects (44 to IAsp and 55 to human insulin) randomly assigned preconception and in 223 subjects (113 for IAsp and 110 for human insulin) randomly assigned in early pregnancy (
- Published
- 2014