1. Haptoglobin Polymorphism Predicts 30-Day Mortality and Heart Failure in Patients With Diabetes and Acute Myocardial Infarction
- Author
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Michael Kapeliovich, Shimon A. Reisner, Michael Shochat, Doron Aronson, Haim Hammerman, Rabea Asleh, Rachel Lotan, Abeer Sulieman, Walter Markiewicz, Mahmoud Suleiman, Simcha R. Meisel, Ariel Roguin, Nina S. Levy, and Andrew P. Levy
- Subjects
medicine.medical_specialty ,Time Factors ,Genotype ,Heart disease ,Endocrinology, Diabetes and Metabolism ,Myocardial Infarction ,Logistic regression ,Polymorphism (computer science) ,Internal medicine ,Diabetes mellitus ,Diabetes Mellitus ,Odds Ratio ,Internal Medicine ,medicine ,Clinical endpoint ,Humans ,Prospective Studies ,Myocardial infarction ,Polymorphism, Genetic ,Haptoglobins ,biology ,business.industry ,Haptoglobin ,medicine.disease ,Logistic Models ,Phenotype ,Heart failure ,Multivariate Analysis ,Cardiology ,biology.protein ,business - Abstract
Patients with diabetes presenting with acute myocardial infarction (AMI) have an increased rate of death and heart failure. Patients with diabetes homozygous for the haptoglobin (Hp) 1 allele (Hp 1-1) develop fewer vascular complications. We tested the hypothesis that Hp type is related to the outcome of patients with diabetes presenting with AMI. We prospectively assessed the relationship between Hp type and 30-day mortality and heart failure in 1,437 patients with AMI (506 with diabetes). Multivariate logistic regression identified a significant interaction between Hp type and diabetes status on these outcome measures. Hp type was not related to outcome among patients without diabetes. In contrast, Hp 1-1 was associated with a strong protective effect with regard to the primary end point of death (OR 0.14, P 0.015) and for death and heart failure (OR 0.35; 95% CI 0.15‐0.86, P 0.018) among patients with diabetes. Finally, among patients with diabetes, Hp 1-1 was associated with smaller infarct size. This study demonstrates that in patients with diabetes and AMI, the Hp type is an important determinant of clinical outcome and infarct size. Diabetes 54:2802‐2806, 2005
- Published
- 2005
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